Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?

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Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?

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- Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?
- Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?
- 中国结合医学杂志（英文版） 2014年20卷第1期页码：63-67
- Affiliations：
  
  1. Department of Urology, The First Affiliated Hospital of Soochow University, Soochow,China
  2. Department of Oncology, Guang’anmen Hospital of China Academy of Chinese Medical Sciences,Beijing,China
  3. School of Pharmacy, Guangxi Medical University,Nanning,China
  4. Department of Gynecology and Obstetrics, Guangxi Women and Children Hospital,Nanning,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1080-4
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2012-2-27，
Scan for full text
Li, Yl., Li, J., Yan, Cy. et al. Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?., Chin. J. Integr. Med. 20, 63–67 (2014). https://doi.org/10.1007/s11655-012-1080-4

Yun-long Li, Jie Li, Chun-yin Yan, et al. Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?[J]. Chinese Journal of Integrative Medicine, 2014,20(1):63-67.
Li, Yl., Li, J., Yan, Cy. et al. Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?., Chin. J. Integr. Med. 20, 63–67 (2014). https://doi.org/10.1007/s11655-012-1080-4 DOI：

Yun-long Li, Jie Li, Chun-yin Yan, et al. Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?[J]. Chinese Journal of Integrative Medicine, 2014,20(1):63-67. DOI： 10.1007/s11655-012-1080-4.

摘要

Malignant cancer is the leading cause of death in man

exceeding cerebrovascular disease and heart disease. More than half of the total mortality due to malignant cancer is from lung

liver

intestinal and gastric cancer. Chemotherapy is one of the effective treatments for cancer. However

the great majority of Western anticancer medicines have considerable side effects. Herbal medicines offer many more advantages than synthesized compounds because they are made from purely natural compounds and have less adverse effects. However

the single administration methods used as standard in herbal medicine

and deficient drug targeting

severely limit their anticancer activity. Single-walled carbon nanotubes (SWNTs) can be used as drug carriers. They have been modified to form Chinese anticancer medicine-SWNT compounds which can specifically target tumors

thereby significantly increasing the therapeutic effectiveness of these medicines. Water-soluble SWNTs have high stability. As a drug carrier

SWNTs functional modification of the anticancer medicine may improve the targeting and killing of tumor cells. SWNTs have been attached to the Chinese antitumor medicines paclitaxel and plumbagin and have achieved excellent therapeutic effects. Furthermore

choosing the best administration methods such as internal iliac arterial infusion

intravesical infusion and embedment of a hypodermic chemotherapeutic pump

may also improve the anticancer effects of Chinese medicine.

Abstract

Malignant cancer is the leading cause of death in man

exceeding cerebrovascular disease and heart disease. More than half of the total mortality due to malignant cancer is from lung

liver

intestinal and gastric cancer. Chemotherapy is one of the effective treatments for cancer. However

the great majority of Western anticancer medicines have considerable side effects. Herbal medicines offer many more advantages than synthesized compounds because they are made from purely natural compounds and have less adverse effects. However

the single administration methods used as standard in herbal medicine

and deficient drug targeting

severely limit their anticancer activity. Single-walled carbon nanotubes (SWNTs) can be used as drug carriers. They have been modified to form Chinese anticancer medicine-SWNT compounds which can specifically target tumors

thereby significantly increasing the therapeutic effectiveness of these medicines. Water-soluble SWNTs have high stability. As a drug carrier

SWNTs functional modification of the anticancer medicine may improve the targeting and killing of tumor cells. SWNTs have been attached to the Chinese antitumor medicines paclitaxel and plumbagin and have achieved excellent therapeutic effects. Furthermore

choosing the best administration methods such as internal iliac arterial infusion

intravesical infusion and embedment of a hypodermic chemotherapeutic pump

may also improve the anticancer effects of Chinese medicine.

关键词

Chinese Medicinesingle-walled carbon nanotube compoundChinese anticancer medicinetargeted antitumor therapy

Keywords

Chinese Medicinesingle-walled carbon nanotube compoundChinese anticancer medicinetargeted antitumor therapy

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Georg-August-Universität Göttingen, Göttingen

The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics’ Ministry of Public Health

Medical Informatics Center, Peking University

Department of Hospital Management, Peking University Health Science Center, Peking University

Neurology Department of Peking University Third Hospital, Peking University

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