Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B

Wen-juan Liu; Yong-hua Zhang; Hai-yin Jiang

doi:10.1007/s11655-011-0708-0

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Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B

OriginalPaper | Updated：2021-08-27

- Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B
- Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B
- 中国结合医学杂志（英文版） 2011年17卷第4期页码：302-306
- Affiliations：
  
  1. Zhejiang Chinese Medical University,Hangzhou,China
  2. The Seventh People’s Hospital of Hangzhou City,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0708-0
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-4-21，
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Liu, Wj., Zhang, Yh. & Jiang, Hy. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B., Chin. J. Integr. Med. 17, 302 (2011). https://doi.org/10.1007/s11655-011-0708-0

Wen-juan Liu, Yong-hua Zhang, Hai-yin Jiang. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B[J]. Chinese Journal of Integrative Medicine, 2011,17(4):302-306.
Liu, Wj., Zhang, Yh. & Jiang, Hy. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B., Chin. J. Integr. Med. 17, 302 (2011). https://doi.org/10.1007/s11655-011-0708-0 DOI：

Wen-juan Liu, Yong-hua Zhang, Hai-yin Jiang. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B[J]. Chinese Journal of Integrative Medicine, 2011,17(4):302-306. DOI： 10.1007/s11655-011-0708-0.

摘要

To analyze the relationship of anxiety state with CD4+ level and CD4+/CD8+ ratio and to observe the effect of Chinese medicine (CM) treatment on anxiety in chronic hepatitis B (CHB) patients. The anxiety state of 120 CHB patients was evaluated based on Hamilton Anxiety Scale (HAMA) scoring. According to the scores

63 patients with scores ≥14 were classified to anxiety and 57 patients with scores <14 to non-anxiety. The differences in CD4+ cells and CD4+/CD8+ ratio between patients with anxiety and non-anxiety were analyzed. Moreover

63 patients with anxiety were randomized into two groups: 31 in the control group were treated with lamivudine (100 mg per day) alone and 32 in the observation group were given equal dosage lamivudine combined with CM treatment depending on syndrome differentiation

all for 12 weeks. The effects of treatment on anxiety state and T-lymphocyte subsets as well as its impact on some CHB-related indices were observed and compared. The anxiety state of CHB patients was negatively correlated with CD4+ and CD4+/CD8+; the level of CD4+ in patients with anxiety was significantly lower than that in non-anxiety patients (P<0.01 or P<0.05). After treatment

anxiety state in the observation group was significantly improved

with their HAMA scores significantly lowered (P<0.01)

and the levels of CD4+ and CD4+/CD8+ were significantly higher than those in the control group (P<0.05 or P<0.01). Moreover

the alanine transaminase recovery rate and the HBV-DNA-negative conversion rate in the observation group were significantly higher than those in the control group

respectively (P<0.05). The anxiety state of CHB patients was related to CD4+ and CD4+/CD8+ levels. CM treatment could improve the anxiety state and showed certain regulatory effect on the patients’ immune system.

Abstract

anxiety state in the observation group was significantly improved

with their HAMA scores significantly lowered (P<0.01)

and the levels of CD4+ and CD4+/CD8+ were significantly higher than those in the control group (P<0.05 or P<0.01). Moreover

the alanine transaminase recovery rate and the HBV-DNA-negative conversion rate in the observation group were significantly higher than those in the control group

关键词

chronic hepatitis Banxiety stateimmuneChinese Medicine

Keywords

chronic hepatitis Banxiety stateimmuneChinese Medicine

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