FOLLOWUS
Atherosclerosis, vascular aging and therapeutic strategies
Atherosclerosis, vascular aging and therapeutic strategies
- 中国结合医学杂志（英文版） 2012年18卷第2期 页码：83-87
- Affiliations：
Cardiovascular Disease Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
DOI：10.1007/s11655-012-0996-z
中图分类号：纸质出版日期：2012，
网络出版日期：2012-2-5，
Scan for full text
Liu, Y., Chen, Kj. Atherosclerosis, vascular aging and therapeutic strategies., Chin. J. Integr. Med. 18, 83–87 (2012). https://doi.org/10.1007/s11655-012-0996-z
Yue Liu, Ke-ji Chen. Atherosclerosis, vascular aging and therapeutic strategies[J]. Chinese Journal of Integrative Medicine, 2012,18(2):83-87.
Liu, Y., Chen, Kj. Atherosclerosis, vascular aging and therapeutic strategies., Chin. J. Integr. Med. 18, 83–87 (2012). https://doi.org/10.1007/s11655-012-0996-z DOI：
Yue Liu, Ke-ji Chen. Atherosclerosis, vascular aging and therapeutic strategies[J]. Chinese Journal of Integrative Medicine, 2012,18(2):83-87. DOI： 10.1007/s11655-012-0996-z.
摘要
With the arrival of the era of global population aging
we strive for healthy aging and a healthy senior life rather than simple prolongation of the physical age. For the past 50 years
cardiovascular diseases (CVD) have been the most common cause of death among the elderly people globally. In China
there has been an exponential increase in the incidence of heart disease and stroke in the elderly population. Atherosclerosis is the pathological change in the coronary artery disease
stroke
and peripheral vascular disease. Despite the signifificant benefifit demonstrated
control of classic risk factors alone
such as lifestyle change or drug therapy
was shown to have limitations in reducing the incidence of cardiovascular events. Vascular aging has been shown to be an important independent predictor of CVD events. Interventions targeting vascular aging have emerged as a new paradigm in conjunction with control of risk factors for the prevention of CVD. Vascular aging and atherosclerosis are two distinct pathological changes and diffificult to distinguish clinically. Recent research with Chinese medicine (CM) has shown encouraging observations
linking the clinical benefit of delaying vascular aging and treating atherosclerosis. These results demonstrate great potential of CM in the prevention and treatment of CVD.
Abstract
With the arrival of the era of global population aging
we strive for healthy aging and a healthy senior life rather than simple prolongation of the physical age. For the past 50 years
cardiovascular diseases (CVD) have been the most common cause of death among the elderly people globally. In China
there has been an exponential increase in the incidence of heart disease and stroke in the elderly population. Atherosclerosis is the pathological change in the coronary artery disease
stroke
and peripheral vascular disease. Despite the signifificant benefifit demonstrated
control of classic risk factors alone
such as lifestyle change or drug therapy
was shown to have limitations in reducing the incidence of cardiovascular events. Vascular aging has been shown to be an important independent predictor of CVD events. Interventions targeting vascular aging have emerged as a new paradigm in conjunction with control of risk factors for the prevention of CVD. Vascular aging and atherosclerosis are two distinct pathological changes and diffificult to distinguish clinically. Recent research with Chinese medicine (CM) has shown encouraging observations
linking the clinical benefit of delaying vascular aging and treating atherosclerosis. These results demonstrate great potential of CM in the prevention and treatment of CVD.
关键词
atherosclerosisvascular agingChinese Medicinelifespan
Keywords
atherosclerosisvascular agingChinese Medicinelifespan
references
National Center for Cardiovascular Diseases of China. Report on cardiovascular diseases in China (2010). Beijing: Encyclopedia of China Publishing House; 2011:1.
Hua W, Zhang LF, Wu YF, Liu XQ, Guo DS, Zhou HL, et al. Incidence of sudden cardiac death in China: analysis of 4 regional populations. J Am Coll Cardiol 2009;54:1110–1118.
Yang WY, Lu JM, Weng JP, Jia WP, Ji LN, Xiao JZ, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090–1101.
Fuster V. Atherosclerosis, thrombosis, and vascular biology. In: Goldman L, Ausiello D, eds. Cecil medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007: chap 69:383–385.
Kannel WB, Dawber TR, Kagana, Revotskie N, Stokes J 3rd. Factors of risk in the development of coronary heart disease—six-year follow-up experience. The Framingham Study. Ann Intern Med 1961;55:33–50.
O’Donnell CJ, Elosua R. Cardiovascular risk factors. Insights from Framingham Heart Study. Rev Esp Cardiol 2008;61:299–310.
Laatikainen T, Critchley J, Vartiainen E, Salomaa V, Ketonen M, Capewell S. Explaining the decline in coronary heart disease mortality in Finland between 1982 and 1997. Am J Epidemiol 2005;162:764–773.
Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980–2000. N Engl J Med 2007;356:2388–2398.
Spence JD, Hackam DG. Treating arteries instead of risk factors: a paradigm change in management of atherosclerosis. Stroke 2010;41:1193–1199.
Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 2008;358:580–591.
Spence JD. Point: uses of carotid plaque measurement as a predictor of cardiovascular events. Prev Cardiol 2005;8:118–121.
Spence JD, Eliasziw M, DiCicco M, Hackam DG, Galil R, Lohmann T. Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy. Stroke 2002;33:2916–2922.
Spence JD. Technology insight: ultrasound measurement of carotid plaque—patient management, genetic research, and therapy evaluation. Nat Clin Pract Neurol 2006;2:611–619.
Sawabe M. Vascularaging: from molecular mechanism to clinical significance. Geriatr Gerontol Int 2010;10(Suppl):S213–S220.
Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, et al. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium dependent dilation and upregulation of nuclear factorkappaB. Circ Res 2007;100:1659–1666.
Csiszar A, Wang M, Lakatta EG, Ungvari ZI. Inflammation and endothelial dysfunction during aging: role of NF-kappa B. J Appl Physiol 2008;105:1333–1341.
Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000;908:244–254.
Wang M, Zhang J, Jiang LQ, Spinetti G, Pintus G, Monticone R, et al. Proinflammatory profile within the grossly normal aged human aortic wall. Hypertension 2007;50:219–227.
Jiang L, Wang M, Zhang J, Monticone RE, Telljohann R, Spinetti G, et al. Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells. PLoS One 2008;3:e2231.
Rivard A, Fabre JE, Silver M, Chen D, Murohara T, Kearney M, et al. Age-dependent impairment of angiogenesis. Circulation 1999; 99:111–120.
Weinsaft JW, Edelberg JM. Aging-associated changes in vascular activity: a potential link to geriatric cardiovascular disease. Am J Geriatr Cardiol 2001;10:348–354.
Erusalimsky JD. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 2009;106:326–332.
Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, et al. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation 2007;116:2818–2829.
Ungvari Z, Kaley G, de Cabo R, Sonntag WE, Csiszar A. Mechanisms of vascular aging: new perspectives. J Gerontol A Biol Sci Med Sci 2010;65:1028–1041.
Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM. Effects of aging and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J Physiol 2009;587:3885–3897.
Taddei S, Galetta F, Virdis A, Ghiadoni L, Salvetti G, Franzoni F, et al. Physical activity prevents age related impairment in nitric oxide availability in elderly athletes. Circulation 2000;101:2896–2901.
Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R. Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res 2008;102:519–528.
Okazaki S, Yokoyama T, Miyauchi K, Shimada K, Kurata T, Sato H, et al. Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study. Circulation 2004;110:1061–1068.
Csiszar A, Ungvari Z, Edwards JG, Kaminski P, Wolin MS, Koller A, et al. Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res 2002;90:1159–1166.
Bruunsgaard H, Skinhoj P, Pedersen AN, Schroll M, Pedersen BK. Ageing, tumour necrosis factor-alpha (TNF-alpha) and atherosclerosis. Clin Exp Immunol 2000;121:255–260.
Sonntag WE, Ramsey M, Carter CS. Growth hormone and insulinlike growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res Rev 2005;4:195–212.
Lei Y, Yang J, Zhao H, Du XJ, Liu JG, Chen KJ. Experimental study on extracts from Ginseng, Notoginseng and Chuanxiong for delaying vascular aging in senescent Mice. Chin J Integr Tradit West Med (Chin) 2010;30:946–951.
Yang J, Lei Y, Fang SP, Cui W, Chen KJ. Study on acting mechanism of extracts from Ginseng, Notoginseng and Chuanxiong for delaying the aging of endothelial cells induced by angiotensin II. Chin J Integr Tradit West Med (Chin) 2009;29:524–528.
Lu XY, Shi DZ, Xu H, Chen KJ, Lv SZ. Clinical study on effect of Xiongshao Capsule on restenosis after percutaneous coronary intervention. Chin J Integr Tradit West Med (Chin) 2006;26:13–17.
Chen KJ, Shi DZ, Xu H, Lu SZ, Li TC, Ke YN, et al. XS0601 reduces the incidence of restenosis: a prospective study of 335 patients undergoing percutaneous coronary intervention in China. Chin Med J 2006;119:6–13.
Zhang DW, Zhang L, Liu JG, Wang CL, Shi DZ, Chen KJ. Effects of Xiongshao Capsule combined with ischemic postconditioning on monocyte chemoattractant protein-1 and tumor necrosis factor-α in rat myocardium with ischemic reperfusion injury. Chin J Integr Tradit West Med (Chin) 2010;30:1279–1283.
Huang Y, Yin HJ, Ma XJ, Wang JS, Liu Q, Wu CF, et al. Correlation between FcγRIIIA and aortic atherosclerotic plaque destabilization in apoE knockout mice and intervention effects of effective components of Chuanxiong rhizome and red peony root. Chin J Integr Med 2011;17:355–360.
David E. Bloom. 7 billion and counting. Science 2011;333: 562–569.
Boos CJ, Goon PK, Lip GY. Endothelial progenitor cells in the vascular pathophysiology of hypertension: arterial stiffness, ageing and more. J Hum Hypertens 2006; 20:475–477.
0
浏览量
147
Downloads
16
CSCD
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 邮编：100091
- 联系电话：010-62886827, 62877592 传真：010-62874291
- 技术支持由北京北大方正电子有限公司提供 京ICP备05067934号-1
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies
