Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats

Yong-hua Zhao; You-hua Xu; Ying Guan; Ping Xiang

doi:10.1007/s11655-010-0524-y

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Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats

OriginalPaper | Updated：2021-08-27

- Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats
- Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats
- 中国结合医学杂志（英文版） 2010年16卷第4期页码：344-347
- Affiliations：
  
  Faculty of Chinese Medicine, Macau University of Science and Technology, Macao,China
- Author bio：
- Funds：
  
  Supported by Science and Technology Development Fund of Macao Special Administrative Region (No.105/2005/A)
- DOI：10.1007/s11655-010-0524-y
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-8-10，
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Zhao, Yh., Xu, Yh., Guan, Y. et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats., Chin. J. Integr. Med. 16, 344–347 (2010). https://doi.org/10.1007/s11655-010-0524-y

Yong-hua Zhao, You-hua Xu, Ying Guan, et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats[J]. Chinese Journal of Integrative Medicine, 2010,16(4):344-347.
Zhao, Yh., Xu, Yh., Guan, Y. et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats., Chin. J. Integr. Med. 16, 344–347 (2010). https://doi.org/10.1007/s11655-010-0524-y DOI：

Yong-hua Zhao, You-hua Xu, Ying Guan, et al. Effects of Yinian Jiangya Decoction (颐年降压饮) containing serum on cytokines secretion of vascular endothelium of spontaneously hypertensive rats[J]. Chinese Journal of Integrative Medicine, 2010,16(4):344-347. DOI： 10.1007/s11655-010-0524-y.

摘要

To observe the effects of Yinian Jiangya Decoction (颐年降压饮

YNJYD) on cytokine secretion in spontaneoulsy hypertensive rats (SHRs) vascular endothelium. Aortic endothelial cells (ECs) were primarily cultured from SHRs; male SD rats were treated with different doses (high

medium

and low doses) of YNJYD

the blood was collected on the 21st day

and then

the serum was separated. ECs were cocultured with the serum for different time courses

and the culture supernatant concentrations of endothelin (ET)-1

nitric oxide (NO)

tissue-type plasminogen activator (t-PA)

and plasminogen activator inhibitor (PAI-1) were determined by ABC-ELISA methods. ET-1

t-PA

and PAI-1 levels in endothelial cell culture supernatant were increased in a time-dependent manner; YNJYD could significantly elevate NO and t-PA expressions in ECs

while ET-1 and PAI-1 expressions were dramatically decreased; these effects of YNJYD were in a concentration-dependent manner. The therapeutic effect of YNJYD on hypertension is attributed to its effect on regulating vessel dilation and blood coagulation

in which ET-1/NO and PAI-1/t-PA are two pairs of pivotal mediators.

Abstract

To observe the effects of Yinian Jiangya Decoction (颐年降压饮

medium

and low doses) of YNJYD

the blood was collected on the 21st day

and then

the serum was separated. ECs were cocultured with the serum for different time courses

and the culture supernatant concentrations of endothelin (ET)-1

nitric oxide (NO)

tissue-type plasminogen activator (t-PA)

and plasminogen activator inhibitor (PAI-1) were determined by ABC-ELISA methods. ET-1

t-PA

and PAI-1 levels in endothelial cell culture supernatant were increased in a time-dependent manner; YNJYD could significantly elevate NO and t-PA expressions in ECs

in which ET-1/NO and PAI-1/t-PA are two pairs of pivotal mediators.

关键词

Yinian Jiangya Decoctionendothelial cellcytokine

Keywords

Yinian Jiangya Decoctionendothelial cellcytokine

references

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Zhang YH, Hu Y, Mei H, Wang HF, Guo T, Wei WN. Compared study for three methods to isolate endothelial cells from rat aorta. Chin J Microcirc (Chin) 2007;17:15–16.

Hynynen MM, Khalil RA. The vascular endothelin system in hypertension—recent patents and discoveries. Recent Pat Cardiovasc Drug Discov 2006;1:95–108.

Spieker LE, Noll G, Ruschitzka FT, Lüscher TF. Endothelin receptor antagonists in congestive heart failure: a new therapeutic principle for the future? J Am Coll Cardiol 2001;37:1493–505.

Giles TD. Aspects of nitric oxide in health and disease: a focus on hypertension and cardiovascular disease. J Clin Hypertens (Greenwich) 2006;8:2–16.

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Tabak O, Gelisgen R, Uzun H, Kalender B, Balci H, Curgunlu A, et al. Hypertension and hemostatic/fibrinolytic balance disorders. Clin Invest Med 2009;32:E285.

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Ulfhammer E, Ridderstrale W, Andersson M, Karlsson L, Hrafnkelsdóttir T, Jern S. Prolonged cyclic strain impairs the fibrinolytic system in cultured vascular endothelial cells. J Hypertens 2005;23:1551–1557.

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