Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats

Jing Cai; Teng Zheng; Lei Zhang; Yun Tian; Min-he Yang; Jian Du

doi:10.1007/s11655-011-0636-z

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Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats

OriginalPaper | Updated：2021-08-27

- Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats
- Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats
- 中国结合医学杂志（英文版） 2011年17卷第10期页码：758-763
- Affiliations：
  
  1. Fujian Institute of Integrative Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. Fujian Entry-Exit Inspection and Quarantine Bureau of P. R. China,Fuzhou,China
  3. Fujian Normal University,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30672729), CHEN Ke-ji Development Fund of Integrative Medicine (No. CKJ2010025)
- DOI：10.1007/s11655-011-0636-z
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2013-3-26，
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Cai, J., Zheng, T., Zhang, L. et al. Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats., Chin. J. Integr. Med. 17, 758–763 (2011). https://doi.org/10.1007/s11655-011-0636-z

Jing Cai, Teng Zheng, Lei Zhang, et al. Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats[J]. Chinese Journal of Integrative Medicine, 2011,17(10):758-763.
Cai, J., Zheng, T., Zhang, L. et al. Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats., Chin. J. Integr. Med. 17, 758–763 (2011). https://doi.org/10.1007/s11655-011-0636-z DOI：

Jing Cai, Teng Zheng, Lei Zhang, et al. Effects of Herba Epimedii and Fructus Ligustri lucidi on the transcription factors in hypothalamus of aged rats[J]. Chinese Journal of Integrative Medicine, 2011,17(10):758-763. DOI： 10.1007/s11655-011-0636-z.

摘要

To comparatively analyze the difference in the expression of 54 transcription factors in the hypothalamus using protein chips following the medication of Chinese drugs for Shen (肾)-tonification

Herba Epimedii

and Fructus Ligustri lucidi (FL) to aged rats. Wistar rats

aged 15 months of SPF grade

were randomized into three groups

three males and three females in each group. They were medicated with Herba Epimedii decoction (HED

0.14 g/kg)

Fructus Ligustri lucidi decoction (FLD

0.12 g/kg)

and distilled water

respectively

twice a day for 15 days. The rats were sacrificed at the morning of the 16th day 1 h after medication

and their hypothalamus was taken and made into homogenate under an ice-bath for detecting the expression of transcription factors with chip technique. The expressions of signal transduction and transcription activation factor-6 (Stat-6) and androgen receptor (AR) were up-regulated

and those of pre-B transcription factor1 (Pbx-1)

stat-1 and AP-2 were down-regulated in both HED and FLD treated groups

but these changes occurred mainly in female rats in the former while mainly in males in the latter. Chinese drugs for Shen-tonification could impact the expression of transcription factors in the hypothalamus of aged rats

dominantly on the neuro-endocrine factors responsible for the growth and development. The effects of drugs for tonifying Shen-yang and for tonifying Shen-yin are different

which is probably one of the pharmacological mechanisms of the Shen-tonifying drugs.

Abstract

To comparatively analyze the difference in the expression of 54 transcription factors in the hypothalamus using protein chips following the medication of Chinese drugs for Shen (肾)-tonification

Herba Epimedii

and Fructus Ligustri lucidi (FL) to aged rats. Wistar rats

aged 15 months of SPF grade

were randomized into three groups

three males and three females in each group. They were medicated with Herba Epimedii decoction (HED

0.14 g/kg)

Fructus Ligustri lucidi decoction (FLD

0.12 g/kg)

and distilled water

respectively

twice a day for 15 days. The rats were sacrificed at the morning of the 16th day 1 h after medication

and those of pre-B transcription factor1 (Pbx-1)

stat-1 and AP-2 were down-regulated in both HED and FLD treated groups

dominantly on the neuro-endocrine factors responsible for the growth and development. The effects of drugs for tonifying Shen-yang and for tonifying Shen-yin are different

which is probably one of the pharmacological mechanisms of the Shen-tonifying drugs.

关键词

Herba EpimediiFructus Ligustri luciditranscription factoraged rathypothalamus

Keywords

Herba EpimediiFructus Ligustri luciditranscription factoraged rathypothalamus

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