Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection

Zhi-hong Lu; Xiao-guang Bai; Li-ze Xiong; Yong-hui Wang; Yi Wang; Qiang Wang

doi:10.1007/s11655-010-0229-6

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Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection

OriginalPaper | Updated：2021-08-27

- Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection
- Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection
- 中国结合医学杂志（英文版） 2010年16卷第3期页码：229-233
- Affiliations：
  
  Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University,Xi’an,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No.30600840, 30725039, 30772074);Innovative Foundation of Xijing Hospital (No. XJCX05M23)
- DOI：10.1007/s11655-010-0229-6
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-8-8，
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Lu, Zh., Bai, Xg., Xiong, Lz. et al. Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection., Chin. J. Integr. Med. 16, 229–233 (2010). https://doi.org/10.1007/s11655-010-0229-6

Zhi-hong Lu, Xiao-guang Bai, Li-ze Xiong, et al. Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection[J]. Chinese Journal of Integrative Medicine, 2010,16(3):229-233.
Lu, Zh., Bai, Xg., Xiong, Lz. et al. Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection., Chin. J. Integr. Med. 16, 229–233 (2010). https://doi.org/10.1007/s11655-010-0229-6 DOI：

Zhi-hong Lu, Xiao-guang Bai, Li-ze Xiong, et al. Effect of electroacupuncture preconditioning on serum S100β and NSE in patients undergoing craniocerebral tumor resection[J]. Chinese Journal of Integrative Medicine, 2010,16(3):229-233. DOI： 10.1007/s11655-010-0229-6.

摘要

To investigate the effect of electroacupuncture preconditioning on the serum level of S100 calcium-binding protein beta (S100β) and neuron-specific enolase (NSE) in patients undergoing craniocerebral tumor operation. A total of 32 patients

who would go through craniocerebral tumor resection under general anesthesia

were randomly assigned to two groups

16 in each group. Patients in the electroacupuncture (EA) group received electroacupuncture on Fengfu acupoint (Du16) and Fengchi acupoint (GB20) for 30 min

2 h before operation. The stimulus is 1–4 mA with a density wave frequency of 2/15 Hz. Patients in the control group received no pretreatment. Anesthesia was maintained with remifentanil at the dose of 4–8 mg/kg per hour

pumped intravenous drip of vecuronium at 1.0–2.0 μg/kg each hour

and discontinuous intravenous dripped with vecuronium bromide at 0.5–1 mg. The serum levels of S100β and NSE were measured with ELISA before operation

before skin incision

after tumor removal

at the end of operation

and at 24 h after operation. The serum level of S100β and NSE did not change before skin incision. The serum level of NSE increased significantly and the level of S100β increased insignificantly after the tumor resection. The serum levels of S100β and NSE in the EA group and the control group were 1.16±0.28 μg/L vs 1.47± 0.33 μg/L

24.7±13.3 μg/L vs 31.4±14.1 μg/L at the end of the operation

respectively. Twenty-four h after operation

the correspondence indices were 1.18±0.31 μg/L vs 1.55±0.26 μg/L

and 25.5±12.4 μg/L vs 32.4± 11.7 μg/L. The two indices at these two time points were significantly increased than those before operation

respectively (P<0.05). At the end of the operation and 24 h post-operation

the serum levels of S100β and NSE in the EA group were significantly lower than those in the control group (P<0.05). Electroacupuncture Fengchi and Fengfu for 30 min before craniocerbral tumor operation could decrease the serum level of S100β and NSE

thus may have potential protective effect on brain damage

which needs to befurther studied.

Abstract

who would go through craniocerebral tumor resection under general anesthesia

were randomly assigned to two groups

16 in each group. Patients in the electroacupuncture (EA) group received electroacupuncture on Fengfu acupoint (Du16) and Fengchi acupoint (GB20) for 30 min

pumped intravenous drip of vecuronium at 1.0–2.0 μg/kg each hour

and discontinuous intravenous dripped with vecuronium bromide at 0.5–1 mg. The serum levels of S100β and NSE were measured with ELISA before operation

before skin incision

after tumor removal

at the end of operation

24.7±13.3 μg/L vs 31.4±14.1 μg/L at the end of the operation

respectively. Twenty-four h after operation

the correspondence indices were 1.18±0.31 μg/L vs 1.55±0.26 μg/L

and 25.5±12.4 μg/L vs 32.4± 11.7 μg/L. The two indices at these two time points were significantly increased than those before operation

respectively (P<0.05). At the end of the operation and 24 h post-operation

thus may have potential protective effect on brain damage

which needs to befurther studied.

关键词

electroacupuncturepreconditioningS100 calcium-binding protein betaneuron-specific enolasecraniotomy

Keywords

electroacupuncturepreconditioningS100 calcium-binding protein betaneuron-specific enolasecraniotomy

references

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Lu ZH, Xiong LZ, Tian L, Liu XL, Liu YH, Chen SY. Pretreatment with repeated electroacupuncture increases HSP70 expression after cerebral ischemic injury in rats. Chin J Anesth (Chin) 2004;24:453–456.

Wang Y, Yang J. Effect of acupuncturing Fengchi and Fengfu on blood supply of the brain in post stroke patients. Clin J Chin Tradit Med (Chin) 2005;17:251–253.

Li XR, Huang LL. Clinical use of Zhang Zhongjing’s acupuncture method. Fujian J Chin Trad Med (Chin) 1998;29:47.

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