Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

Xin Mou; Wen-hong Liu; Dan-yang Zhou; Ying-hui Liu; Yong-bin Hu; Guo-ling Ma; Cheng-min Shou; Jia-wei Chen; Jin-xi Zhao

doi:10.1007/s11655-011-0845-5

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Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

OriginalPaper | Updated：2021-08-27

- Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism
- Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism
- 中国结合医学杂志（英文版） 2011年17卷第9期页码：680-684
- Affiliations：
  
  1. Department of Endocrinology of Hangzhou Red Cross Hospital,Hangzhou,China
  2. Zhejiang University of Chinese Medicine,Hangzhou,China
  3. Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30801467) and Zhejiang Provincial Natural Science Foundation of China (No. Y2080683)
- DOI：10.1007/s11655-011-0845-5
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-9-11，
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Mou, X., Liu, Wh., Zhou, Dy. et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism., Chin. J. Integr. Med. 17, 680 (2011). https://doi.org/10.1007/s11655-011-0845-5

Xin Mou, Wen-hong Liu, Dan-yang Zhou, et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism[J]. Chinese Journal of Integrative Medicine, 2011,17(9):680-684.
Mou, X., Liu, Wh., Zhou, Dy. et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism., Chin. J. Integr. Med. 17, 680 (2011). https://doi.org/10.1007/s11655-011-0845-5 DOI：

Xin Mou, Wen-hong Liu, Dan-yang Zhou, et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism[J]. Chinese Journal of Integrative Medicine, 2011,17(9):680-684. DOI： 10.1007/s11655-011-0845-5.

摘要

To explore the association of Chinese medicine constitution susceptibility to diabetic nephropathy (DN) and transforming growth factor (TGF)-β1 (T869C) gene polymorphism. TGF-β1 gene polymorphism detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was screened for 180 DN cases and 180 type 2 diabetic mellitus (T2DM) cases without combined DN. Patients with DN were surveyed epidemiologically with constitution in the Chinese medicine questionnaire (CCMQ). Binary logistic regression analysis was utilized to study the correlation between nine types of Chinese medicine constitution and TGF-β1 (T869C) gene polymorphisms. The DN group has a higher frequency of TGF-β1 (T869C) gene polymorphism than the T2DM group

and CC/CT genotypes than the T2DM group [CC

TT (DN group): 88

5 (cases) versus (T2DM group) 71

36 (cases)

P<0.05]. The phlegm-dampness constitution

damp-heat constitution

and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism. Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism

a potential predictor of susceptibility to DN in T2DM patients.

Abstract

and CC/CT genotypes than the T2DM group [CC

TT (DN group): 88

5 (cases) versus (T2DM group) 71

36 (cases)

P<0.05]. The phlegm-dampness constitution

damp-heat constitution

and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism. Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism

a potential predictor of susceptibility to DN in T2DM patients.

关键词

diabetic nephropathygene polymorphismtransforming growth factor-β1Chinese medicine constitution

Keywords

diabetic nephropathygene polymorphismtransforming growth factor-β1Chinese medicine constitution

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