Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence

Chun Gong; Shao-lie Huang; Jian-feng Huang; Zhi-fang Zhang; Ming Luo; Yu Zhao; Xiao-jie Jiang

doi:10.1007/s11655-010-0114-z

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Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence

OriginalPaper | Updated：2021-08-27

- Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence
- Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence
- 中国结合医学杂志（英文版） 2010年16卷第2期页码：114-118
- Affiliations：
  
  1. The Cardiovascular Department, the First Affiliated Hospital of Nanchang University,Nanchang,China
  2. The Ultrasonic Department, the First Affiliated Hospital of Nanchang University,Nanchang,China
  3. Fengcheng Municipal Hospital of Traditional Chinese Medicine, Fengcheng,China
  4. The Dynamic ECG Department, the First Affiliated Hospital of Nanchang University,Nanchang,China
  5. The Cardiovascular Department, the Fourth Affiliated Hospital of Nanchang University,Nanchang,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-010-0114-z
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-5-16，
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Gong, C., Huang, Sl., Huang, Jf. et al. Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence., Chin. J. Integr. Med. 16, 114–118 (2010). https://doi.org/10.1007/s11655-010-0114-z

Chun Gong, Shao-lie Huang, Jian-feng Huang, et al. Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence[J]. Chinese Journal of Integrative Medicine, 2010,16(2):114-118.
Gong, C., Huang, Sl., Huang, Jf. et al. Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence., Chin. J. Integr. Med. 16, 114–118 (2010). https://doi.org/10.1007/s11655-010-0114-z DOI：

Chun Gong, Shao-lie Huang, Jian-feng Huang, et al. Effects of combined therapy of Xuezhikang Capsule (血脂康胶囊) and Valsartan on hypertensive left ventricular hypertrophy and heart rate turbulence[J]. Chinese Journal of Integrative Medicine, 2010,16(2):114-118. DOI： 10.1007/s11655-010-0114-z.

摘要

To observe the effect of combined therapy with Xuezhikang Capsule (血脂康胶囊

XZK) and Valsartan on left ventricular hypertrophy (LVH) and heart rate turbulence (HRT) in hypertensive patients. Ninety primary hypertensive patients with LVH were randomly assigned to three groups. Basic treatment

including aspirin

β-blockers

calcium antagonists

etc. were administered to all patients. Additionally

Valsartan (VS

80 mg once a day) was given to the 30 patients in the VS group. Valsartan (in the same dosage) and XZK (600 mg

twice a day) were given to the 32 patients in the Chinese medicine (CM) group

while none was given to the 28 patients in the control group. The therapeutic course lasted for 24 months. Changes in left ventricular mass index (LVMI) measured by cardiac ultrasonic indices

HRT parameters

including the original heart rate (TO) and slope coeffificient (TS)

systolic and diastolic blood pressures (SBP and DBP)

as well as blood cholesterol level (TC) were measured before and after treatment. After treatment

TO and LVMI were lowered

while TS increased in both the VS group and the CM group (P<0.01)

but changed insignificantly in the control group. Significant differences between the CM group and the control group were shown in terms of TO

LVMI

SBP

DBP and TS (P<0.01); and between the CM group and the VS group in terms of TO

LVMI and TS (P<0.01). Moreover

HRT parameters showed an evident correlation with LVMI (r=0.519–0.635

P<0.01). Combined therapy with XZK and Valsartan can improve hypertensive LVH and HRT parameters

and lessen the damage on the autonomous nervous system.

Abstract

To observe the effect of combined therapy with Xuezhikang Capsule (血脂康胶囊

including aspirin

β-blockers

calcium antagonists

etc. were administered to all patients. Additionally

Valsartan (VS

80 mg once a day) was given to the 30 patients in the VS group. Valsartan (in the same dosage) and XZK (600 mg

twice a day) were given to the 32 patients in the Chinese medicine (CM) group

while none was given to the 28 patients in the control group. The therapeutic course lasted for 24 months. Changes in left ventricular mass index (LVMI) measured by cardiac ultrasonic indices

HRT parameters

including the original heart rate (TO) and slope coeffificient (TS)

systolic and diastolic blood pressures (SBP and DBP)

as well as blood cholesterol level (TC) were measured before and after treatment. After treatment

TO and LVMI were lowered

while TS increased in both the VS group and the CM group (P<0.01)

but changed insignificantly in the control group. Significant differences between the CM group and the control group were shown in terms of TO

LVMI

SBP

DBP and TS (P<0.01); and between the CM group and the VS group in terms of TO

LVMI and TS (P<0.01). Moreover

HRT parameters showed an evident correlation with LVMI (r=0.519–0.635

P<0.01). Combined therapy with XZK and Valsartan can improve hypertensive LVH and HRT parameters

and lessen the damage on the autonomous nervous system.

关键词

heart rate turbulenceLeft Ventricular HypertrophyhypertensionXuezhikang capsuleValsartan

Keywords

heart rate turbulenceLeft Ventricular HypertrophyhypertensionXuezhikang capsuleValsartan

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Kawasaki T, Azuma A, Asada S, Hadase M, Kamitani T, Kawasaki S, et al. Heart rate turbulence and clinical prognosis in hypertrophic cardiomyopathy and myocardial infarction. Circ J 2003;677:601.

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