Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer

Zong-yang Yu; Zhi-zhen Liu; Xue-nong Ouyang; Jian Du; Xi-hu Dai; Xi Chen; Zhong-quan Zhao; Wen-wu Wang; Jie Li

doi:10.1007/s11655-012-0994-1

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Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer

OriginalPaper | Updated：2021-08-27

- Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer
- Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer
- 中国结合医学杂志（英文版） 2012年18卷第2期页码：106-111
- Affiliations：
  
  1. Department of Oncology, Fuzhou General Hospital, Nanjing Military Command,Fuzhou,China
  2. Fujian Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the Key Subject of People’s Liberation Army Eleventh-Five-Year Traditional Chinese Medicine Clinical Research Program (No. 2006051002)
- DOI：10.1007/s11655-012-0994-1
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-2-5，
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Yu, Zy., Liu, Zz., Ouyang, Xn. et al. Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer., Chin. J. Integr. Med. 18, 106–111 (2012). https://doi.org/10.1007/s11655-012-0994-1

Zong-yang Yu, Zhi-zhen Liu, Xue-nong Ouyang, et al. Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer[J]. Chinese Journal of Integrative Medicine, 2012,18(2):106-111.
Yu, Zy., Liu, Zz., Ouyang, Xn. et al. Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer., Chin. J. Integr. Med. 18, 106–111 (2012). https://doi.org/10.1007/s11655-012-0994-1 DOI：

Zong-yang Yu, Zhi-zhen Liu, Xue-nong Ouyang, et al. Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer[J]. Chinese Journal of Integrative Medicine, 2012,18(2):106-111. DOI： 10.1007/s11655-012-0994-1.

摘要

To examine the effect of a Chinese medicinal herbal formula (Feitai Capsule

肺泰胶囊) on the quality of life (QOL) and progression-free survival (PFS) of patients with unresectable non-small cell lung cancer (NSCLC). Sixty-two patients were randomly divided into the treatment group (31 cases) and the control group (31 cases). For the treatment group

4 capsules (1.2 g/capsule) of Feitai Capsule were administered 3 times a day after meals for 3 weeks; then no drug was administered for 1 week. This schedule was continued for at least 3 more cycles (12 weeks totally). If there were no obvious toxic reactions

the treatment was extended. The patients were evaluated at least once every 8 weeks until progressive disease (PD). For the control group

the regular follow-up and evaluation were performed at least once every 8 weeks until PD. Clinical symptoms

objective response

physical constitution and energy

QOL

and PFS were evaluated regularly. Analysis of variance (ANOVA)

a non-parametric test

and analysis of covariance were used to compare clinical features

amelioration of clinical symptoms

physical constitution and energy

and QOL. Kaplan-Meier analysis was used to compare the two-group PFS. Sixty patients finished the final evaluation

with 30 patients in each group. Baseline characters between groups were not significantly different (P>0.05). The control group had a 36.7% improvement in clinical symptoms

while the treatment group had a 73.3% improvement. This difference was statistically significant (Z= −2.632

P=0.008). The control group had a 26.7% improvement in the Karnofsky performance status (KPS)

while the treatment group had a 53.4% improvement. This was also significantly different (Z=−2.182

P=0.029). A comparative analysis indicated a positive correlation (r=0.917

P<0.001). Compared with the control group

QOL in the treatment group was significantly improved

except in the social/family condition and doctor-patient relationship indicators. The PFS of the treatment group and control group were 6.23 months and 4.67 months

respectively (P=0.048). Feitai Capsule

a Chinese medicinal herbal treatment could improve the QOL and extend the PFS of the unresectable NSCLC patients.

Abstract

To examine the effect of a Chinese medicinal herbal formula (Feitai Capsule

the treatment was extended. The patients were evaluated at least once every 8 weeks until progressive disease (PD). For the control group

the regular follow-up and evaluation were performed at least once every 8 weeks until PD. Clinical symptoms

objective response

physical constitution and energy

QOL

and PFS were evaluated regularly. Analysis of variance (ANOVA)

a non-parametric test

and analysis of covariance were used to compare clinical features

amelioration of clinical symptoms

physical constitution and energy

and QOL. Kaplan-Meier analysis was used to compare the two-group PFS. Sixty patients finished the final evaluation

with 30 patients in each group. Baseline characters between groups were not significantly different (P>0.05). The control group had a 36.7% improvement in clinical symptoms

while the treatment group had a 73.3% improvement. This difference was statistically significant (Z= −2.632

P=0.008). The control group had a 26.7% improvement in the Karnofsky performance status (KPS)

while the treatment group had a 53.4% improvement. This was also significantly different (Z=−2.182

P=0.029). A comparative analysis indicated a positive correlation (r=0.917

P<0.001). Compared with the control group

QOL in the treatment group was significantly improved

except in the social/family condition and doctor-patient relationship indicators. The PFS of the treatment group and control group were 6.23 months and 4.67 months

respectively (P=0.048). Feitai Capsule

a Chinese medicinal herbal treatment could improve the QOL and extend the PFS of the unresectable NSCLC patients.

关键词

non-small cell lung cancerChinese MedicineFeitai Capsulemaintenance treatmentquality of lifeprogression-free survival

Keywords

non-small cell lung cancerChinese MedicineFeitai Capsulemaintenance treatmentquality of lifeprogression-free survival

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