FOLLOWUS
Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
纸质出版日期:2011,
网络出版日期:2013-3-26,
Scan for full text
Wang, B., Lin, L., Ni, Q. et al. Chinese Medicine for Treating Diabetic Nephropathy., Chin. J. Integr. Med. 17, 794–800 (2011). https://doi.org/10.1007/s11655-011-0880-2
Bin Wang, Lan Lin, Qing Ni, et al. Chinese Medicine for Treating Diabetic Nephropathy[J]. Chinese Journal of Integrative Medicine, 2011,17(10):794-800.
Wang, B., Lin, L., Ni, Q. et al. Chinese Medicine for Treating Diabetic Nephropathy., Chin. J. Integr. Med. 17, 794–800 (2011). https://doi.org/10.1007/s11655-011-0880-2 DOI:
Bin Wang, Lan Lin, Qing Ni, et al. Chinese Medicine for Treating Diabetic Nephropathy[J]. Chinese Journal of Integrative Medicine, 2011,17(10):794-800. DOI: 10.1007/s11655-011-0880-2.
Diabetic nephropathy is one of the main causes of renal end-stage disease. The pathogenesis of diabetic nephropathy is complex. The current treatment is only for a particular cause without multi-target therapeutic drugs. Chinese medicine is a great treasure with multi-component complex drugs interacting with multiple targets and functions. This paper reviewed the protective effect of Chinese medicine for treating diabetic nephropathy in clinical studies
in vivo studies
and in vitro studies. The possible mechanisms
the major compounds and active crude drugs were also summarized. It was shown that Chinese medicine could not only relieve several symptoms and improve the quality of life
but also reduce the levels of proteinuria and kidney damage
and further improve renal function via multiple pathways based on the whole human system. Moreover
there were no reports of severe adverse reactions during the treatment.
Diabetic nephropathy is one of the main causes of renal end-stage disease. The pathogenesis of diabetic nephropathy is complex. The current treatment is only for a particular cause without multi-target therapeutic drugs. Chinese medicine is a great treasure with multi-component complex drugs interacting with multiple targets and functions. This paper reviewed the protective effect of Chinese medicine for treating diabetic nephropathy in clinical studies
in vivo studies
and in vitro studies. The possible mechanisms
the major compounds and active crude drugs were also summarized. It was shown that Chinese medicine could not only relieve several symptoms and improve the quality of life
but also reduce the levels of proteinuria and kidney damage
and further improve renal function via multiple pathways based on the whole human system. Moreover
there were no reports of severe adverse reactions during the treatment.
diabetic nephropathyChinese Medicinein vivo studyin vitro study
diabetic nephropathyChinese Medicinein vivo studyin vitro study
Lehmann R, Schleicher ED. Molecular mechanism of diabetic nephropathy. Clin Chim Acta 2000;297:135–144.
Vivian EM, Rubinstein GB. Pharmacologic management of diabetic nephropathy. Clin Ther 2002;24:1741–1756.
Cao Y, Jiang Y, Zhang QP. Clinical observation of 18 patients with diabetic nephropathy patients with Bawei Dihuang Pill. Shaanxi J Tradit Chin Med (Chin) 1996;17:363.
Yamabe N, Yokozawa T. Activity of the Chinese prescription Hachimi-jio-gan against renal damage in the Otsuka longevans Tokushima fatty rat: a model of clinical type 2 diabetes mellitus. J Pharm Pharmacol 2006;58:535–545.
Yokozawa T, Yamabe N, Cho EJ, Nakagawa T, Oowada S. A study on the effects to diabetic nephropathy of Hachimi-jio-gan in rats. Nephron Exp Nephrol 2004;97:38–48.
Yokozawa T, Yamabe N, Kang KS, Park CH. Efficacy-based identification of active component of Hachimi-jio-gan ameliorating diabetic nephropathy. J Tradit Med 2009;26:221-229.
Park CH, Noh JS, Tanaka T, Yokozawa T. Effects of morroniside isolated from Corni Fructus on renal lipids and inflammation in type 2 diabetic mice. J Pharm Pharmacol 2010;62:374–380.
Noh JS, Park CH, Kim HY, Zhao Q, Yamabe N, Matsumoto K, et al. Chinese prescription Kangen-karyu prevents dyslipidaemia and oxidative stress in mouse model of type 2 diabetes. J Pharm Pharmacol 2011;63:111–119.
Yokozawa T, Kim YA, Kim HY, Okamoto T, Sei Y. Protective effect of the Chinese prescription Kangen-karyu against high glucose-induced oxidative stress in LLC-PK1 cells. J Ethnopharmacol 2007;109:113–120.
He LZ, Li XM. Treatment of 20 patients with diabetic nephropathy by administration of Guizhi Fuling Pill. J Tradit Chin Med (Chin) 2001;11:584.
Nakagawa T, Yokozawa T, Oya T, Sasahara M, Terasawa K. Evaluation of Keishi-bukuryo-gan in a diabetic nephropathy model by comparison with aminoguanidine, butylated hydroxytoluene and captopril. J Tradit Med 2002;19:200–208.
Nakagawa T, Yokozawa T, Terasawa K, Nakanishi K. Therapeutic usefulness of Keishi-bukuryo-gan for diabetic nephropathy. J Pharm Pharmacol 2003;55:219–227.
Nakagawa T, Goto H, Hikiami H, Yokozawa T, Shibahara N, Shimada Y. Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats. J Ethnopharmacol 2007;110:311–317.
Zhao XL, Lin SJ, Zhang LL, Wang JL. Clinical observation on treatment of diabetic nephropathy with Huangqi Danggui Mixture. Chin Tradit Patent Med (Chin) 2007;29:641–644.
Zhang YW, Xie D, Chen YX, Zhang HY, Xia ZX. Protective effect of Gui Qi mixture on the progression of diabetic nephropathy in rats. Exp Clin Endocrinol Diabetes 2006;114:563–568.
Zhang YW, Xie D, Xia B, Zhen RT, Liu IM, Cheng JT. Suppression of transforming growth factor-beta1 gene expression by Danggui Buxue tang, a traditional Chinese herbal preparation, in retarding the progress of renal damage in streptozotocin-induced diabetic rats. Horm Metab Res 2006;38:82–88.
Song XY, Chen Q, Qi XY. Effect of Liuwei Dihuang Pill on erythrocyte aldose reductase activity in early diabetic nephropathy patients. Chin J Integr Tradit Chin Med (Chin) 2004;24:1087–1090.
Wang XM. Liuwei Dihuang Pill for the treatment of early diabetic nephropathy. China Foreign Med (Chin) 2010;33:111–112.
Li Y. Protective effect of long-term use of Liuwei Dihuang Pill for diabetic nephropathy. World Health Dig (Chin) 2008;5:5106.
Liu HR, Tang XY, Dai DZ, Dai Y. Ethanol extracts of Rehmannia complex (Di Huang) containing no Corni fructus improve early diabetic nephropathy by combining suppression on the ET-ROS axis with modulate hypoglycemic effect in rats. J Ethnopharmacol 2008;118:466–472.
Kim CS, Sohn EJ, Kim YS, Jung DH, Jang DS, Lee YM, et al. Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. J Ethnopharmacol 2007;111:240–247.
Kim YS, Lee YM, Kim CS, Sohn EJ, Jang DS, Kim JS. Inhibitory effect of KIOM-79, a new herbal prescription, on AGEs formation and expressions of type IV collagen and RGF-beta1 in STZ-induced diabetic rats. Korean J Pharmacogn 2006;37:103–109.
Jung DH, Kim YS, Kim JS. KIOM-79 prevents S100binduced TGF-beta1 and fibronectin expression in mouse mesangial cells. J Ethnopharmacol 2009;125:374–379.
Zhang QC, Bao XH, Zhang ZZ. Treatment of 31 cases of diabetic nephropathy with Wenpi Decoction. Zhejiang J Integr Tradit Chin (Chin) 2003;13:580–581.
Yokozawa T, Satoh A, Nakagawa T, Yamabe N. Attenuating effects of Wen-Pi-Tang treatment in rats with diabetic nephropathy. Am J Chin Med 2006;34:307–321.
Rhyu DY, Kang KS, Sekiya M, Tanaka T, Park JC, Yokozawa T. Active compounds isolated from traditional Chinese prescription Wen-Pi-Tang protecting against peroxynitrite-induced LLC-PK1 cell damage. Am J Chin Med 2008;36:761–770.
Liu IM, Tzeng TF, Liou SS, Chang CJ. The amelioration of streptozotocin diabetes-induced renal damage by Wu- Ling-San (Hoelen Five Herb Formula), a traditional Chinese prescription. J Ethnopharmacol 2009;124:211–218.
Wang XM. Treatment of diabetic nephropathy with Zhenwu Decoction. World Health Dig (Chin) 2007;4:61–63.
Cai Y, Chen J, Jiang J, Cao W, He L. Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats. J Ethnopharmacol 2010;131:88–94.
Li M, Wang W, Xue J, Gu Y, Lin S. Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol 2011;133:412–419.
Dou LJ, Feng LM, Xu XY. Effects of astragalus membranaceus on urinary endothelin in patients with incipient diabetic nephropathy. Chin J Integr Med 2000;6:263–265.
Zhang YW, Wu CY, Cheng JT. Merit of Astragalus polysaccharide in the improvement of early diabetic nephropathy with an effect on mRNA expressions of NF-kappaB and I kappaB in renal cortex of streptozotocininduced diabetic rats. J Ethnopharmacol 2007;114:387–392.
Al-Qattan K, Thomson M, Ali M. Garlic (Allium sativum) and ginger (Zingiber officinale) attenuate structural nephropathy progression in streptozotocin-induced diabetic rats. Eur J Clin Nutr Metab 2008;3:62–71.
Mariee AD, Abd-Allah GM, El-Yamany MF. Renal oxidative stress and nitric oxide production in streptozotocin-induced diabetic nephropathy in rats: the possible modulatory effects of garlic (Allium sativum L.). Biotechnol Appl Biochem 2009;52:227–232.
Hosseini M, Shafiee SM, Baluchnejadmojarad T. Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats. Pathophysiology 2007;14:109–112.
Li M. Effects of Ginkgo injection on hemorheology and urinary albumin excretion rate in early diabetic nephropathy. Anhui Med Pharm J (Chin) 2010;14:220–221.
Li XS, Zheng WY, Lou SX, Lu XW, Ye SH. Effect of ginkgo leaf extract on vascular endothelial function in patients with early stage diabetic nephropathy. Chin J Integr Med 2009;15:26–29.
Lu Q, Yin XX, Wang JY, Gao YY, Pan YM. Effects of Ginkgo biloba on prevention of development of experimental diabetic nephropathy in rats. Acta Pharmacol Sin 2007;28:818–828.
Ohno T, Takemura G, Murata I, Kagawa T, Akao S, Minatoguchi S, et al. Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice. Life Sci 2005;77:1391–1403.
Yokozawa T, Kim HY, Yamabe N. Amelioration of diabetic nephropathy by dried Rehmanniae Radix (Di Huang) extract. Am J Chin Med 2004;32:829–839.
Williams JA, Choe YS, Noss MJ, Baumgartner CJ, Mustad VA. Extract of Salacia oblonga lowers acute glycemia in patients with type 2 diabetes. Am J Clin Nutr 2007;86:124–130.
He L, Qi Y, Rong X, Jiang J, Yang Q, Yamahara J, et al. The Ayurvedic medicine Salacia oblonga attenuates diabetic renal fibrosis in rats: suppression of angiotensin II/AT1 signaling. Evid Based Complement Altern Med 2009:3–13.
Gondwe M, Kamadyaapa DR, Tufts M, Chuturgoon AA, Musabayane CT. Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark ethanolic extract (SBE) modulates blood glucose, glomerular filtration rate (GFR) and mean arterial blood pressure (MAP) of STZ-induced diabetic rats. Phytomedicine 2008;15:699–709.
0
浏览量
0
Downloads
3
CSCD
关联资源
相关文章
相关作者
相关机构