Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine

Wan-yin Wu; Xiao-bing Yang; Hong Deng; Shun-qin Long; Liang-sheng Sun; Wen-feng He; Yu-shu Zhou; Gui-ya Liao; Sai-man Chan; Shi-pu Shan

doi:10.1007/s11655-010-0535-8

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Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine

OriginalPaper | Updated：2021-08-27

- Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine
- Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine
- 中国结合医学杂志（英文版） 2010年16卷第5期页码：406-410
- Affiliations：
  
  Department of Cancer, Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by Canadian Terry Fox Run Foundation for Cancer Research
- DOI：10.1007/s11655-010-0535-8
  中图分类号：
- 纸质出版日期：2010，
  
  网络出版日期：2010-9-25，
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Wu, Wy., Yang, Xb., Deng, H. et al. Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine., Chin. J. Integr. Med. 16, 406–410 (2010). https://doi.org/10.1007/s11655-010-0535-8

Wan-yin Wu, Xiao-bing Yang, Hong Deng, et al. Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine[J]. Chinese Journal of Integrative Medicine, 2010,16(5):406-410.
Wu, Wy., Yang, Xb., Deng, H. et al. Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine., Chin. J. Integr. Med. 16, 406–410 (2010). https://doi.org/10.1007/s11655-010-0535-8 DOI：

Wan-yin Wu, Xiao-bing Yang, Hong Deng, et al. Treatment of advanced non-small cell lung cancer with extracorporeal high frequency thermotherapy combined with Chinese medicine[J]. Chinese Journal of Integrative Medicine, 2010,16(5):406-410. DOI： 10.1007/s11655-010-0535-8.

摘要

To observe the clinical efficacy and benefit response of extracorporeal high frequency thermotherapy (EHFT) combined with Chinese medicine (CM) in the treatment of patients with advanced nonsmall cell lung cancer. The study adopted a prospective

small sample and randomized controlled method

and the advanced non-small cell lung cancer patients were assigned to two groups according to the table of random digits

one having the treatment of EHFT combined with CM (the treatment group)

the other only with CM (the control group). The patients in the treatment group were treated with EHFT one hour once per day

together with CM differentiation decoction

250 mL orally taken

twice daily for 14 days as one cycle

and 3–4 cycles was performed. The patients in the control group were treated only with CM differentiation decoction using the same dose as the treatment group. The efficacies were evaluated after three to four cycles of treatment. Primary endpoints were disease control rate (DCR) and time to progression (TTP). Secondary endpoints were overall survival time and 1-year survival rate. Sixty-six patients accomplished the study. After the patients underwent different treatments

none of the patients got a complete response or partial response in both groups. In the treatment group

DCR was 72.2%

and 10 had progression of disease (28.8%)

while the DCR of the control group was 63.3%

and 11 had progression of disease (36.7%); there was a significant statistical difference (P <0.05)

suggesting that the combined regimen had superiority on the DCR. As for long-term efficacy

the median survival time (MST) of the treatment group was 7.5 months

TTP was 5.5 months

and 1-year survival rate was 21.4 %; in the control group

the results were 6.8 months

4.5 months and 16.6% respectively. There was significant statistical difference on TTP (P <0.05)

but no difference on MST or 1-year survival rate. EHFT combined with CM differentiation has better tolerance and short-term efficacy in the treatment of patients with advanced NSCLC.

Abstract

small sample and randomized controlled method

and the advanced non-small cell lung cancer patients were assigned to two groups according to the table of random digits

one having the treatment of EHFT combined with CM (the treatment group)

the other only with CM (the control group). The patients in the treatment group were treated with EHFT one hour once per day

together with CM differentiation decoction

250 mL orally taken

twice daily for 14 days as one cycle

none of the patients got a complete response or partial response in both groups. In the treatment group

DCR was 72.2%

and 10 had progression of disease (28.8%)

while the DCR of the control group was 63.3%

and 11 had progression of disease (36.7%); there was a significant statistical difference (P <0.05)

suggesting that the combined regimen had superiority on the DCR. As for long-term efficacy

the median survival time (MST) of the treatment group was 7.5 months

TTP was 5.5 months

and 1-year survival rate was 21.4 %; in the control group

the results were 6.8 months

4.5 months and 16.6% respectively. There was significant statistical difference on TTP (P <0.05)

but no difference on MST or 1-year survival rate. EHFT combined with CM differentiation has better tolerance and short-term efficacy in the treatment of patients with advanced NSCLC.

关键词

non-small cell lung cancerextracorporeal high frequency thermotherapyChinese medicine differentiationefficacy

Keywords

non-small cell lung cancerextracorporeal high frequency thermotherapyChinese medicine differentiationefficacy

references

Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med 2002;346:92–98.

Parkin DM, Bray F, Ferlay J, Pisani P. Estimating the world cancer burden: Globocan 2000. Int J Cancer 2001;94:153–156.

Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. Lancet 2009;361:947–957.

Chen ZM, Xu GW, Ren LG, Wang LB. Experimental research on combination of thermotherapy and chemotherapy for treating Hep-A-22 in mice. J Pract Oncol 2001;15:4–5.

Murthy R, Honavar S G, Naik M, Reddy V A. Thermochemotherapy in hereditary retinoblastoma. Br J Ophthalmol 2003;87:90–95.

Bhowmick S, Swanlund DJ, Coad JE, Lulloff L, Hoey MF, Bischof JC. Evaluation of thermal in a prostate cancer model using a wet electrode radiofrequency probe. J Endourol 2001;15:629–640.

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