Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression

Guo-lin Wu; Li Zhang; Tian-yi Li; Jiu Chen; Guo-you Yu; Jian-ping Li

doi:10.1007/s11655-010-0109-9

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Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression

OriginalPaper | Updated：2021-08-27

- Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression
- Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression
- 中国结合医学杂志（英文版） 2010年16卷第2期页码：109-113
- Affiliations：
  
  1. The First Affiliated Hospital, College of Medicine, Zhejiang University,Hangzhou,China
  2. Center for Drug Reevaluation, State Food and Drug Administration,Beijing,China
  3. Zhejiang Chinese Medical University,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-010-0109-9
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-5-16，
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Wu, Gl., Zhang, L., Li, Ty. et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression., Chin. J. Integr. Med. 16, 109–113 (2010). https://doi.org/10.1007/s11655-010-0109-9

Guo-lin Wu, Li Zhang, Tian-yi Li, et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression[J]. Chinese Journal of Integrative Medicine, 2010,16(2):109-113.
Wu, Gl., Zhang, L., Li, Ty. et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression., Chin. J. Integr. Med. 16, 109–113 (2010). https://doi.org/10.1007/s11655-010-0109-9 DOI：

Guo-lin Wu, Li Zhang, Tian-yi Li, et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression[J]. Chinese Journal of Integrative Medicine, 2010,16(2):109-113. DOI： 10.1007/s11655-010-0109-9.

摘要

To observe the clinical combination effect of Jinlong Capsule (金龙胶囊

JLC) and transcatheter arterial chemoembolization (TACE) on the patients with primary hepatic carcinoma (PHC) and JLC’ s influence on serum osteopontin (OPN) expression and elucidate the correlation between the serum OPN level and curative effect of JLC and TACE. A total of 98 patients with PHC were observed in a randomized controlled trial (RCT). They were assigned to the Chinese medicine (CM) group (53 patients who were treated with TACE and JLC) and the intervention group (45 patients who were treated with TACE only). The serum OPN levels were measured before and after treatment by quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Forty healthy people were assigned to the control group. The clinical efficacy was observed and Karnofsky score (KPS) was graded. The clinical efficacy of the CM group (60.38%) was better than that of the intervention group (40.00 %)

and the KPS (84.35±12.19) was higher than the intervention group (69.86± 11.58) (P<0.05). The serum OPN levels before and after treatment in the patients with PHC were significantly elevated compared with those in the control group (P<0.01). After treatment

the OPN levels in CM group (117.69 <±78.50) were significantly lower compared with those in intervention group (151.09±83.90

P<0.05). The OPN levels of responders were remarkably lowered than the non-responders after treatment

and the level of OPN in the CM group was lower than the intervention group (P<0.05). The short-term clinical efficacy and the quality of life of patients with PHC can be improved by combining JLC with TACE. The serum OPN levels in PHC patients can reflect the curative effect of treatment and the prognosis of the disease.

Abstract

To observe the clinical combination effect of Jinlong Capsule (金龙胶囊

the OPN levels in CM group (117.69 <±78.50) were significantly lower compared with those in intervention group (151.09±83.90

P<0.05). The OPN levels of responders were remarkably lowered than the non-responders after treatment

关键词

Jinlong Capsuletranscatheter arterial chemoembolizationprimary hepatic carcinomaosteopontinclinical efficacy

Keywords

Jinlong Capsuletranscatheter arterial chemoembolizationprimary hepatic carcinomaosteopontinclinical efficacy

references

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Su XK, Zhou WS, Xu FB, Wang FJ, Zhao TQ, Lin YS, et al. The clinical observation of combination treatment of traditional Chinese medcine and TACE of primary hepatic carcinoma in 219 patients. J Tradit Chin Med (Chin) 2004; 45:434–436.

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Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003;9:416–423.

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