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Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task
Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task
- 中国结合医学杂志（英文版） 2015年21卷第7期 页码：493-499
- Affiliations：
1. Department of Cardiovascular & Neurologic Diseases (Stroke Center), College of Oriental Medicine, Kyung Hee University,Seoul,Korea
2. Department of Radiology, College of Medicine, Kyung Hee University,Seoul,Korea
- Author bio：
- Funds：
DOI：10.1007/s11655-012-1031-0
中图分类号：纸质出版日期：2015，
网络出版日期：2012-3-21，
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Jung, WS., Ryu, JM., Kim, YJ. et al. Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task., Chin. J. Integr. Med. 21, 493–499 (2015). https://doi.org/10.1007/s11655-012-1031-0
Woo-Sang Jung, Jong-Man Ryu, Young-Jee Kim, et al. Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task[J]. Chinese Journal of Integrative Medicine, 2015,21(7):493-499.
Jung, WS., Ryu, JM., Kim, YJ. et al. Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task., Chin. J. Integr. Med. 21, 493–499 (2015). https://doi.org/10.1007/s11655-012-1031-0 DOI：
Woo-Sang Jung, Jong-Man Ryu, Young-Jee Kim, et al. Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task[J]. Chinese Journal of Integrative Medicine, 2015,21(7):493-499. DOI： 10.1007/s11655-012-1031-0.
摘要
To evaluate the effect of Uhwang Chungsim Won [UC
Niuhuang Qingxin Pill (牛黄清心丸)] on the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to a motor stimulation task using a hand grasping paradigm. Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. With the administration of UC
BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen
right and left medial frontal gyrus
right parahippocampal gyrus
right and left sublobar insula
right and left posterior cingulate
left precuneus
and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus
right cerebellar culmen
left superior temporal gyrus
right and left middle frontal gyrus
and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate
while there was no increased response to the right hand motor task after UC administration. UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex
but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.
Abstract
To evaluate the effect of Uhwang Chungsim Won [UC
Niuhuang Qingxin Pill (牛黄清心丸)] on the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal response to a motor stimulation task using a hand grasping paradigm. Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. With the administration of UC
BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen
right and left medial frontal gyrus
right parahippocampal gyrus
right and left sublobar insula
right and left posterior cingulate
left precuneus
and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus
right cerebellar culmen
left superior temporal gyrus
right and left middle frontal gyrus
and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate
while there was no increased response to the right hand motor task after UC administration. UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex
but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.
关键词
Uhwang Chungsim WonNiuhuang Qingxin Pillpharmacological fMRICerebral Blood Flow
Keywords
Uhwang Chungsim WonNiuhuang Qingxin Pillpharmacological fMRICerebral Blood Flow
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