Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)

Pei-xun Liu; Jing Gao; Yu-jie Chen; Wei Long; Xiu Shen; Wei-sheng Tang

doi:10.1007/s11655-011-0644-z

Your Location：

Home >

Browse articles >

Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)

OriginalPaper | Updated：2021-08-27

- Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)
- Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)
- 中国结合医学杂志（英文版） 2011年17卷第6期页码：459-463
- Affiliations：
  
  Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine,Tianjin,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0644-z
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-6-10，
Scan for full text
Liu, Px., Gao, J., Chen, Yj. et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)., Chin. J. Integr. Med. 17, 459–463 (2011). https://doi.org/10.1007/s11655-011-0644-z

Pei-xun Liu, Jing Gao, Yu-jie Chen, et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)[J]. Chinese Journal of Integrative Medicine, 2011,17(6):459-463.
Liu, Px., Gao, J., Chen, Yj. et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)., Chin. J. Integr. Med. 17, 459–463 (2011). https://doi.org/10.1007/s11655-011-0644-z DOI：

Pei-xun Liu, Jing Gao, Yu-jie Chen, et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)[J]. Chinese Journal of Integrative Medicine, 2011,17(6):459-463. DOI： 10.1007/s11655-011-0644-z.

摘要

To investigate the anticancer activity of the total flavonoids isolated from a herbal formula

Xianhe Yanling Recipe (仙鹤延龄方)

a recipe commonly used in cancer patients in China. The in vitro anticancer activity of the total flavonoids was determined using the 3-(4

5-dimethylthiazole-2-yl)-2

5-diphenyltetrazolium bromide (MTT) assay on three cancer cell lines: MCF-7 (a human breast adenocarcinoma cell line)

HepG-2 (a human hepatocellular carcinoma cell line) and ES-2 (a human ovarian cancer cell line). The in vivo anticancer effect of the total flavonoids was assessed in a mouse tumor model bearing H22-induced hepatocellular carcinoma

and cisplatin was used as a positive control. The total flavonoids exerted a powerful inhibitory effect on the three cell lines

with 50% inhibiting concentrations (IC50) of 24.948

31.569 and 6.923 μg/mL

respectively. In vivo studies showed that the total flavonoids had dose-dependent inhibitory effects on hepatocellular carcinoma in mice. The total flavonoids from Xianhe Yanling Recipe have potential anticancer activity

and further researches and development are warranted.

Abstract

To investigate the anticancer activity of the total flavonoids isolated from a herbal formula

Xianhe Yanling Recipe (仙鹤延龄方)

a recipe commonly used in cancer patients in China. The in vitro anticancer activity of the total flavonoids was determined using the 3-(4

5-dimethylthiazole-2-yl)-2

5-diphenyltetrazolium bromide (MTT) assay on three cancer cell lines: MCF-7 (a human breast adenocarcinoma cell line)

and cisplatin was used as a positive control. The total flavonoids exerted a powerful inhibitory effect on the three cell lines

with 50% inhibiting concentrations (IC50) of 24.948

31.569 and 6.923 μg/mL

and further researches and development are warranted.

关键词

anticancerflavonoidsXianhe Yanling Recipe3-(45-dimethylthiazole-2-yl)-25-diphenyltetrazolium bromide assayin vivo

Keywords

anticancerflavonoidsXianhe Yanling Recipe3-(45-dimethylthiazole-2-yl)-25-diphenyltetrazolium bromide assayin vivo

references

Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M. Comparative Risk Assessment Collaborating Group (Cancers). Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 2005;366:1784–1793.

Frankenfeld CL, Cerhan JR, Cozen W, Davis S, Schenk M, Morton LM, et al. Dietary flavonoid intake and non-Hodgkin lymphoma risk. Am J Clin Nutr 2008;87:1439–1445.

Cutler DJ, Nettleton JA, Ross JA, Harnack LJ, Jacobs DR Jr, Scrafford CG, et al. Dietary flavonoid intake and risk of cancer in postmenopausal women: the Lowa Women’s Health Study. Int J Cancer 2008;123:664–671.

Pierini R, Gee JM, Belshaw NJ, Johnson IT. Flavonoids and intestinal cancers. Br J Nutrit 2008;99:53–59.

Chang HL, Su JH, Yeh YT, Lee YC, Chen HM, Wu YC, et al. Protoapigenone, a novel flavonoid, inhibits ovarian cancer cell growth in vitro and in vivo. Cancer Lett 2008;267:85–95.

Kim YH, Lee DH, Jeong JH, Guo ZS, Lee YJ. Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochemical Pharmacol 2008;75:1946–1958.

Lee JC, Won SJ, Chao CL, Wu FL, Liu HS, Ling P, et al. Morusin induces apoptosis and suppresses NF-kB activity in human colorectal cancer HT-29 cells. Biochem Biophys Res Commun 2008;372:236–242.

Thors L, Belghiti M, Fowler CJ. Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids. Br J Pharmacol 2008;155:244–252.

Xu X, Qi X, Wang W, Chen G. Separation and determination of flavonoids in Agrimonia pilosa Ledeb. by capillary electrophoresis with electrochemical detection. J Sep Sci 2005;28:647–652.

Zhang H, Chen Y, Huang R. Study on flavonoids from Hedyotis diffusa Wild. J Chin Med Mater (Chin) 2005;28:385–387.

Lu CM, Yang JJ, Wang PY, Lin CC. A new acylated flavonol glycoside and antioxidant effects of Hedyotis diffusa. Planta Med 2000;66:374–377.

Zhen HX, Li P, Zhang H, Qi W, Chen Y, Sun LX. Determination of content of total flavonoids in Solanum lyratum Thunb. Chin Arch Tradit Chin Med (Chin) 2008;26:2231–2233.

Liu XF, Xiang YH, Zhang BG, Zhang WQ. Study on extraction process of glycyrrhiza flavonoids. J Anhui Agric Sci (Chin) 2009;37:2542–2543.

Hale AJ, Smith CA, Sutherland LC, Stoneman VE, Longthorne V, Culhane AC, et al. Apoptosis: molecular regulation of cell death. Eur J Biochem 1996;236:1–26.

Adams JM. Ways of dying: multiple pathways to apoptosis. Gene Dev 2003;17:2481–2495.

Xiao PG, ed. Newly compiled Chinese meteria medica. Beijing: Chemistry Industry Press; 2002:555–561.

Fang XK, Gao J, Zhu DN. Kaempferol and quercetin isolated from Euonymus alatus improve glucose uptake of 3T3-L1 cells without adipogenesis activity. Life Sci 2008;82:615–622.

Zhang Y, Chen AY, Li M, Chen C, Yao Q. Ginkgo Biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res 2008;148:17–23.

Harris DM, Besselink E, Henning SM, Go VL, Heber D. Phytoestrogens induce differential estrogen receptor α- or β-mediated responses in transfected breast cancer cells. Exp Biol Med 2005;230:558–568.

FULL TEXT LINK

More>

浏览量

789

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

In vivo and in vitro antiviral effects of berberine on influenza virus

Wenxia Changfu Formula (温下肠腑方) induces apoptosis of lung adenocarcinoma in a transplanted tumor model of drug-resistance nude mice

A Review on Pharmacological and Analytical Aspects of Naringenin

Effects of Banxia Xiexin Decoction (半夏泻心汤) on Cisplatin-Induced Apoptosis of Human A549 Lung Cancer Cells