Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review

Nuo Li; Yue-qing Li; Hong-yan Li; Wei Guo; Yan-ping Bai

doi:10.1007/s11655-012-1004-3

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Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review

ReviewPaper | Updated：2021-08-27

- Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review
- Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review
- 中国结合医学杂志（英文版） 2012年18卷第3期页码：222-229
- Affiliations：
  
  1. The First Hospital of Beijing University of Chinese Medicine,Beijing,China
  2. Department of Dermatology, China-Japan Friendship Hospital, Beijng,China
  3. Janssen Pharmaceutical Ltd., Beijing,Xi’an,China
- Author bio：
- Funds：
  
  Supported by the Eleventh Five-Year Program, Ministry of Science and Technology of China (No. 2008BAI53B044)
- DOI：10.1007/s11655-012-1004-3
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-4-2，
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Li, N., Li, Yq., Li, Hy. et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review., Chin. J. Integr. Med. 18, 222–229 (2012). https://doi.org/10.1007/s11655-012-1004-3

Nuo Li, Yue-qing Li, Hong-yan Li, et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review[J]. Chinese Journal of Integrative Medicine, 2012,18(3):222-229.
Li, N., Li, Yq., Li, Hy. et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review., Chin. J. Integr. Med. 18, 222–229 (2012). https://doi.org/10.1007/s11655-012-1004-3 DOI：

Nuo Li, Yue-qing Li, Hong-yan Li, et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review[J]. Chinese Journal of Integrative Medicine, 2012,18(3):222-229. DOI： 10.1007/s11655-012-1004-3.

摘要

To assess the efficacy and safety of external application of Chinese herbal drugs (ex-CHD) in the treatment of psoriasis. Literature regarding randomized clinical trials (RCTs) of psoriasis treatments with ex-CHD

either alone or combined with Western medicine (WM) or physiotherapy

controlled by untreated

placebo or WM treatment were found in electronic databases

including PubMed/MEDLINE

EMBASE

Cochrane Library

Cochrane Central Register of Controlled Trials

China Biology Medicine Disc (CBM)

Chinese National Knowledge Infrastructure (CNKI)

Wanfang database and VIP database from their inception through July 2011. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. A total of 10 randomized trials (involving 1

435 patients) were included. Because both test and control drugs used in the RCTs were different from each other

the effects can only be described singly and calculated. Regarding the total effective rate for the treatment of psoriasis

ex-CHD in combination with ultraviolet radiation b (UVB) or narrow band ultraviolet radiation b (NB-UVB)

which was reported in 6 trials

was superior to UVB alone. One study reported that ex-CHD and externally applied WM had equivalent effects. In another study

ex-CHD showed better results than placebo. However

another two comparisons of ex-CHD and WM (all in combining with oral WM) showed uncertain outcomes. Nine trials reported adverse reactions. Of these

7 RCTs included statistical analysis. The results showed that the side-effects that occurred in ex-CHD combined with UVB were less severe than those caused by UVB alone

but the incidence was roughly the same as WM. The evidence supporting the efficacy of ex-CHD with respect to treating psoriasis is quite limited and must be strengthened by high-quality studies.

Abstract

either alone or combined with Western medicine (WM) or physiotherapy

controlled by untreated

placebo or WM treatment were found in electronic databases

including PubMed/MEDLINE

EMBASE

Cochrane Library

Cochrane Central Register of Controlled Trials

China Biology Medicine Disc (CBM)

Chinese National Knowledge Infrastructure (CNKI)

Wanfang database and VIP database from their inception through July 2011. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. A total of 10 randomized trials (involving 1

435 patients) were included. Because both test and control drugs used in the RCTs were different from each other

the effects can only be described singly and calculated. Regarding the total effective rate for the treatment of psoriasis

ex-CHD in combination with ultraviolet radiation b (UVB) or narrow band ultraviolet radiation b (NB-UVB)

which was reported in 6 trials

was superior to UVB alone. One study reported that ex-CHD and externally applied WM had equivalent effects. In another study

ex-CHD showed better results than placebo. However

another two comparisons of ex-CHD and WM (all in combining with oral WM) showed uncertain outcomes. Nine trials reported adverse reactions. Of these

7 RCTs included statistical analysis. The results showed that the side-effects that occurred in ex-CHD combined with UVB were less severe than those caused by UVB alone

but the incidence was roughly the same as WM. The evidence supporting the efficacy of ex-CHD with respect to treating psoriasis is quite limited and must be strengthened by high-quality studies.

关键词

psoriasisChinese Medicineexternal treatmentrandomized controlled trialsystematic review

Keywords

psoriasisChinese Medicineexternal treatmentrandomized controlled trialsystematic review

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