Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage

Hui Liao; Jie Xu; Zhan-zeng Lin; Jia-yue Yang; Qiang Chen

doi:10.1007/s11655-010-0514-0

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Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage

OriginalPaper | Updated：2021-08-27

- Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage
- Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage
- 中国结合医学杂志（英文版） 2010年16卷第4期页码：304-308
- Affiliations：
  
  Department of Integrative Chinese and Western Medicine, the Forth Central Hospital of Tianjin City,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the Special Fund for Integrative Chinese and Western Medical Researches of Tianjin City (No. 07057)
- DOI：10.1007/s11655-010-0514-0
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-8-10，
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Liao, H., Xu, J., Lin, Zz. et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage., Chin. J. Integr. Med. 16, 304–308 (2010). https://doi.org/10.1007/s11655-010-0514-0

Hui Liao, Jie Xu, Zhan-zeng Lin, et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage[J]. Chinese Journal of Integrative Medicine, 2010,16(4):304-308.
Liao, H., Xu, J., Lin, Zz. et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage., Chin. J. Integr. Med. 16, 304–308 (2010). https://doi.org/10.1007/s11655-010-0514-0 DOI：

Hui Liao, Jie Xu, Zhan-zeng Lin, et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage[J]. Chinese Journal of Integrative Medicine, 2010,16(4):304-308. DOI： 10.1007/s11655-010-0514-0.

摘要

To study the effect and mechanism of Tianhuang Granule (田黄冲剂

THG) on: hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring

serum matrix metalloproteinase-9 (MMP-9) level observation

and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function de ficit). Sixty patients with ACH were equally randomized: into two groups by lottery

the control group and the THG group; all were treated with conventional therapy

but to the patients in the THG group

THG was given orally in addition for 28 days. Changes of ICP

MMP-9 expression

and NIHSS scores

as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients

were estimated and compared. (1) ICP was lowered more significantly in the: THG group

showing a significant difference between groups on day 7 (P<0.05). (2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group. (3) The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3 (P<0.05)

but in the control group

the day of significant reduction was delayed to day 14

and the degrees on day 7 and day 14 in the two groups were significantly different (P<0.05 and P<0.01). (4) NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28 (P<0.05 and P<0.01). THG can effectively lower ICP

down-regulate MMP-9 expression

promote the absorption: of cerebral hematoma and hydrocephalus

and improve the nerve function

showing a clinical effectiveness than conventional therapy.

Abstract

To study the effect and mechanism of Tianhuang Granule (田黄冲剂

THG) on: hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring

serum matrix metalloproteinase-9 (MMP-9) level observation

and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function de ficit). Sixty patients with ACH were equally randomized: into two groups by lottery

the control group and the THG group; all were treated with conventional therapy

but to the patients in the THG group

THG was given orally in addition for 28 days. Changes of ICP

MMP-9 expression

and NIHSS scores

as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients

were estimated and compared. (1) ICP was lowered more significantly in the: THG group

but in the control group

the day of significant reduction was delayed to day 14

down-regulate MMP-9 expression

promote the absorption: of cerebral hematoma and hydrocephalus

and improve the nerve function

showing a clinical effectiveness than conventional therapy.

关键词

acute cerebral hemorrhageintracranial pressurematrix metalloproteinase-9hydrocephalusChinese medicinal therapyTianhuang Granule

Keywords

acute cerebral hemorrhageintracranial pressurematrix metalloproteinase-9hydrocephalusChinese medicinal therapyTianhuang Granule

references

Wang WZ, ed. Neurology. 4th ed. Beijing: People’s Medical Publishing House;2004:149.

Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, et al. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke 2006;37:1399.

Young FB, Weir CJ, Lees KR. Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials. Stroke 2005;36:2187–2192.

Liao H, Li DP, Xu J, Chen Q, Yi L. Clinical observation on treatment of acute hemorrhagic stroke by Tianhuang Huoxue Tongluo Decoction. Chin J Integr Tradit West Med (Chin) 2004;24:698–700.

Tang W, Zou SF. Effect of acupuncture precondition on cerebral edema and adenosine in rats with cerebral ischemia/reperfusion. Chin J Integr Tradit West Med Intensive Crit Care (Chin) 2007;14:166–168.

Su CY, Chen HM, Kwan AL, Lin YH, Guo NW. Neuropsychological impairment after hemorrhagic stroke in basal ganglia. Arch Clin Neuropsychol 2007;22:465–474.

Nys GM, van Zandvoort MJ, de Kort PL, Jansen BP, de Haan EH, Kappelle LJ. Cognitive disorders in acute stroke: prevalence and clinical determinants. Cerebrovasc Dis 2007;23:408–416.

Fujita K, Kato T, Shibayama K, Imada H, Yamauchi M, Yoshimoto N, et al. Protective effect against 17 beta-estradiol on neuronal apoptosis in hippocampus tissue following transient ischemia/recirculation in Mongolian gerbils via down-regulation of tissue transglutaminase activity. Neurochem Res 2006;31:1059–1068.

Luo AC, Chen AY, Hung VK, Yaw LP, Fung MK, Ho MC, et al. Endothelin-1 overexpression leads to further water accumulation and brain edema after middie cerebral artery occlusion via aquaporin 4 expression in astreytic end-feet. J Cereb Blood Flow Metab 2005;25:998–1011.

Yang JW, Quan DH, Zhang QC, Guo CZ. Pathological mechanism of cerebral hemorrhage. J Brain Nerv Dis (Chin) 2005;13:470–471.

Gao XM, ed. Chinese meteria medica. Beijing: People’s Medical Publishing House;2000:595–605, 988–1017, 1104–1118, 1422.

Luo HS, Wang JH, eds. Pharmacology of traditional Chinese medicine and clinical research. Guangzhou: South China University Technology Press;1991:210, 248.

Tang LM. Rhubarb’s basis of modern medicine and applied research. Chin J Integr Tradit West Med Intensive Crit Care (Chin) 2001;8:185.

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