Drug discovery enters a new era with multi-target intervention strategy

Xiao-ying Tian; Liang Liu

doi:10.1007/s11655-011-0900-2

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Drug discovery enters a new era with multi-target intervention strategy

OriginalPaper | Updated：2021-08-27

- Drug discovery enters a new era with multi-target intervention strategy
- Drug discovery enters a new era with multi-target intervention strategy
- 中国结合医学杂志（英文版） 2012年18卷第7期页码：539-542
- Affiliations：
  
  1. Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University,Hong Kong SAR,China
  2. State Key Laboratory for Quality Research in Chinese Medicines, Macau University of Science and Technology, Taipa, Macau,China
- Author bio：
- Funds：
  
  Supported by Hong Kong Baptist University (RC/08-09/GEN-043)
- DOI：10.1007/s11655-011-0900-2
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-4-11，
Scan for full text
Tian, Xy., Liu, L. Drug discovery enters a new era with multi-target intervention strategy., Chin. J. Integr. Med. 18, 539–542 (2012). https://doi.org/10.1007/s11655-011-0900-2

Xiao-ying Tian, Liang Liu. Drug discovery enters a new era with multi-target intervention strategy[J]. Chinese Journal of Integrative Medicine, 2012,18(7):539-542.
Tian, Xy., Liu, L. Drug discovery enters a new era with multi-target intervention strategy., Chin. J. Integr. Med. 18, 539–542 (2012). https://doi.org/10.1007/s11655-011-0900-2 DOI：

Xiao-ying Tian, Liang Liu. Drug discovery enters a new era with multi-target intervention strategy[J]. Chinese Journal of Integrative Medicine, 2012,18(7):539-542. DOI： 10.1007/s11655-011-0900-2.

摘要

In the past century

as medical research has become increasingly precise

it has become clear that the incidence and progression of many diseases involve multiple factors and pathologies; this is particularly true for the degenerative and metabolic diseases facing industrialized societies. At the same time

it becomes increasingly clear that single-target action drugs cannot effectively treat these diseases. Researchers are looking toward the chemical industry as well as traditional herbal medicines to find multi-target interventions. Thus

a new era in drug discovery has begun. Specifically

three approaches have proven effective in seeking multi-target drugs. These are: (1) designing drugs with multiple components; (2) discovering drugs through the study of synergistic compound-compound interactions in medicinal herbs or among chemical drugs and herbal components; and (3) developing drugs to tackle complex multi-component diseases. The authors conclude that there is an increasing need for multi-component remedies to treat the complex chronic diseases afflicting modern populations. Given this situation and the growing body of evidence that these new approaches are effective

multi-target intervention appears to have great potential for discovering

designing

and developing effective new drugs for today’s diseases.

Abstract

In the past century

as medical research has become increasingly precise

a new era in drug discovery has begun. Specifically

multi-target intervention appears to have great potential for discovering

designing

and developing effective new drugs for today’s diseases.

关键词

multi-target interventioncompound-compound interactionherb-drug interactionsynergymulti-component remedy

Keywords

multi-target interventioncompound-compound interactionherb-drug interactionsynergymulti-component remedy

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