Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease

Ming-hui Yang; Hai-ming Wang; Yi Liu

doi:10.1007/s11655-011-0618-1

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Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease

OriginalPaper | Updated：2021-08-27

- Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease
- Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease
- 中国结合医学杂志（英文版） 2011年17卷第1期页码：43-47
- Affiliations：
  
  Institute of Traditional Chinese Medicine, General Hospital of PLA,Beijing,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No. 30672762)
- DOI：10.1007/s11655-011-0618-1
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-1-22，
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Yang, Mh., Wang, Hm. & Liu, Y. Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease., Chin. J. Integr. Med. 17, 43–47 (2011). https://doi.org/10.1007/s11655-011-0618-1

Ming-hui Yang, Hai-ming Wang, Yi Liu. Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease[J]. Chinese Journal of Integrative Medicine, 2011,17(1):43-47.
Yang, Mh., Wang, Hm. & Liu, Y. Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease., Chin. J. Integr. Med. 17, 43–47 (2011). https://doi.org/10.1007/s11655-011-0618-1 DOI：

Ming-hui Yang, Hai-ming Wang, Yi Liu. Effect of Bushen Huoxue Decoction (补肾活血饮) on the orphan receptor and tyrosine hydroxylase in the brain of rats with Parkinson’s disease[J]. Chinese Journal of Integrative Medicine, 2011,17(1):43-47. DOI： 10.1007/s11655-011-0618-1.

摘要

To explore the effect of Bushen Huoxue Decoction (补肾活血饮

BHD) on the orphan receptor (Nurr1) and tyrosine hydroxylase (TH) in the brain of rats with Parkinson’s disease (PD). One hundred and twenty SD rats were divided into 100 in the model group and 20 in the normal control group

fififtyeight SD rats from the model group

established into PD model successfully by injuring their substantia nigra (SSN) with 6-hydroxydopamine

were divided equally into the model group and the test group

and they were treated with saline and BHD

respectively

for eight successive weeks. The change in the rats’ behavior before and after treatment was observed by counting the cycles of rotation induced by apomorphine injection; the pathology of neurons

level of Nurr1 mRNA expression

and amount of TH positive cells in SSN were observed after treatment. The rats’ behavior was improved in the tested group signifificantly

the rotation cycle after treatment being 84.0±20.0 cycles/40 min

which was signifificantly lower than that in the model group (377.0 ±62.3 cycles/40 min

P<0.01). Besides

the Nurr1 mRNA expression and TH positive cell in the test group were 0.97±0.15 and 49.40±14.72

respectively

which were signifificantly higher than those in the model group

0.22±0.03 and 5.45±2.58

respectively (all P<0.01). BHD could treat PD by enhancing the Nurr1 mRNA expression

increasing the TH content in brain

and promoting the repairing of injured neuron in cerebral SSN.

Abstract

To explore the effect of Bushen Huoxue Decoction (补肾活血饮

fififtyeight SD rats from the model group

established into PD model successfully by injuring their substantia nigra (SSN) with 6-hydroxydopamine

were divided equally into the model group and the test group

and they were treated with saline and BHD

respectively

for eight successive weeks. The change in the rats’ behavior before and after treatment was observed by counting the cycles of rotation induced by apomorphine injection; the pathology of neurons

level of Nurr1 mRNA expression

and amount of TH positive cells in SSN were observed after treatment. The rats’ behavior was improved in the tested group signifificantly

the rotation cycle after treatment being 84.0±20.0 cycles/40 min

which was signifificantly lower than that in the model group (377.0 ±62.3 cycles/40 min

P<0.01). Besides

the Nurr1 mRNA expression and TH positive cell in the test group were 0.97±0.15 and 49.40±14.72

respectively

which were signifificantly higher than those in the model group

0.22±0.03 and 5.45±2.58

respectively (all P<0.01). BHD could treat PD by enhancing the Nurr1 mRNA expression

increasing the TH content in brain

and promoting the repairing of injured neuron in cerebral SSN.

关键词

Parkinson’s diseaseBushen Huoxue DecoctionChinese MedicineOrphan receptorTyrosine Hydroxylase

Keywords

Parkinson’s diseaseBushen Huoxue DecoctionChinese MedicineOrphan receptorTyrosine Hydroxylase

references

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Xu R, Li G, Yao YQ. Apomorphine caused morphological changes in ventral tagmental area and abnormal rotations in rats with Parkinson disease induced by 6-hydroxydopamine. Acta Univ Med Anhui (Chin) 2006;41:247–249.

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Saijo K, Winner B, Carson CT, Collier JG, Leah B, Rosenfeld MG, et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009;137:47–59.

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