Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis

Yun-xiang Cao; Jian Liu; Yan Zhu

doi:10.1007/s11655-011-0873-1

Your Location：

Home >

Browse articles >

Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis

OriginalPaper | Updated：2021-08-27

- Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis
- Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis
- 中国结合医学杂志（英文版） 2011年17卷第10期页码：738-743
- Affiliations：
  
  Department of Rheumatology, The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei,China
- Author bio：
- Funds：
  
  Supported by the National Key Discipline of Traditional Chinese Medicine Project for Bi Diseases [Administration of Traditional Chinese Medicine, China (2009) No. 30], Program of Science and Technology Department of Anhui Province, China (No. 07010300204), and Traditional Chinese Medicine Research Project of Health Department of Anhui Province, China (No. 2009ZY05)
- DOI：10.1007/s11655-011-0873-1
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2013-3-26，
Scan for full text
Cao, Yx., Liu, J. & Zhu, Y. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 738–743 (2011). https://doi.org/10.1007/s11655-011-0873-1

Yun-xiang Cao, Jian Liu, Yan Zhu. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 2011,17(10):738-743.
Cao, Yx., Liu, J. & Zhu, Y. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 738–743 (2011). https://doi.org/10.1007/s11655-011-0873-1 DOI：

Yun-xiang Cao, Jian Liu, Yan Zhu. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis[J]. Chinese Journal of Integrative Medicine, 2011,17(10):738-743. DOI： 10.1007/s11655-011-0873-1.

摘要

To study the changes in cardiac function of rheumatoid arthritis (RA) patients and: to observe the effect of Xinfeng Capsule (新风胶囊

XFC) on them. Sixty-eight RA patients were: randomly assigned to two groups by a lottery: 38 patients in the treatment group treated orally with XFC

3 capsules

thrice a day

and 30 in the control group treated with Fengshi Gutong Capsule (风湿骨痛胶囊

FSGTC)

4 capsules

twice a day

30 days as one course of treatment

and two courses were given for both groups. A normal control (NC) group including 20 healthy subjects was set up. The clinical efficacy was compared between the two treated groups. The changes in cardiac function

including early diastolic peak flow velocity (E)

late diastolic peak flow velocity (A)

left ventricular fraction shortening (FS)

and E/A

as well as uric acid (UA)

erythrocyte sedimentation rate (ESR)

α-acid glycoprotein (α-AGP)

and hypersensitive C-reaction protein (hs-CRP)

were observed. The regulation T cell was determined with flow cytometry. (1) The total effective rate in the treatment group and the control group was 92.1%: (35/38) and 70.0% (21/30)

respectively. Significant difference was shown between them (P<0.05). (2) <Compared with those of the NC group

E peak

E/A ratio

and FS of RA patients were lower (P<0.01)

while <A peak was higher (P<0.01). Moreover

A peak of the treatment group after treatment was significantly lower <(P<0.05) and E/A ratio was significantly higher (<P<0.05) as compared with those of the control group. (3) The <improvement in the treatment group in reducing UA and hs-CRP was superior to those of the control group (P<0.05). In addition

the improvement in α-AGP

CD4 <CD4+CD25 CD25+ Treg

and CD4 CD4+CD25 CD25+CD127 CD127−Treg of the treatment group was obvious as compared with the control group

although the difference was not statistically significant. The descendent of cardiac function exists in RA patients. XFC could improve cardiac: function of RA patients

which is superior to FSGTC. Its mechanism may be related to its effect on raising CD4 CD4+CD25 CD25+Treg and CD4 CD4+CD25 CD25+CD127− Treg cells

decreasing UA

α-AGP

and hs-CRP levels

reducing immune inflammation

adjusting the overall balance of immune response

and thus improving the cardiac function of RA patients.

Abstract

To study the changes in cardiac function of rheumatoid arthritis (RA) patients and: to observe the effect of Xinfeng Capsule (新风胶囊

XFC) on them. Sixty-eight RA patients were: randomly assigned to two groups by a lottery: 38 patients in the treatment group treated orally with XFC

3 capsules

thrice a day

and 30 in the control group treated with Fengshi Gutong Capsule (风湿骨痛胶囊

FSGTC)

4 capsules

twice a day

30 days as one course of treatment

including early diastolic peak flow velocity (E)

late diastolic peak flow velocity (A)

left ventricular fraction shortening (FS)

and E/A

as well as uric acid (UA)

erythrocyte sedimentation rate (ESR)

α-acid glycoprotein (α-AGP)

and hypersensitive C-reaction protein (hs-CRP)

were observed. The regulation T cell was determined with flow cytometry. (1) The total effective rate in the treatment group and the control group was 92.1%: (35/38) and 70.0% (21/30)

respectively. Significant difference was shown between them (P<0.05). (2) <Compared with those of the NC group

E peak

E/A ratio

and FS of RA patients were lower (P<0.01)

while <A peak was higher (P<0.01). Moreover

the improvement in α-AGP

CD4 <CD4+CD25 CD25+ Treg

and CD4 CD4+CD25 CD25+CD127 CD127−Treg of the treatment group was obvious as compared with the control group

although the difference was not statistically significant. The descendent of cardiac function exists in RA patients. XFC could improve cardiac: function of RA patients

which is superior to FSGTC. Its mechanism may be related to its effect on raising CD4 CD4+CD25 CD25+Treg and CD4 CD4+CD25 CD25+CD127− Treg cells

decreasing UA

α-AGP

and hs-CRP levels

reducing immune inflammation

adjusting the overall balance of immune response

and thus improving the cardiac function of RA patients.

关键词

rheumatoid arthritiscardiac functionregulation T cellinflammatory factorXinfeng Capsule

Keywords

rheumatoid arthritiscardiac functionregulation T cellinflammatory factorXinfeng Capsule

references

van Halm VP, Peters MJ, Voskuyl AE, Boers M, Lems WF, Visser M, et al. Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease, a cross sectional study: the CARRE Investigation. Ann Rheum Dis 2009;68:1395–1400,1578.

Chinese Society of Rheumatology, Chinese Medical Association. Guidelines for the treatment of rheumatoid arthritis. Chin J Rheumatol (Chin) 2003;7:250–254.

Zhou YC, Guo WX, eds. Ultrasonic medicine. Beijing: Scientific and Technology Publishing House; 2006:682–685.

Chen RL, Liu J, Pan YZ, Zhu HM. The changes and significance of CD4+CD25+CD127-regulatory T cells in patients with rheumatoid arthritis. Chin J Clin Healthcare (Chin) 2008;6:606–608.

Zheng XY, ed. Guiding principle for clinical research on new drugs of traditional Chinese medicine. Beijing: China Medical Science and Technology Press; 2002:115–119.

Solomon DH, Avorn J, Stürmer T, Glynn RJ, Mogun H, Schneeweiss S. Cardiovascular outcomes in new users of coxibs and non-steroidal anti-inflammatory drugs (NSAIDs). Arthritis Rheum 2006;54:1378–1389.

Cheng X, Liao YH, Zheng JE, Xia CY, Wang CH, Zhou ZH et al. Significance of the change of CD4+CD25+ regulatory T cells in patients with unstable angina. Mol Cardiol China (Chin) 2006;6:17–19.

Peters MJ, van Halm VP, Voskuyl AE, Smulders YM, Boers M, Lems WF, et al. Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? Arthritis Rheum 2009;61:1571–1579.

Panoulas VF, Milionis HJ, Douglas KM, Nightingale P, Kita MD, Klocke R, et al. Association of serum uric acid with cardiovascular disease in rheumatoid arthritis. Rheumatology (Oxford) 2007;46:1466–1570.

Liu J, Zheng ZJ. Discussion of mechanism of rheumatoid arthritis in traditional Chinese medicine. Chin J Basic Med Tradit Chin Med (Chin) 2001;7:13.

Liu J, Zheng ZJ, Han MX, Fang CH, Cui YW, Lei L, et al. Experimental study on the effects of Xinfeng Capsule on ultrastructure of synovial cells and thymocytes in adjuvant arthritis rats. China J Tradit Chin Med Pharm (Chin) 2002;17:159–161.

Liu J, Fan HX, Yang MY. Clinical study on rheumatoid arthritis treated with Xinfeng Capsule. Chin J Tradit Med Sci Technol (Chin) 2007;14:389–391.

Liu J, Yu XF, Zong RK. Effects of Xinfeng Capsule on behaviors and myocardial ultrastructure in adjuvant arthritis rats. J Chin Integr Med (Chin) 2008;6:606–610.

Ma J, Wang ZR, Long Y, Fan AL, Wang SS, Li JH. Protective effect of milkvetch root and danshen root compound preparation on injury of oxygen free radicals in myocardial mitochondria of rats. Chin J Clin Rehabil (Chin) 2006;10:55–58.

Wang B, Jiang BR, Zhou SN. Clinical research on the treatment of cardiovascular disease by Astragalus. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2005;3:162–164.

Xu CJ, Song L, Yin XQ, Guo ZY, Yang J. Influence of triptolide on the proliferation and proα1 (I) collagen synthesis in cultured neonatal rat myocardial fibroblast stimulated by angiotensin II. Chin J Clin Pharmacol Ther (Chin) 2008;13:499–501.

Zhao ZG, Li JY, Jiang H, Wang GY, Zhang JP, Chu L. Influence of centipede acidic protein on cardiac function in rats with acute heart failure. J Beijing Univ Tradit Chin Med (Chin) 2008;31:106–109.

Zheng HZ, Dong ZH, She J, eds. Modern study of traditional Chinese medicine. Vol 5. Beijing: Academy Press; 1998:4492.

Wen CH, Xu XH, Zhou ZT, Lu MQ, Feng XQ. Clinical observation on the prevention of anthracycline-associated cardiotoxity by semen coicis oil injection. Tumor (Chin) 2009;29:1003–1005.

FULL TEXT LINK

More>

浏览量

881

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

The potential role of Chinese medicine in ameliorating extra-articular manifestations of rheumatoid arthritis

Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial

How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?

Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine