Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana

Victor Kuete; Marlise D. J. Dongfack; Armelle T. Mbaveng; Marie-Christine Lallemand; Hanh T. Van-Dufat; Jean-Duplex Wansi; Elisabeth Seguin; François Tillequin; Jean Wandji

doi:10.1007/s11655-010-0527-8

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Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana

OriginalPaper | Updated：2021-08-27

- Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
- Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana
- 中国结合医学杂志（英文版） 2010年16卷第4期页码：337-343
- Affiliations：
  
  1. Department of Biochemistry, Faculty of Science, University of Dschang, Dschang,Cameroon
  2. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I., Yaoundé,Cameroon
  3. Laboratoire de Pharmacognosie de l’Université Paris Descartes, UMR/CNRS No 8638, Faculté des Sciences Biologiques et Pharmaceutiques,Paris,France
  4. Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé,Cameroon
  5. Department of Chemistry, University of Douala, Faculty of Science, Douala,Cameroon
  6. Laboratoire de Pharmacognosie, UFR de Médecine Pharmacie Rouen, Rouen Cedex 1,France
- Author bio：
- Funds：
  
  Supported by International Foundation for Science (No. IFS/2624-3F).
- DOI：10.1007/s11655-010-0527-8
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-8-10，
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Kuete, V., Dongfack, M.D.J., Mbaveng, A.T. et al. Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana, ., Chin. J. Integr. Med. 16, 337–343 (2010). https://doi.org/10.1007/s11655-010-0527-8

Victor Kuete, Marlise D. J. Dongfack, Armelle T. Mbaveng, et al. Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana[J]. Chinese Journal of Integrative Medicine, 2010,16(4):337-343.
Kuete, V., Dongfack, M.D.J., Mbaveng, A.T. et al. Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana, ., Chin. J. Integr. Med. 16, 337–343 (2010). https://doi.org/10.1007/s11655-010-0527-8 DOI：

Victor Kuete, Marlise D. J. Dongfack, Armelle T. Mbaveng, et al. Antimicrobial activity of the methanolic extract and compounds from the stem bark of Drypetes tessmanniana[J]. Chinese Journal of Integrative Medicine, 2010,16(4):337-343. DOI： 10.1007/s11655-010-0527-8.

摘要

To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana

fractions (DTB1-5) as well as compounds [friedelin (2)

7-dioxofriedelane (3)

15-dioxofriedelane (4)

3β- O-(E)-3

5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6)

and 3β

6α-dihydroxylup-20(29)-ene (7). Agar disc diffusion was used to determine the sensitivity of the above samples

whilst the microdilution method was used for the determination of the minimal inhibitory concentration (MIC) and the minimal microbicidal concentrations (MMC). The diffusion test showed that the crude extract was able to prevent the growth of all tested organisms. All other samples showed selective activity. The inhibitory effect of the fraction DTB2 was noted on 63.7%

that of DTB1 and DBT3 on 54.6%

whilst DTB4 and DTB5 were active on 9.1% of the 11 tested organisms. The tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4

36.7% for compound 6

and 18.2% for compound 7. The results of the MIC determinations indicated perceptible values for DTB and compound 4 on 81.8% of the tested organisms. For other samples

MICs were detected on 0–63.7%. The lowest MIC value (78.12 μg/mL) for the crude extract and fractions (DTB2) was observed on M. audouinii. The corresponding value for isolated compounds (156.25 μg/mL) was noted with compounds 3 on S. faecalis and 4 on M. audouinii audouinii. The results of the MMC determination suggested that the microbicidal effect of most of the tested samples on the studied microorganisms could be expected. The methanol extract from the stem bark of Drypetes. tessmanniana (Euphorbiaceae) as well as some of the isolated compounds might be potential sources of new antimicrobial drugs.

Abstract

To evaluate the antimicrobial activity of the methanol extract from the stem bark of Drypetes tessmanniana

fractions (DTB1-5) as well as compounds [friedelin (2)

7-dioxofriedelane (3)

15-dioxofriedelane (4)

3β- O-(E)-3

5-dihydroxycinnamoyl-11-oxo-olean-12-ene (6)

and 3β

6α-dihydroxylup-20(29)-ene (7). Agar disc diffusion was used to determine the sensitivity of the above samples

that of DTB1 and DBT3 on 54.6%

whilst DTB4 and DTB5 were active on 9.1% of the 11 tested organisms. The tested compounds prevented the growth of 81.8% of the tested microbial species for compounds 3 and 4

36.7% for compound 6

and 18.2% for compound 7. The results of the MIC determinations indicated perceptible values for DTB and compound 4 on 81.8% of the tested organisms. For other samples

关键词

Drypetes tessmannianaEuphorbiaceaecompoundsantimicrobial activity

Keywords

Drypetes tessmannianaEuphorbiaceaecompoundsantimicrobial activity

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