Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats

Huan Wang; Wen-juan Zhong; Ming-wei Huang; Xiao-ying Wu; Hui Chen

doi:10.1007/s11655-011-0935-4

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Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats

OriginalPaper | Updated：2021-08-27

- Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats
- Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats
- 中国结合医学杂志（英文版） 2011年17卷第12期页码：917-924
- Affiliations：
  
  Fujian Provincial Cardiovascular Disease Institute, Provincial Clinical College of Fujian Medical University,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the Grants of Fujian Province Health Education Union Scientific, Ministry of Health of the People’s Republic of China (WKJ 2008-2-59)
- DOI：10.1007/s11655-011-0935-4
  中图分类号：
- 纸质出版日期：2011，
  
  网络出版日期：2011-12-3，
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Wang, H., Zhong, Wj., Huang, Mw. et al. Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats., Chin. J. Integr. Med. 17, 917–924 (2011). https://doi.org/10.1007/s11655-011-0935-4

Huan Wang, Wen-juan Zhong, Ming-wei Huang, et al. Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats[J]. Chinese Journal of Integrative Medicine, 2011,17(12):917-924.
Wang, H., Zhong, Wj., Huang, Mw. et al. Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats., Chin. J. Integr. Med. 17, 917–924 (2011). https://doi.org/10.1007/s11655-011-0935-4 DOI：

Huan Wang, Wen-juan Zhong, Ming-wei Huang, et al. Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules (脑心通胶囊) following coronary microembolization induced by homologous microthrombi in rats[J]. Chinese Journal of Integrative Medicine, 2011,17(12):917-924. DOI： 10.1007/s11655-011-0935-4.

摘要

To evaluate the effificacy of dual antiplatelet therapy combined with Naoxintong Capsule (脑心通胶囊

NXTC) in a rat model of coronary microembolization (CME). A total of 95 rats were randomly divided into 6 groups: control

sham-operation

CME model

NXTC

dual antiplatelet (clopidogrel and aspirin) intervention (DA)

and NXTC combined with DA (NDA) groups. The complete data in 69 rats were obtained. The number of CME

myocardial apoptosis rate

bleeding time

clotting time

and adensosine diphosphate (ADP)-induced platelet aggregation were assessed. Compared with the CME group

the number of CME and myocardial apoptosis rates were signifificantly decreased in the NXTC

and NDA groups (P <0.01). Compared with other intervention groups

the number of CME and myocardial apoptosis rates were the least in the NDA group (P <0.01)

and the incidence of surgical bleeding was the highest in the DA group (P <0.01). Compared with the CME group

ADP-induced maximum platelet aggregation rate was significantly inhibited in the NXTC

and NDA groups (P <0.01)

both bleeding time and clotting time were signifificantly increased in the NXTC

and NDA groups (P <0.01)

while the above parameters were the highest in the DA group (P <0.05). The combination therapy of NXTC and DA enhanced the anti-CME effect of either therapy alone and reduced the risk of the DA therapy-associated bleeding

demonstrating an improved benefifit/ risk ratio in the rat model of CME.

Abstract

To evaluate the effificacy of dual antiplatelet therapy combined with Naoxintong Capsule (脑心通胶囊

NXTC) in a rat model of coronary microembolization (CME). A total of 95 rats were randomly divided into 6 groups: control

sham-operation

CME model

NXTC

dual antiplatelet (clopidogrel and aspirin) intervention (DA)

and NXTC combined with DA (NDA) groups. The complete data in 69 rats were obtained. The number of CME

myocardial apoptosis rate

bleeding time

clotting time

and adensosine diphosphate (ADP)-induced platelet aggregation were assessed. Compared with the CME group

the number of CME and myocardial apoptosis rates were signifificantly decreased in the NXTC

and NDA groups (P <0.01). Compared with other intervention groups

the number of CME and myocardial apoptosis rates were the least in the NDA group (P <0.01)

and the incidence of surgical bleeding was the highest in the DA group (P <0.01). Compared with the CME group

ADP-induced maximum platelet aggregation rate was significantly inhibited in the NXTC

and NDA groups (P <0.01)

both bleeding time and clotting time were signifificantly increased in the NXTC

and NDA groups (P <0.01)

demonstrating an improved benefifit/ risk ratio in the rat model of CME.

关键词

Naoxintong Capsuledual antiplatelet therapycoronary microembolizationChinese Medicine

Keywords

Naoxintong Capsuledual antiplatelet therapycoronary microembolizationChinese Medicine

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