Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction

Shu Lu; Ke-ji Chen; Qing-you Yang; Hui-ru Sun

doi:10.1007/s11655-011-0756-5

Your Location：

Home >

Browse articles >

Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction

ReviewPaper | Updated：2021-08-27

- Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction
- Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction
- 中国结合医学杂志（英文版） 2011年17卷第6期页码：473-477
- Affiliations：
  
  1. Department of Cardiovascular Diseases, Wuxi Municipal Hospital of Traditional Chinese Medicien, Wuxi City,Jiangsu Province,China
  2. Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0756-5
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-6-10，
Scan for full text
Lu, S., Chen, Kj., Yang, Qy. et al. Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction., Chin. J. Integr. Med. 17, 473–477 (2011). https://doi.org/10.1007/s11655-011-0756-5

Shu Lu, Ke-ji Chen, Qing-you Yang, et al. Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction[J]. Chinese Journal of Integrative Medicine, 2011,17(6):473-477.
Lu, S., Chen, Kj., Yang, Qy. et al. Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction., Chin. J. Integr. Med. 17, 473–477 (2011). https://doi.org/10.1007/s11655-011-0756-5 DOI：

Shu Lu, Ke-ji Chen, Qing-you Yang, et al. Progress in the research of Radix Astragali in treating chronic heart failure: Effective ingredients, dose-effect relationship and adverse reaction[J]. Chinese Journal of Integrative Medicine, 2011,17(6):473-477. DOI： 10.1007/s11655-011-0756-5.

摘要

Radix Astragali

a Chinese herbal medicine possessing important cardiovascular pharmacologic effects

is widely applied for the treatment of chronic heart failure (CHF) in clinical practice. This paper summarizes briefly the researches in the last 10 years on its chemical compositions

effective ingredients for improving cardiac function

dose-effect relationship in treating CHF

and adverse reactions that occurred in clinical practice.

Abstract

Radix Astragali

a Chinese herbal medicine possessing important cardiovascular pharmacologic effects

is widely applied for the treatment of chronic heart failure (CHF) in clinical practice. This paper summarizes briefly the researches in the last 10 years on its chemical compositions

effective ingredients for improving cardiac function

dose-effect relationship in treating CHF

and adverse reactions that occurred in clinical practice.

关键词

Radix Astragalieffective ingredientdose-effect relationshipAdverse Reactionreview

Keywords

Radix Astragalieffective ingredientdose-effect relationshipAdverse Reactionreview

references

National Committee of Pharmacopoeia. Pharmacopoeia of the People’s Republic of China. 2000 edtion. Beijing: China Medical Science and Technology Press; 2010:283–284.

Li R, Fu TJ, Ji QY, Ding LS, Peng SL. A study of the roots of Astragalus Mongholicus and Astragalus Membranaceus by high performance liquid chromatography-mass spectrometry. Chin J Anal Chem (Chin) 2005;33:1676–1680.

Duan YM, Xie D. Studies on the chemical components of Astragalus membranaceus and the method of determinating effectual constituent—astragaloside IV. Chin J Veterinary Drug (Chin) 2005;39:35–38.

Liang LJ, Zhao KJ, Tu PF, Jiang Y. Simultaneous determination of 4 kinds of flavonoids in Radix Astragali by HPLC. China Pharm (Chin) 2010;21:1385–1387.

Liu Y, Ma XX, Chen HB, Tu GZ, He JM, Zhao YY. Chemical constituents of Hedysarum Gmelinii. J Chin Pharm Sci (Chin) 2005;14:75–78.

Wen YH, Cheng L, Zheng D, Huang XS, Han L. Chemical constituents of Astragalus membranaceus var: mongholicus. Pract Pharm Clin Remed (Chin) 2010;13:115–119.

Wang QL, Li YY, Qi H, Sun XX, Zhang WJ, Jiang Y. Inotropic effects of astragaloside on isolated working heart and its possible mechanism. China J Chin Mater Med (Chin) 1992;17:557–559.

Liu YX, Liu ZP, Jiao JJ, Lou JS. Effects of astragaloside IV on myocardiac dynamics and cardiac function with normal and depressant cardiac function in rats. Chin Tradit Herb Drugs (Chin) 2001;32:332–334.

Lei CL, Wang XM, Jiang Y, Sun CW. Effects of Astragalus saponins on single calcium channel activities. J Norman Bethune Univ Med Sci (Chin) 1994;20:535–537.

Tan K, Yin MH. Current status of Astragalus and its preparations in pharmacology and clinical application. J Med Sci Yanbian Univ (Chin) 2007;30:146–148.

Shi HL, Wu DZ, Hu ZB. Progress in research of astragaloside. Chin Pharm J (Chin) 2008;43:565–567.

He Y. Protection of Astragalus extract on myocardial ischemia injury. Tradit Chin Drug Res Clin Pharmacol (Chin) 2008;19:100–102.

Li L, Ke L, Peng DF, Gu H. The effect of Astragalus Memberanaceus on the myocardium during anoxia. Chin J Integr Med Cardio-/Cerebrov Dis (Chin) 2003;1:79–80.

Wang W, Liu QN, Zhao XJ. Protective effects of Huangqi against ischemia/reperfusion injury in rats. J Xi’an Jiaotong Univ (Med Sci, Chin) 2009;30:712–715.

Zhou JY, Fan Y, Kong JL, Wu DZ, Hu ZB. Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats. China J Chin Mater Med (Chin) 2000;25:300–302.

Chu SL, Shi XY. Xi SF, Sun CL. Experimental studies on improving heart preservation effect of Astragalus saponins. Chin J Integr Tradit West Med (Chin) 1999; 19:482–483.

Lu YS. Comparative study on efficacy of heart failure with different doses of Astragalus injection. Jiangsu J Tradit Chin Med (Chin) 2001;22:45.

Shen AM. Treatment of heart failure with different doses of Astragalus injection. Pract Clin J Integr Tradit Chin West Med (Chin) 2002;2:22.

Qian HL, Huang LW. Effects of different doses of Astragalus on left ventricular diastolic dysfunction in patients with coronary heart disease. J Guangxi Med Univ (Chin) 2000;17:448.

Yang QY, Lu SH, Sun HR. Clinical effect of Astragalus Granule of different dosages on the quality of life in patients with chronic heart failure. Chin J Integr Med 2011;17:146–149.

Zhou ZL, Yu P, Lin D, Liang LZ, Lin P. Study on effect of Astragalus injection in treating congestive heart failure. Chin J Integr Tradit West Med (Chin) 2001;21:747–749.

Liu GH, Meng QZ, Chen Y, Ji DY, Gao SR. Observation on curative effects of nitroglycerin combined with astragalus injection on cardiac functional insufficiency. Chin J Integr Tradit Chin West Med Intensive Crit Care (Chin)1999;6:246–247.

Zheng PL, Dai JY, Chen H, Fu WP, Zhang C, Su J, et al. Influence of astragaloside IV (ASIV) on systolic and diastolic function in dogs with acute heart failure. Chin Pharmacol Bull (Chin) 2005;21:1534–1535.

Li SR, Hao JF, Wang Y, Gao XM, Hu LM. Experimental research about the influence of Huangqi Inject on hemodynamics in rats with acute heart failure. Tianjin J Tradit Chin Med (Chin) 2003;20:56–57.

Wu WP. Experiment study on positive inotropic action of astragaloside IV, an active ingredient of Radix Astragali. J Chin Med Mater (Chin) 2005;28:591–592.

Zhong GG, Sun XX, Li YY, Jiang Y, Wei YD, An ZY. Positive inotropic action of Astragalus membranaceus saponins on isolated working heart. J Norman Bethune Univ (Med Sci, Chin) 1994;20:448–449.

Sun CW, Lei CL, Lu WW, Chen Y, Wu Y. Effects of Astragalus saponins on experimental heart failure. J Norman Bethune Univ (Med Sci, Chin) 1994;20:125–127.

Zhao J. Scarlet fever-like drug eruption caused by Astragalus—a case report. J Clin Dermatol (Chin) 2000;29:333.

Tan JC, Li B. Allergic reaction caused by Astragalus Decoction—a case report. Shaanxi J Tradit Chin Med (Chin) 2003;24:74.

Shi P, Gu JH. One case of headache caused by Astragalus. Chengdu Med (Chin) 1998;24:118.

Wang CH, Zhang JJ. An analysis of hypertension induced by large dose of Astragalus in 5 patients. Shandong J Tradit Chin Med (Chin)1996;15:351.

Shi XM. Large dose of Astragalus-induced severe limb pain. Shaanxi J Tradit Chin Med (Chin) 1991;12:182.

Yang ZG. Pyrogen reaction caused by intravenous dripping of Astragalus: 3 cases report. Tradit Chin Drug Res Clin Pharmacol (Chin) 2003;14:170.

Xu BS. Anaphylactic shock secondary to Huangqi Injection: 2 case reports. Adv Drug React J (Chin) 2004;5:344.

Gu ZP. Two cases of acute urticaria caused by Astragalus injection. Herald Med (Chin) 2004;23:608.

Wan JQ. Acute asthmatic reaction induced by Di’ao Astragalus injection-2 cases report. New J Tradit Chin Med (Chin) 2001;33:16.

Wang XL, Liu XL. Analysis of ADR cases induced by Huangqi Injection. Hebei Med (Chin) 2006;12:877–878.

Fu ZF, Zhang JH, Shang HC, Gao XM. Analysis on case suffered from adverse reactions of Huangqi Injection. Drug Evaluat Res (Chin) 2009;32:54–61.

Wu JR, Zhang B, Jia LH. Literature research of adverse reactions induced by Astragalus injection based on database analysis. Asia-Pacific Tradit Med (Chin) 2009;5:157–159.

FULL TEXT LINK

More>

浏览量

784

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Review of the regulations for clinical research in herbal medicines in USA

History of Chinese medicinal wine

Progress on the application of aquaporins in Chinese medicine

The progress of the research on cardio-vascular effects and acting mechanism of polydatin

Current progress of research on pharmacologic actions of salvianolic acid B