Pinching spine: A potential treatment for depression

Li-hua Jiang; Ling-ling Wang; Ming-yan Wang; Hao-xin Wu; Yi-jie Zou; Xiao-lin Yuan; Mei-juan Chen

doi:10.1007/s11655-012-1028-8

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Pinching spine: A potential treatment for depression

OriginalPaper | Updated：2021-08-27

- Pinching spine: A potential treatment for depression
- Pinching spine: A potential treatment for depression
- 中国结合医学杂志（英文版） 2014年20卷第4期页码：272-279
- Affiliations：
  
  1. Cultivating Candidate of the State Key Laboratory of Integrated Acupuncture and Medication, Nanjing University of Chinese Medicine,Nanjing,China
  2. The Second Clinical College of Nanjing University of Chinese Medicine,Nanjing,China
  3. Basic Medical College of Nanjing University of Chinese Medicine,Nanjing,China
  4. Jiangsu Hospital of Chinese Medicine,Nanjing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1028-8
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2012-3-21，
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Jiang, Lh., Wang, Ll., Wang, My. et al. Pinching spine: A potential treatment for depression., Chin. J. Integr. Med. 20, 272–279 (2014). https://doi.org/10.1007/s11655-012-1028-8

Li-hua Jiang, Ling-ling Wang, Ming-yan Wang, et al. Pinching spine: A potential treatment for depression[J]. Chinese Journal of Integrative Medicine, 2014,20(4):272-279.
Jiang, Lh., Wang, Ll., Wang, My. et al. Pinching spine: A potential treatment for depression., Chin. J. Integr. Med. 20, 272–279 (2014). https://doi.org/10.1007/s11655-012-1028-8 DOI：

Li-hua Jiang, Ling-ling Wang, Ming-yan Wang, et al. Pinching spine: A potential treatment for depression[J]. Chinese Journal of Integrative Medicine, 2014,20(4):272-279. DOI： 10.1007/s11655-012-1028-8.

摘要

To investigate whether pinching spine (PS

i.e. 捏脊

a traditional Chinese manipulative therapy) is beneficial to ameliorating the depressive state (including behavioral deficit

retardative weight gain and decreased sucrose consumption) in a rat model of depression induced by chronic unpredictable stress (CUS) and to explore the candidate mechanism of action. PS was performed on rats’ spine once daily for 1 week after exposure to CUS. The open-field test

body weight measuring

and sucrose intake test were applied on different dates: before stress (d0)

at the end of stress (d21) and after PS treatment (d28)

respectively. Then the rats’ hippocampuses were performed genome-wide microarray analysis

and the expression levels of several genes were evaluated by real-time polymerase chain reaction (PCR). Exposure to CUS resulted in decreases of behavioral activity and sucrose consumption

which were reversed significantly after PS treatment. The expression of several genes relevant to energy metabolism

anti-oxidation

and olfactory receptor

etc.

were down-regulated

while the expression of those relevant to hemostasis

immunity-inflammation

and restriction of activities and ingestion

etc.

were up-regulated in hippocampuses of rats exposed to CUS. PS treatment significantly inverted these changes. Furthermore

increase or decrease in gene expression evaluated by realtime PCR was concordant with up-regulated or down-regulated expression evaluated by microarray analysis. PS showed a potential antidepressant-like effect

of which the action mechanism might be due to gene expression regulation in hippocampus.

Abstract

To investigate whether pinching spine (PS

i.e. 捏脊

a traditional Chinese manipulative therapy) is beneficial to ameliorating the depressive state (including behavioral deficit

body weight measuring

and sucrose intake test were applied on different dates: before stress (d0)

at the end of stress (d21) and after PS treatment (d28)

respectively. Then the rats’ hippocampuses were performed genome-wide microarray analysis

and the expression levels of several genes were evaluated by real-time polymerase chain reaction (PCR). Exposure to CUS resulted in decreases of behavioral activity and sucrose consumption

which were reversed significantly after PS treatment. The expression of several genes relevant to energy metabolism

anti-oxidation

and olfactory receptor

etc.

were down-regulated

while the expression of those relevant to hemostasis

immunity-inflammation

and restriction of activities and ingestion

etc.

were up-regulated in hippocampuses of rats exposed to CUS. PS treatment significantly inverted these changes. Furthermore

of which the action mechanism might be due to gene expression regulation in hippocampus.

关键词

pinching spinedepressionchronic unpredictable stress

Keywords

pinching spinedepressionchronic unpredictable stress

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