FOLLOWUS
1. Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine,Beijing,China
纸质出版日期:2012,
网络出版日期:2012-3-30,
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Cao, W., Guo, Xw., Zheng, Hz. et al. Current progress of research on pharmacologic actions of salvianolic acid B., Chin. J. Integr. Med. 18, 316–320 (2012). https://doi.org/10.1007/s11655-012-1052-8
Wei Cao, Xiao-wen Guo, Hu-zhan Zheng, et al. Current progress of research on pharmacologic actions of salvianolic acid B[J]. Chinese Journal of Integrative Medicine, 2012,18(4):316-320.
Cao, W., Guo, Xw., Zheng, Hz. et al. Current progress of research on pharmacologic actions of salvianolic acid B., Chin. J. Integr. Med. 18, 316–320 (2012). https://doi.org/10.1007/s11655-012-1052-8 DOI:
Wei Cao, Xiao-wen Guo, Hu-zhan Zheng, et al. Current progress of research on pharmacologic actions of salvianolic acid B[J]. Chinese Journal of Integrative Medicine, 2012,18(4):316-320. DOI: 10.1007/s11655-012-1052-8.
As one of the main water-soluble composites of Radix Salviae
salvianolic acid B is a phenolic acid ingredient of the Chinese drug
which is rich content in the herb and has strong pharmaceutical activity. It is used to treat cardiocerebral vascular diseases
antagonize hepatic/renal fibrosis
prevent cancer
and promote stem cell proliferation and differentiation. In the researches of its acting mechanisms
rather deepened studies have been carried out for its application on cardiocerebral vascular diseases
but that for others are rather fewer.
As one of the main water-soluble composites of Radix Salviae
salvianolic acid B is a phenolic acid ingredient of the Chinese drug
which is rich content in the herb and has strong pharmaceutical activity. It is used to treat cardiocerebral vascular diseases
antagonize hepatic/renal fibrosis
prevent cancer
and promote stem cell proliferation and differentiation. In the researches of its acting mechanisms
rather deepened studies have been carried out for its application on cardiocerebral vascular diseases
but that for others are rather fewer.
salvianolic acidpharmacological actionreview
salvianolic acidpharmacological actionreview
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Xie LX, Lu JH, Liu HL, Li M. Effect of LSS-stimulated salvianolic acid B on the expression of ICAM-1 of human aortic endothelial cells. Eval Analysis Drug-use Hosp China (Chin) 2010;10:443–445.
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Meng QN, Li GB, Geng XL, Guo MJ, Fan YC. Study on effect of salvianolic acid B on apoptosis of myocardial cells after acute myocardial infarction in rats. J Tianjin Univ Tradit Chin Med (Chin) 2010;29:80–83.
Fan YC, Zhao GF, Zhang WZ. Influence of salvianolic acid B on pathomorphology in myocardial infarction rats. J Tianjin Univ Tradit Chin Med (Chin) 2004;23:12–14.
Fan YC, Hua SY, Guo MJ, Xu XM. Angiogenic effect of bone mesenchyma stem cells transplantation intervened by Sal B on acute myocardial infarcts in rats infarction in rats. J Tianjin Univ Tradit Chin Med (Chin) 2007;26:133–136.
He HB, Yang XZ, Shi MQ, Zeng XW, Wu LM, Li LD. Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats. Parmocol Rep 2008;60:369–381.
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Zhao GF, Zhang HX. Protective effects of salvianolic acid B on myocardial ischemia-reperfusion injury of rats. J Liaoning Coll Tradit Chin Med (Chin) 2004;6:55–56.
Xu JP, Sun LS, Wu HY, Yang XM. Protective effects of savianolic acid B on myocard-ial ischemia/reperfusion in rats. Chin Pharm J (Chin) 2003;38:595–597.
Zhang L, Yuan DP, Xu L, Jiang BP, Fang TH. Protective mechanism of salvianolic acid B on myocardial ischemia-reperfusion injury of rats. Tradit Chin Drug Res Clin Pharmacol (Chin) 2008;19:467–468.
Yang FG, Chen ZY, Lan ZX, Guo YL, Liu GX, Dong GX. Inhibitory effects of salvian-olic acid B on myocardial cellular nuclear transfer of NF-κB p6 and the expression of TNF-α during ischemia-reperfusion in rabbits hearts in vivo. China J Modern Med (Chin) 2009;1:672–674.
Wang Y, Jiang YF, Huang QF, Cui W, Cai DY, Wang XM. Effects of salvianolic acid B on neurons during oxygen/glucose deprivation and reintroduction. Chin J Pathophysiol (Chin) 2009;25:275–279.
Jiang YF, Wang QH, Liu ZQ, Wang Q, Cai DY, Liu SJ, et al. Effects of salvianolic acid B on cerebral energy charge and activity of ATPase in mice with cerebral ischemia. Chin J Chin Materia Med (Chin) 2007;32:1903–1906.
Wang QH, Jiang YF, Wang Y, Wang WR, Zhang YZ, Liu SJ, et al. Influence of salvianolic acid B on energy metabolism of cerebral ischemia in mice with hypotension. J Beijing Univ Tradit Chin Med (Chin) 2006;29:820–823.
Jin HM, Zhao CM, Zhao X, Gan P, Luo YE, Liu B. Influence of salvianolic acid B on expression of Bcl-2 and Bax proteins in rats with focal cerebra ischemia reperfusion. Chin Arch Tradit Chin Med (Chin) 2008;26:1475–1477.
Liu CL, Xie LX, Li M, Durairajan SSK, Goto S, Huang JD. salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. PLoS ONE 2007;2:e1321.
Zeng G, Tang T, Wu HJ, You WH, Luo JK, Lin Y, et al. Salvianolic acid B protects SH-SY5Y neuroblastoma cells from 1-methyl-4-phenylpyridinium-induced apoptosis. Biol Pharm Bull 2010;33:1337–1342.
Zhao X, Fan YC, Du Y. Influence of salvianolic acid B on serum SOD activities and MDA concentrations in rats with focal cerebral ischemia-reperfusion. Tianjin J Tradit Chin Med (Chin) 2008;25:63–65.
Lu MQ, Pan CW, Li J, Chen YP. Effect of salvianolic acid B on levels of TGF-β1, MMP-2 and TIM P-2 in rats with Iiver fibrosis. World Chin J Digestol (Chin) 2007;15:3847–3850.
Wang LN, Tao YY, Li S, Chen GF, Liu CH. Effects of salvianolic acid B on lipid peroxidation and metalloproteinase-2 activity in fibrotic liver in rat. China J Chin Materia Med (Chin) 2010;35:71–73.
Tao YY, Wang XL, Liu CH. Salvianolic acid B Effects on TGFβ1/ERK signaling transduction in NIH/3T3 fibroblast. J Capital Med Univ (Chin) 2007;28:192–195.
Cheng Y, Ping J, Liu C, Tan YZ, Chen GF. Study on effects of extracts from Salvia Miltiorrhiza and Curcuma Longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat’s hepatic stellate cells. Chin J Integr Med 2006;12:207–211.
Wang XL, Liu P, Hu XD, Ying XP, Li BQ. Gene expression profile analysis of salvianolic acid B in inhibiting fornation of CCl4-induced rat liver fibrosis. Acta Unlvers Tradit Med Sin Pharmcol Shanghai (Chin) 2007;21(2):50–53.
Gan P, Nie GL, Li AS. Protection effect of salvianolic acids B against liver injury in rats with passive cigarette smoking. J Tianjin Univ Tradit Chin Med (Chin) 2009;28:130–132.
Wang QL, Tao YY, Yuan JL, Shen L, Liu CH. Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-β1 signal transduction pathway in vivo and in vitro. BMC Cell Biol 2010;11:1471–2121.
Hu LY, He LQ, Wang YM, Ying RT. Effects of salvianolic acid B on chronic aristolochic acid induced nephropathy in rats. Shaanxi J Tradit Chin Med (Chin) 2008;29:116–118.
Wang QL, Yuan JL, Tao YY, Hu YY, Liu CH. Effect of salvianolic acid B on renal interstitial fibrosis rat induced by HgCI2. Pharmacol Clin Chin Materia Med (Chin) 2008;24:12–14.
Wang WW, Zhang JY. Effect of salvianolic acid B on aristolochic acid-Induced TGFβ1 and p38 MAPK in HK-2 cells. Chin J Integr Tradit West Nephrol (Chin) 2010;11:673–676.
Pan RH, Rui GH, Yao G, Wu JN, Wu XC, Yang C. Effect of salvianolic acid B on epithelial-mesenchymal transition in rats with unilateral ureteral obstruction. Chin J Integr Tradit West Nephrol (Chin) 2008;9:779–981.
Yang Y, Zou DR, Zhou ZT. Chemopreventive effect of salvianolic acid B on oral carcinogenesis. J Shanghai Jiaotong Univ (Med Sci, Chin) 2006;26:1122–1126.
Hao Y, Xie T, Korotcov A, Zhou Y, Pang X, Shan L, et al. Salvianolic acid B inhibits growth of head and neck squamous cell carcinoma in vitro and in vivo via cyclooxygenase-2 and apoptotic pathways. Int J Cancer 2009;124:2200–2209.
Zhao Y, Guo YH, Gu XB. Salvianolic acid B, a potential chemopreventive agent for head and neck Squamous cell cancer. J Oncol 2011;2011:534548–534556.
Guo GQ, Li B, Wang YY, Shan AJ, Shen WZ, Yuan L, et al. Salvianolic acid B promote the proliferation, axon outgrowth and differentiation of neural stem cells from fetal rats neocortex. Sci China (Series C: Life Sci, Chin) 2009;39:793–802.
Zou YH, Chen J, Xie LL, Huang HD, Wang X. Effect of salvianolic acid B on cells factor expressing of mesenchymal stem cells. Lab Anim Sci 2009;26:4–16.
Sun LS, Xu XM, Guo MJ, Zha X, Su JL. Expression of cTnT induced by salvianolic acid B in differentiation of bone marrow mesenchymal stem cells into myocardium-like cell. Tianjin J Tradit Chin Med (Chin) 2007;24:318–320.
Xu XM, Guo MJ, Zhao X, Fan YC. Experimental study on differentiation of bone marrow mesenchymal stem cells into myocardial-like cells induced by salvianolic acid B in vitro. Lishizhen Med Materia Med Res (Chin) 2008;19:574–576.
Hua SY, Fan YC, Ma YW, Wang Q. Effect of Sal B on expression of desmin and α-actin mRNA in differentiation process of bone marrow mesenchymal stem cells into cardiomyocytes in rats. Tianjin J Tradit Chin Med (Chin) 2009;26:145–148.
Cao W, Chen K, Wang J. Effects of Salvia miltiorrhiza monomers and Radix Notoginseng monomers on differentiation of stem cells. Chin J Inform Tradit Chin Med (Chin) 2010;17(8):106–108.
Fan HQ, Cui L. Effects of salvianolic acid B on osteoblast in vitro. Chin Pharmacol Bull (Chin) 2008;24:978–979.
Zhang YJ, Wu T, Zhou XJ, Liu LM. Glucocorticoid-induced skin aging and the effects of Salvia miltiorrhiza and salvianolic acid B in vivo. Chin Hosp Pharm J (Chin) 2008;28:1767–1770.
Zheng F, Jiang XJ, Wang YC, Fan YC. Effects of salvianolic acid B on atherosclerotic plaque area and expressions of AGEs/RAGE in ApoE-gene knock-out mice treated with STZ and high fat die. Tianjin Med J (Chin) 2010;38:777–780.
Liang YH, Li P, Huang QF, Zhao JX, Liu X, Dai MK. Salvianolic acid B in vitro inhibited matrix metalloproteinases-1, -2, and -9 activities. J Chin Integr Med (Chin) 2009;7:145–150.
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