Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine

Jian-wen Long; Yu-ying Wang; Xian-ming Pi; Ya-ting Tu

doi:10.1007/s11655-010-0504-2

Your Location：

Home >

Browse articles >

Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine

OriginalPaper | Updated：2021-08-27

- Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine
- Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine
- 中国结合医学杂志（英文版） 2010年16卷第4期页码：353-356
- Affiliations：
  
  1. Union Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan,China
  2. Affiliated Hospital of Hubei University of Traditional Chinese Medicine,Wuhan,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-010-0504-2
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-8-10，
Scan for full text
Long, Jw., Wang, Yy., Pi, Xm. et al. Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine., Chin. J. Integr. Med. 16, 353–356 (2010). https://doi.org/10.1007/s11655-010-0504-2

Jian-wen Long, Yu-ying Wang, Xian-ming Pi, et al. Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine[J]. Chinese Journal of Integrative Medicine, 2010,16(4):353-356.
Long, Jw., Wang, Yy., Pi, Xm. et al. Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine., Chin. J. Integr. Med. 16, 353–356 (2010). https://doi.org/10.1007/s11655-010-0504-2 DOI：

Jian-wen Long, Yu-ying Wang, Xian-ming Pi, et al. Clinical observation on the treatment of chronic urticaria with total glucosides of paeony capsule combined with citirizine[J]. Chinese Journal of Integrative Medicine, 2010,16(4):353-356. DOI： 10.1007/s11655-010-0504-2.

摘要

To assess the effect and adverse reaction of total glucosides of paeony capsule (TGPC) in combining with citirizine for the treatment of chronic urticaria. A total of 120 patients were assigned to two groups by lottery

65 in the treated group and 55 in the control group. They all were orally treated with citirizine tablet 10 mg per day

but to the treated group

additional 0.2 g TGPC was given three times per day

the therapeutic course for both groups was 4 weeks. The effectiveness of treatment was observed

and the changes of total symptom score

serum levels of interleukin-4 (IL-4)

and immunoglobulin E (IgE) were measured before and after treatment. Moreover

a follow-up was carried out one month after ending the treatment. The dropped cases were two in the treated group and seven in the control group; so

the study was accomplished on 63 patients in the treated group and 48 patients in the control group. The total effective rate was assessed at 73.02% (46/63) in the treated group

which was significantly higher than 47.92% (23/48) in the control group (P<0.01). After treatment

the total symptom score decreased in both groups

but the decrement in the treated group was more significant (P<0.05). Serum levels of IL-4 and IgE in the treated group lowered significantly

while the changes in the control group were insignificant

so statistical significant differences were shown between groups (P<0.01). A follow-up study showed that the relapse rate in the treated group was 30.00% (6/20)

while that in the control group was 90.00% (9/10)

and the former was lower than the latter (P<0.01). Adverse reactions

revealed as drowsiness

dizziness

and weakness

were seen in eight cases and seven cases in the two groups

respectively. Besides

mild diarrhea occurred in two cases of the treated group. The treatment of TGPC combining citirizine shows definite curative effect in treating chronic urticaria

with low relapse rate and without evident adverse reaction. Its therapeutic effect might be realized by means of regulating patients’ immune function. Besides

the medication should be continued for a rather long period to achieve the full effect.

Abstract

65 in the treated group and 55 in the control group. They all were orally treated with citirizine tablet 10 mg per day

but to the treated group

additional 0.2 g TGPC was given three times per day

the therapeutic course for both groups was 4 weeks. The effectiveness of treatment was observed

and the changes of total symptom score

serum levels of interleukin-4 (IL-4)

and immunoglobulin E (IgE) were measured before and after treatment. Moreover

a follow-up was carried out one month after ending the treatment. The dropped cases were two in the treated group and seven in the control group; so

the study was accomplished on 63 patients in the treated group and 48 patients in the control group. The total effective rate was assessed at 73.02% (46/63) in the treated group

which was significantly higher than 47.92% (23/48) in the control group (P<0.01). After treatment

the total symptom score decreased in both groups

but the decrement in the treated group was more significant (P<0.05). Serum levels of IL-4 and IgE in the treated group lowered significantly

while the changes in the control group were insignificant

so statistical significant differences were shown between groups (P<0.01). A follow-up study showed that the relapse rate in the treated group was 30.00% (6/20)

while that in the control group was 90.00% (9/10)

and the former was lower than the latter (P<0.01). Adverse reactions

revealed as drowsiness

dizziness

and weakness

were seen in eight cases and seven cases in the two groups

respectively. Besides

mild diarrhea occurred in two cases of the treated group. The treatment of TGPC combining citirizine shows definite curative effect in treating chronic urticaria

with low relapse rate and without evident adverse reaction. Its therapeutic effect might be realized by means of regulating patients’ immune function. Besides

the medication should be continued for a rather long period to achieve the full effect.

关键词

total glucosides of paeony capsulecitirizinecombined therapychronic urticaria observation

Keywords

total glucosides of paeony capsulecitirizinecombined therapychronic urticaria observation

references

Zhang XJ, ed. Dermatology. 6th ed. Beijing: People’s Medical Publishing House; 2004: 108.

The Clinical Cooperation Group, Yu BE, Liao KH. Therapeutic effect of mizolastine in the treatment of 6 970 patients with chronic urticaria. Chin J Dermatol (Chin) 2003;36:340–341.

Tang SS, Zheng XY, Sun GZ. Analysis of allergen specific IgE and specific IgG in patients with chronic urticaria. Exp Lab Med (Chin) 2009;27:121–122.

Yang YG. Detection of allergen and serum IgE antibodies in 192 cases of chronic urticaria. Modern Diag Treat (Chin) 2009;20:248.

Zheng WJ, Lin YK, Yan LL, Liang L. Clinical research on serum cytokines in patients with chronic urticaria. Chin J Clin Lab Sci (Chin) 2004;4:294.

Sun WL, Bi ZG. The level of serum IL-4 and IFN-γ in patients with autoimmune chronic urticaria. Acta Univ Med Nanjing (Chin) 2003;23:548–549.

Burns T, ed. Rook’s textbook of dermatology. 7th ed. Oxford: Blackwell Publishing; 2004:2318.

Wang B, Chen MZ, Xu SY. Effect of total glucosides of paeony (TGP) on tumor necrosis factor produced by peritoneal macrophages in rats. Chin Pharmacol Bull 1995;11:38.

Wang B, Yao YY, Zhou AW. Study on immunomodulatory effect of total glucosides of paeony and its relationship with nitric oxide in adjuvant arthritis rats. Chin J Immunol (Chin) 1996;12:104.

Wang Y, Xing HY. Clinical observation on effect of total glucosides of paeony combined with methotrexate on rheumatoid arthritis. Chin J Integr Tradit West Med (Chin) 2007;27:839–840.

Wang SL, Wang JP, Bian H, Wang H, Li P. Clinical observation on total glucosides of paeony combined with sulfasalazine in treatment of ankylosing spondylitis. Chin J Integr Tradit West Med (Chin) 2007;27:217–219.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

Clinical observation on the treatment of male neoplastic anemia with Yixuesheng capsule (益血生胶囊) combined with recombination human erythropoietin

Clinical observation on 30 cases of chronic renal failure treated with Shentekang Capsule and peritoneal dialysisand peritoneal dialysis