Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer

Bo Cao; Shao-tang Li; Zhi Li; Wen-ling Deng

doi:10.1007/s11655-011-0822-z

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Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer

OriginalPaper | Updated：2021-08-27

- Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer
- Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer
- 中国结合医学杂志（英文版） 2011年17卷第8期页码：593-599
- Affiliations：
  
  1. Department of Colorectal and Anal Surgery, the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang,China
  2. Department of Colorectal Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Colorectal Cancer Center of Shanghai Jiaotong University,Shanghai,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0822-z
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-8-9，
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Cao, B., Li, St., Li, Z. et al. Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer., Chin. J. Integr. Med. 17, 593 (2011). https://doi.org/10.1007/s11655-011-0822-z

Bo Cao, Shao-tang Li, Zhi Li, et al. Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer[J]. Chinese Journal of Integrative Medicine, 2011,17(8):593-599.
Cao, B., Li, St., Li, Z. et al. Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer., Chin. J. Integr. Med. 17, 593 (2011). https://doi.org/10.1007/s11655-011-0822-z DOI：

Bo Cao, Shao-tang Li, Zhi Li, et al. Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer[J]. Chinese Journal of Integrative Medicine, 2011,17(8):593-599. DOI： 10.1007/s11655-011-0822-z.

摘要

To evaluate the efficacy and safety of Yiqi Zhuyu Decoction (益气逐瘀汤

YZD) combined with oxaliplatin plus 5-flurouracil/leucovorin (FOLFOX-4) in the patients with metastatic colorectal cancer (MCRC). A total of 120 patients with MCRC were randomly divided into the experimental group (FOLFOX-4 plus YZD

60 cases) and the control group (FOLFOX-4 plus placebo

60 cases)

according to the sequence of hospitalization from January 2005 to December 2007. The treatment was supposed to be continued until disease progression (PD) or for 48 weeks (i.e.

up to 24 cycles of FOLFOX-4). Response rate (RR)

progression-free survival (PFS)

overall survival (OS) and adverse events (AEs) were observed. RR was 41.5% in the experimental group and 34.0% in the control group [odds ratio (OR): 1.18

95% CI: 0.77 to 1.82

P=0.432]. Median PFS were 9.0 months and 8.0 months

respectively [hazard ratio (HR): 0.78

95% CI: 0.53 to 1.15

P=0.215]. Median OS were 21.0 months and 18.0 months (HR: 0.65

95% CI: 0.43 to 0.99

P=0.043) and grade 3/4 AEs were 56.6% and 76.7% (OR: 0.61

95% CI: 0.18 to 0.87

P=0.020)

respectively. YZD combined with FOLFOX-4 chemotherapy significantly improved OS in this first-line trial in the patients with MCRC and significantly decreased grade 3/4 AEs. However

RR was not improved

and PFS did not reach statistical significance by the addition of YZD. The treatment of YZD combined with FOLFOX-4 may be necessary in order to optimize efficacy and safety.

Abstract

To evaluate the efficacy and safety of Yiqi Zhuyu Decoction (益气逐瘀汤

60 cases) and the control group (FOLFOX-4 plus placebo

60 cases)

according to the sequence of hospitalization from January 2005 to December 2007. The treatment was supposed to be continued until disease progression (PD) or for 48 weeks (i.e.

up to 24 cycles of FOLFOX-4). Response rate (RR)

progression-free survival (PFS)

overall survival (OS) and adverse events (AEs) were observed. RR was 41.5% in the experimental group and 34.0% in the control group [odds ratio (OR): 1.18

95% CI: 0.77 to 1.82

P=0.432]. Median PFS were 9.0 months and 8.0 months

respectively [hazard ratio (HR): 0.78

95% CI: 0.53 to 1.15

P=0.215]. Median OS were 21.0 months and 18.0 months (HR: 0.65

95% CI: 0.43 to 0.99

P=0.043) and grade 3/4 AEs were 56.6% and 76.7% (OR: 0.61

95% CI: 0.18 to 0.87

P=0.020)

respectively. YZD combined with FOLFOX-4 chemotherapy significantly improved OS in this first-line trial in the patients with MCRC and significantly decreased grade 3/4 AEs. However

RR was not improved

and PFS did not reach statistical significance by the addition of YZD. The treatment of YZD combined with FOLFOX-4 may be necessary in order to optimize efficacy and safety.

关键词

colorectal cancerchemotherapyFOLFOX-4Chinese MedicineYiqi Zhuyu Decoction

Keywords

colorectal cancerchemotherapyFOLFOX-4Chinese MedicineYiqi Zhuyu Decoction

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