Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats

Xiao-dong Wang; Tian-xiang Gu; En-yi Shi; Chun-mao Lu; Chun Wang

doi:10.1007/s11655-010-0162-4

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Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats

OriginalPaper | Updated：2021-08-27

- Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats
- Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats
- 中国结合医学杂志（英文版） 2010年16卷第2期页码：162-166
- Affiliations：
  
  Department of Cardiac Surgery, the First Affiliated Hospital, China Medical University,Shenyang,China
- Author bio：
- Funds：
  
  Supported by the Research Project of Education Department of Liaoning Province (No. 2004C050) in 2005 and Project of Technology Department of Liaoning Province (No. 2006401013-2) in 2006.
- DOI：10.1007/s11655-010-0162-4
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-5-16，
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Wang, Xd., Gu, Tx., Shi, Ey. et al. Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats., Chin. J. Integr. Med. 16, 162–166 (2010). https://doi.org/10.1007/s11655-010-0162-4

Xiao-dong Wang, Tian-xiang Gu, En-yi Shi, et al. Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats[J]. Chinese Journal of Integrative Medicine, 2010,16(2):162-166.
Wang, Xd., Gu, Tx., Shi, Ey. et al. Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats., Chin. J. Integr. Med. 16, 162–166 (2010). https://doi.org/10.1007/s11655-010-0162-4 DOI：

Xiao-dong Wang, Tian-xiang Gu, En-yi Shi, et al. Effect and mechanism of panaxoside Rg1 on neovascularization in myocardial infarction rats[J]. Chinese Journal of Integrative Medicine, 2010,16(2):162-166. DOI： 10.1007/s11655-010-0162-4.

摘要

To investigate the effects and mechanisms of panaxoside Rg1 on the new vessel formation in acute myocardial infarction (AMI) rats. The AMI model of male Sprague-Dawley (SD) rats was established

and rats were randomly divided into the AMI model group

the treatment group of panaxoside Rg1

the placebo group and the treatment group of panaxoside Rg1 plus rapamycin. Cardiac creatases were determined with 1 mL blood drawn from vena caudalis of the rats 48 h after the model was successfully made. After 4 weeks

Evans blue was injected into the aorta roots of the rats

and then

red tetrazoline was dyed again and the myocardial infarction area was evaluated. The microvessel density (MVD) of infarction area was determined by the immunohistochemistry of CD31; enzyme-linked immunosorbent assay (ELISA) was used to detect the protein content of CD31 and hypoxia inducible factor-1α (HIF-1α) of the infarction area. The MVD in the infarction area and the contents of CD31 and HIF-1α in the Rg1 treatment group were higher than those in the AMI model group significantly (P<0.05). The cardiac creatase and infarction area were lower in the Rg1 treatment group than those in the AMI model group significantly (P<0.05). The above effects

however

disappeared when rapamycin

the antagonist of mammalian target of rapamycin (mTOR)

was administered simultaneously. Panaxoside Rg1 could increase the expression of HIF-1α and CD31 of myocardium and stimulate the angiogenesis. The above mentioned role of panaxoside Rg1 might be related to the excitation of mTOR receptor.

Abstract

To investigate the effects and mechanisms of panaxoside Rg1 on the new vessel formation in acute myocardial infarction (AMI) rats. The AMI model of male Sprague-Dawley (SD) rats was established

and rats were randomly divided into the AMI model group

the treatment group of panaxoside Rg1

Evans blue was injected into the aorta roots of the rats

and then

however

disappeared when rapamycin

the antagonist of mammalian target of rapamycin (mTOR)

关键词

ginsenoside Rg1mTOR proteincollateral circulationsignal transductionmyocardial infarction

Keywords

ginsenoside Rg1mTOR proteincollateral circulationsignal transductionmyocardial infarction

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