Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

Ba-si Ouyang; Jie Gao; Jian-li Che; Yin Zhang; Jun Li; Hai-zhou Yang; Tian-yan Hu; Man Yang; Yuan-jian Wu; Ling-ling Ji

doi:10.1007/s11655-011-0783-2

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Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

OriginalPaper | Updated：2021-08-27

- Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis
- Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis
- 中国结合医学杂志（英文版） 2011年17卷第7期页码：505-509
- Affiliations：
  
  1. Suzhou Hospital of Traditional Chinese Medicine,Jiangsu Province,Suzhou,China
  2. First Affiliated Hospital of Soochow University,Jiangsu Province,Suzhou,China
  3. Children’s Hospital of Soochow University,Jiangsu Province,China
  4. Nanjing University of Traditional Chinese Medicine,Nanjing,China
- Author bio：
- Funds：
  
  Supported by the Suzhou Municipal Developing Plan of Sciences and Technology (Social Development and Three-drug Keystone, No. SS0528)
- DOI：10.1007/s11655-011-0783-2
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-7-3，
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Ouyang, Bs., Gao, J., Che, Jl. et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 505–509 (2011). https://doi.org/10.1007/s11655-011-0783-2

Ba-si Ouyang, Jie Gao, Jian-li Che, et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 2011,17(7):505-509.
Ouyang, Bs., Gao, J., Che, Jl. et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 505–509 (2011). https://doi.org/10.1007/s11655-011-0783-2 DOI：

Ba-si Ouyang, Jie Gao, Jian-li Che, et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 2011,17(7):505-509. DOI： 10.1007/s11655-011-0783-2.

摘要

To observe the effect of electro-acupuncture (EA) on tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral blood and joint synovia in patients with rheumatoid arthritis (RA) to verify the clinical efficacy of EA. Adopting randomized controlled principle

the 63 RA patients enrolled were assigned to two groups

the 32 patients in the EA group were treated with EA

and the 31 patients in the simple needling (SN) group treated with simple needling. According to the integral-local combining method

the acupoints were selected mainly from yang-meridian and local Ashi points (pain-point). EA or SN was applied every other day

10 times as a course

and each patient received a total of 3 courses of treatment. Blood and synovial levels of TNF-α and VEGF were reduced significantly after treatment in both groups. The lowering (absolute value and difference value) of TNF-α as well as the absolute value of VEGF

either in blood or in synovia

were similar in the two groups (P>0.05); but the lowering of VEGF after treatment was more significant in the EA group than that in the SN group (P<0.05). EA could effectively lower the contents of TNF-α and VEGF in peripheral blood and joint synovia to improve the internal environment for genesis and development of RA

so as to enhance the clinical therapeutic effectiveness.

Abstract

the 63 RA patients enrolled were assigned to two groups

the 32 patients in the EA group were treated with EA

and the 31 patients in the simple needling (SN) group treated with simple needling. According to the integral-local combining method

the acupoints were selected mainly from yang-meridian and local Ashi points (pain-point). EA or SN was applied every other day

10 times as a course

either in blood or in synovia

so as to enhance the clinical therapeutic effectiveness.

关键词

electro-acupunctureneedlingrheumatoid arthritistumor necrosis factorvascular endothelial growth factor

Keywords

electro-acupunctureneedlingrheumatoid arthritistumor necrosis factorvascular endothelial growth factor

references

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