An innovative herbal product for the prevention of osteoporosis

Ping-chung Leung; King-fai Cheng; Yat-heung Chan

doi:10.1007/s11655-011-0876-y

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An innovative herbal product for the prevention of osteoporosis

OriginalPaper | Updated：2021-08-27

- An innovative herbal product for the prevention of osteoporosis
- An innovative herbal product for the prevention of osteoporosis
- 中国结合医学杂志（英文版） 2011年17卷第10期页码：744-749
- Affiliations：
  
  1. Institute of Chinese Medicine, The Chinese University of Hong Kong,Hong Kong,China
  2. Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong,Hong Kong,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0876-y
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2013-3-26，
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Leung, Pc., Cheng, Kf. & Chan, Yh. An innovative herbal product for the prevention of osteoporosis., Chin. J. Integr. Med. 17, 744–749 (2011). https://doi.org/10.1007/s11655-011-0876-y

Ping-chung Leung, King-fai Cheng, Yat-heung Chan. An innovative herbal product for the prevention of osteoporosis[J]. Chinese Journal of Integrative Medicine, 2011,17(10):744-749.
Leung, Pc., Cheng, Kf. & Chan, Yh. An innovative herbal product for the prevention of osteoporosis., Chin. J. Integr. Med. 17, 744–749 (2011). https://doi.org/10.1007/s11655-011-0876-y DOI：

Ping-chung Leung, King-fai Cheng, Yat-heung Chan. An innovative herbal product for the prevention of osteoporosis[J]. Chinese Journal of Integrative Medicine, 2011,17(10):744-749. DOI： 10.1007/s11655-011-0876-y.

摘要

To prevent the deterioration of osteopenia

a triple herb product Bo-gu Ling (补骨灵

ELP) was created for a clinical trial on post-menopausal women suffering from osteopenia. The design of the clinical trial was of randomized

double-blind

placebo-controlled nature. A total of 150 women aged 40–60 years

who were after menopause for at least 1 year and their lumbar spine bone mineral density (BMD) must be lower than 0.891 g/cm2

were recruited and randomly divided into the ELP group treated with ELP and the placebo group

with 75 in each group. The primary endpoint was the BMD of the lumbar spine that was assessed at baseline

6 and 12 months after treatment. Secondary endpoints included peripheral quantitative computed tomography (pQCT) measurements of distal tibia and the changes in the quality of life (QOL). The spine BMD of the ELP group was increased by 0.69% in the subjects who were more than 10 years after menopause. In contrast

the placebo group of the same stratum decreased by 0.61% (P=0.067). In the subjects with more than 10 years duration of menopause

the hip BMD increased by 0.21% in the ELP group

compared with a decrease of 0.52% in the placebo group (P=0.159). The tibia strengthstrain index was increased by 1.94% in the ELP group compared with 0.33% in the placebo group (P=0.047). Physical function of SF-36 QOL questionnaire was remarkably improved compared with the baseline

but did not show dominance over the placebo group. ELP showed potential benefifit in improving BMD on the women who experienced over 10 years of menopause.

Abstract

To prevent the deterioration of osteopenia

a triple herb product Bo-gu Ling (补骨灵

ELP) was created for a clinical trial on post-menopausal women suffering from osteopenia. The design of the clinical trial was of randomized

double-blind

placebo-controlled nature. A total of 150 women aged 40–60 years

who were after menopause for at least 1 year and their lumbar spine bone mineral density (BMD) must be lower than 0.891 g/cm2

were recruited and randomly divided into the ELP group treated with ELP and the placebo group

with 75 in each group. The primary endpoint was the BMD of the lumbar spine that was assessed at baseline

the placebo group of the same stratum decreased by 0.61% (P=0.067). In the subjects with more than 10 years duration of menopause

the hip BMD increased by 0.21% in the ELP group

but did not show dominance over the placebo group. ELP showed potential benefifit in improving BMD on the women who experienced over 10 years of menopause.

关键词

prevention of osteoporosisHerbal ProductBone Mineral Density

Keywords

prevention of osteoporosisHerbal ProductBone Mineral Density

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