The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage

Lan Yin; Yu-li Pi; Mao-nian Zhang

doi:10.1007/s11655-011-0901-1

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The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage

OriginalPaper | Updated：2021-08-27

- The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage
- The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage
- 中国结合医学杂志（英文版） 2012年18卷第4期页码：299-303
- Affiliations：
  
  1. Department of Ophthalmology, the First Affiliated Hospital of the General Hospital of PLA,Beijing,China
  2. Department of Ophthalmology, the General Hospital of People’s Liberation Army,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0901-1
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-3-30，
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Yin, L., Pi, Yl. & Zhang, Mn. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage., Chin. J. Integr. Med. 18, 299–303 (2012). https://doi.org/10.1007/s11655-011-0901-1

Lan Yin, Yu-li Pi, Mao-nian Zhang. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage[J]. Chinese Journal of Integrative Medicine, 2012,18(4):299-303.
Yin, L., Pi, Yl. & Zhang, Mn. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage., Chin. J. Integr. Med. 18, 299–303 (2012). https://doi.org/10.1007/s11655-011-0901-1 DOI：

Lan Yin, Yu-li Pi, Mao-nian Zhang. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage[J]. Chinese Journal of Integrative Medicine, 2012,18(4):299-303. DOI： 10.1007/s11655-011-0901-1.

摘要

To study the effect of Vaccinium uliginosum L.

(VU) on the electroretinogram (ERG) and retinal pathological changes in rabbits after light-induced damage. Twenty-eight Chinchilla rabbits were randomly divided into four groups: administration beforehand (A)

administration after injury (B)

light injury without administration (C)

and blank (D) groups. After a 4-week administration of VU homogenate at 4.8 g/(kg·d) once a day in group A

ERG in groups A

B and C were recorded according to the standards set by the International Society for Clinical Electrophysiology of Vision (ISCEV). Except for group D

the groups were then exposed to strong light. Just after that

group A stopped receiving VU treatment and group B started to receive it. Then ERGs in all groups were recorded after 1 day

1 week

and 2 weeks. Throughout the whole process groups which were not fed with VU were fed with normal saline. Finally

the tissues and structures of all the groups were observed and the thickness of the outer nuclear layers (ONL) was measured. (1) After 4-week feeding with VU

the latency time of ERG in group A became shorter than those in the other groups and the amplitude increased. After being exposed to strong light

the latency time lengthened and amplitude decreased in all the injury groups

but comparing at each time point

the measured values in group A were better than those in group C. With the accumulation of VU

the ERG in group B improved

and finally

all of the detected values became better than those in group C. (2) Retinae in group D were normal in histology and the layers were in order but those in group C became disarranged. The injuries in groups A and B were minor compared with those in group C. The thickness of the ONL in group C was significantly thinner than in the other groups (P=0.000)

and that in groups A and B was thicker than that in group C

although thinner than in group D. That in group A was thicker than in group B. VU can relieve the injury to rabbit retinae exposed to normal day and night rhythm

alleviate the harm caused by light when used beforehand

and repair the light damage to the retina.

Abstract

To study the effect of Vaccinium uliginosum L.

administration after injury (B)

light injury without administration (C)

and blank (D) groups. After a 4-week administration of VU homogenate at 4.8 g/(kg·d) once a day in group A

ERG in groups A

B and C were recorded according to the standards set by the International Society for Clinical Electrophysiology of Vision (ISCEV). Except for group D

the groups were then exposed to strong light. Just after that

group A stopped receiving VU treatment and group B started to receive it. Then ERGs in all groups were recorded after 1 day

1 week

and 2 weeks. Throughout the whole process groups which were not fed with VU were fed with normal saline. Finally

the tissues and structures of all the groups were observed and the thickness of the outer nuclear layers (ONL) was measured. (1) After 4-week feeding with VU

the latency time of ERG in group A became shorter than those in the other groups and the amplitude increased. After being exposed to strong light

the latency time lengthened and amplitude decreased in all the injury groups

but comparing at each time point

the measured values in group A were better than those in group C. With the accumulation of VU

the ERG in group B improved

and finally

and that in groups A and B was thicker than that in group C

although thinner than in group D. That in group A was thicker than in group B. VU can relieve the injury to rabbit retinae exposed to normal day and night rhythm

alleviate the harm caused by light when used beforehand

and repair the light damage to the retina.

关键词

Vaccinium uliginosum L.light-induced damageelectroretinogramhistology

Keywords

Vaccinium uliginosum L.light-induced damageelectroretinogramhistology

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