A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)

Quan Jiang; Xin-yao Zhou; Lei Wang; Wei Yu; Ping Wang; Wei Cao; Xiao-po Tang

doi:10.1007/s11655-011-0793-0

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A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)

OriginalPaper | Updated：2021-08-27

- A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)
- A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)
- 中国结合医学杂志（英文版） 2012年18卷第4期页码：256-261
- Affiliations：
  
  1. School of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. Department of Radiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  4. Department of Radiology, Beijing Union Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by Capital Development Fund for Medical Research (No. 2005-SF-I-010)
- DOI：10.1007/s11655-011-0793-0
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2011-8-18，
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Jiang, Q., Zhou, Xy., Wang, L. et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)., Chin. J. Integr. Med. 18, 256–261 (2012). https://doi.org/10.1007/s11655-011-0793-0

Quan Jiang, Xin-yao Zhou, Lei Wang, et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)[J]. Chinese Journal of Integrative Medicine, 2012,18(4):256-261.
Jiang, Q., Zhou, Xy., Wang, L. et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)., Chin. J. Integr. Med. 18, 256–261 (2012). https://doi.org/10.1007/s11655-011-0793-0 DOI：

Quan Jiang, Xin-yao Zhou, Lei Wang, et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)[J]. Chinese Journal of Integrative Medicine, 2012,18(4):256-261. DOI： 10.1007/s11655-011-0793-0.

摘要

To investigate the effects of Qingre Huoxue Decoction 清热活血方

clearing heat and promoting blood flow; QRHXD)

on the radiographic progression in patients with rheumatoid arthritis (RA) by X-ray imaging. Eighty-six patients with active RA diagnosed as damp-heat and blood stasis syndrome were randomized into a QRHXD group and a QRHXD plus methotrexate (MTX) group

with 43 cases in each group. After one-year of treatment

21 cases in each group (42 in total) were evaluated. Radiographs of hands were obtained at the baseline and after 12 months of treatment. Images were evaluated by investigators blinded to chronology and clinical data

and assessed according to the Sharp/Van der Heijde methods. High intrareader agreements were reached (mean intraobserver intraclass coefficients: 0.95). No significant change in any imaging parameters of joint destruction was observed at 12 months in either group; and the differences between the two groups were not significant (P>0.05). The mean of the changing score in the QRHXD group was 3.5±4.1

and 2.4±3.5 in the QRHXD+MTX group

while the baseline radiographic score of patients in the QRHXD group was relatively higher (18.9±19.1 vs. 14.0±14.0). The mean rates of the changing scores of the two groups were similar (0.24±0.28 vs. 0.25±0.44

P=0.40). The severity of progression in the two groups was also similar (P=0.46)

7 cases without radiographic progression in the QRHXD group and 8 in the QRHXD+MTX group

3 cases with obvious radiographic progression in the QRHXD group and 1 in the QRHXD+MTX group. Radiographic progression of RA patients in both groups is similar

indicating that the QRHXD Decoction has a potential role in preventing bone destruction.

Abstract

To investigate the effects of Qingre Huoxue Decoction 清热活血方

clearing heat and promoting blood flow; QRHXD)

with 43 cases in each group. After one-year of treatment

and 2.4±3.5 in the QRHXD+MTX group

P=0.40). The severity of progression in the two groups was also similar (P=0.46)

7 cases without radiographic progression in the QRHXD group and 8 in the QRHXD+MTX group

3 cases with obvious radiographic progression in the QRHXD group and 1 in the QRHXD+MTX group. Radiographic progression of RA patients in both groups is similar

indicating that the QRHXD Decoction has a potential role in preventing bone destruction.

关键词

rheumatoid arthritisQingre Huoxue DecoctionChinese Medicineherbradiologybone destruction

Keywords

rheumatoid arthritisQingre Huoxue DecoctionChinese Medicineherbradiologybone destruction

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