Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome

Guo-lin Wu; Tian-yi Li; Yong-sheng Fan; Guo-you Yu

doi:10.1007/s11655-011-0850-8

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Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome

OriginalPaper | Updated：2021-08-27

- Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
- Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
- 中国结合医学杂志（英文版） 2011年17卷第9期页码：710-714
- Affiliations：
  
  1. The First Affiliated Hospital of Medical School of Zhejiang University,Hangzhou,China
  2. Zhejiang Chinese Medical University,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0850-8
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-9-11，
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Wu, Gl., Li, Ty., Fan, Ys. et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome., Chin. J. Integr. Med. 17, 710 (2011). https://doi.org/10.1007/s11655-011-0850-8

Guo-lin Wu, Tian-yi Li, Yong-sheng Fan, et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome[J]. Chinese Journal of Integrative Medicine, 2011,17(9):710-714.
Wu, Gl., Li, Ty., Fan, Ys. et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome., Chin. J. Integr. Med. 17, 710 (2011). https://doi.org/10.1007/s11655-011-0850-8 DOI：

Guo-lin Wu, Tian-yi Li, Yong-sheng Fan, et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome[J]. Chinese Journal of Integrative Medicine, 2011,17(9):710-714. DOI： 10.1007/s11655-011-0850-8.

摘要

To observe the therapeutic effect of Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment

immunoglobulin G (IgG) level

erythrocyte sedimentation rate (ESR)

and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Before treatment

levels of IgG

ESR

and OPN in patients were higher than those in the normal control. After 3 months of treatment

those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore

there was a positive correlation between the levels of OPN and the levels of IgG and ESR

and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis could alleviate pSS disease and improve the QOL. In addition

the OPN level might be used as an evaluating index for pSS disease.

Abstract

To observe the therapeutic effect of Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment

immunoglobulin G (IgG) level

erythrocyte sedimentation rate (ESR)

levels of IgG

ESR

and OPN in patients were higher than those in the normal control. After 3 months of treatment

there was a positive correlation between the levels of OPN and the levels of IgG and ESR

and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis could alleviate pSS disease and improve the QOL. In addition

the OPN level might be used as an evaluating index for pSS disease.

关键词

primary Sjogren's syndromeChinese Herbal Medicinestrengthening qinourishing Yinremoving stasisquality of life

Keywords

primary Sjogren's syndromeChinese Herbal Medicinestrengthening qinourishing Yinremoving stasisquality of life

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