Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats

Li Xiong; Jun-jian Zhang; Dong Sun; Hui Liu

doi:10.1007/s11655-011-0643-0

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Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats

OriginalPaper | Updated：2021-08-27

- Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats
- Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats
- 中国结合医学杂志（英文版） 2011年17卷第2期页码：134-140
- Affiliations：
  
  Department of Neurology, Zhongnan Hospital of Wuhan University,Wuhan,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0643-0
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-3-9，
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Xiong, L., Zhang, Jj., Sun, D. et al. Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats., Chin. J. Integr. Med. 17, 134–140 (2011). https://doi.org/10.1007/s11655-011-0643-0

Li Xiong, Jun-jian Zhang, Dong Sun, et al. Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats[J]. Chinese Journal of Integrative Medicine, 2011,17(2):134-140.
Xiong, L., Zhang, Jj., Sun, D. et al. Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats., Chin. J. Integr. Med. 17, 134–140 (2011). https://doi.org/10.1007/s11655-011-0643-0 DOI：

Li Xiong, Jun-jian Zhang, Dong Sun, et al. Therapeutic benefit of Yangxue Qingnao Granule (养血清脑颗粒) on cognitive impairment induced by chronic cerebral hypoperfusion in rats[J]. Chinese Journal of Integrative Medicine, 2011,17(2):134-140. DOI： 10.1007/s11655-011-0643-0.

摘要

To observe the therapeutic effect of Yangxue Qingnao Granule (养血清脑颗粒

YXQNG) on cognitive impairment induced by chronic cerebral hypoperfusion and to investigate its impact on oxidative stress

apoptosis

and the cholinergic system. Adult male Wistar rats were subjected to chronic cerebral hypoperfusion by permanent occlusion of bilateral common carotid arteries (2-VO). Thirty rats were randomly assigned to one of the five treatment groups in a 1:1:1:1:1 ratio: sham operation plus normal saline treatment

2-VO plus normal saline treatment

2-VO plus YXQNG at a dose of 2 g·kg−1·d−1 or 4 g·kg−1·d−1

or 2-VO plus rivastigmine 2 mg·kg−1·d−1. The Morris water maze test was used to assess the spatial memory retrieval. Apoptosis

total antioxide capacity (T-AOC)

acetylcholine esterase (AchE) and choline acetyl transferase (ChAT) activities in the hippocampus and the cortex were investigated. In the chronic cerebral hypoperfusion model

the 2-VO plus saline treatment resulted in impaired special learning as shown by the significantly prolonged escape latency and shorter swim time in the first quadrant as compared to the sham operation. The impairment was associated with apoptosis and significant decreases in T-AOC

AchE and ChAT activities in the hippocampus and the cortex. Treatment with YXQNG at either 2 g·kg−1·d−1 or 4 g·kg−1·d−1 dose

or rivastigmine resulted in significantly shorter escape latencies and longer swim time in the first quadrant. YXQNG at both doses

but not rivastigmine

had significant reduction in apoptosis

and significant increases in T-AOC and ChAT activity in both the hippocampus and the cortex. Unlike rivastigmine

neither dose of YXQNG showed significant reduction in AchE activity. YXQNG ameliorated cognitive impairment induced by chronic cerebral hypoperfusion. The protective effect may be mediated through its regulation of apoptosis and activities of T-AOC and ChAT in the hippocampus and cortex of the rats in the chronic cerebral hypoperfusion model

a mechanism that is different from rivastigmine.

Abstract

To observe the therapeutic effect of Yangxue Qingnao Granule (养血清脑颗粒

YXQNG) on cognitive impairment induced by chronic cerebral hypoperfusion and to investigate its impact on oxidative stress

apoptosis

2-VO plus normal saline treatment

2-VO plus YXQNG at a dose of 2 g·kg−1·d−1 or 4 g·kg−1·d−1

or 2-VO plus rivastigmine 2 mg·kg−1·d−1. The Morris water maze test was used to assess the spatial memory retrieval. Apoptosis

total antioxide capacity (T-AOC)

acetylcholine esterase (AchE) and choline acetyl transferase (ChAT) activities in the hippocampus and the cortex were investigated. In the chronic cerebral hypoperfusion model

AchE and ChAT activities in the hippocampus and the cortex. Treatment with YXQNG at either 2 g·kg−1·d−1 or 4 g·kg−1·d−1 dose

or rivastigmine resulted in significantly shorter escape latencies and longer swim time in the first quadrant. YXQNG at both doses

but not rivastigmine

had significant reduction in apoptosis

and significant increases in T-AOC and ChAT activity in both the hippocampus and the cortex. Unlike rivastigmine

a mechanism that is different from rivastigmine.

关键词

Yangxue Qingnao granulechronic cerebral hypoperfusionapoptosistotal antioxide capacityacetylcholine esterasecholine acetyl transferase

Keywords

Yangxue Qingnao granulechronic cerebral hypoperfusionapoptosistotal antioxide capacityacetylcholine esterasecholine acetyl transferase

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