Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits

Min-jian Zhang; Ya-lei Shi; Wan-jun Cheng; Zhen-wei Li; Xiang Lin

doi:10.1007/s11655-012-1088-9

Your Location：

Home >

Browse articles >

Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits

OriginalPaper | Updated：2021-08-27

- Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits
- Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits
- 中国结合医学杂志（英文版） 2014年20卷第6期页码：420-424
- Affiliations：
  
  People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Fujian Province (No. 2008J0092)
- DOI：10.1007/s11655-012-1088-9
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2012-5-19，
Scan for full text
Zhang, Mj., Shi, Yl., Cheng, Wj. et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits., Chin. J. Integr. Med. 20, 420–424 (2014). https://doi.org/10.1007/s11655-012-1088-9

Min-jian Zhang, Ya-lei Shi, Wan-jun Cheng, et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits[J]. Chinese Journal of Integrative Medicine, 2014,20(6):420-424.
Zhang, Mj., Shi, Yl., Cheng, Wj. et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits., Chin. J. Integr. Med. 20, 420–424 (2014). https://doi.org/10.1007/s11655-012-1088-9 DOI：

Min-jian Zhang, Ya-lei Shi, Wan-jun Cheng, et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits[J]. Chinese Journal of Integrative Medicine, 2014,20(6):420-424. DOI： 10.1007/s11655-012-1088-9.

摘要

To observe the relaxant effect of Aike Mixture (艾可合剂

AKM) on isolated bladder and prostatic urethral smooth muscle of rabbits. The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed in a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system. The effects of AKM in combination with methoxyamine

carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle (r=0.831

P<0.05)

reduced contractile wave amplitude (r=0.837

P<0.05) and decreased contractile frequency (r=−0.917

P<0.01). AKM significantly inhibited the increases in smooth muscle contraction induced by methoxyamine

carbachol and CaCl2. AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.

Abstract

To observe the relaxant effect of Aike Mixture (艾可合剂

carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle (r=0.831

P<0.05)

reduced contractile wave amplitude (r=0.837

P<0.05) and decreased contractile frequency (r=−0.917

P<0.01). AKM significantly inhibited the increases in smooth muscle contraction induced by methoxyamine

关键词

Aike Mixturebladder smooth muscleurethral smooth muscleα1-adrenergic receptorM-cholinergic receptorCa2+ channel

Keywords

Aike Mixturebladder smooth muscleurethral smooth muscleα1-adrenergic receptorM-cholinergic receptorCa2+ channel

references

Zhang MJ, Chu KD, Shi YL, Cheng WJ, Cheng XL, Pan XD, et al. Clinical study on treatment of chronic prostatitis/chronic pelvic pain syndrome by three different TCM principles. Chin J Integr Tradit West Med (Chin) 2007;27:989–992.

Zhang MJ, Chu KD, Cheng XL, Pan XD, Cheng WJ, Shi YL. Effect of Aike Mixture on fibroplasia and inflammatory infiltration in rats with non-bacterial prostatitis. Chin J Integr Tradit West Med (Chin) 2009;29:46–49.

Zhang MJ, Weng JF, Shi YL, Cheng WJ, Ruan XJ, Zhang QY. Effect of Aike Mixture on the inflammatory infiltration in patients with chronic prostatitis type III A. Chin J Integr Med 2011;17:26–30.

Zhang MJ, Shi YL, Cheng WJ, Li ZW, Lin X. Relaxant effect of Aike Mixture on isolated bladder and prostatic urethral smooth muscle of rabbits. J Fujian Univ Tradit Chin Med 2011;21:20–21.

Chen Q, ed. Chinese medicine pharmacological research methods. Beijing: People’s Medical Publishing House; 1994:694.

Zeng JW, Yu M, Luo YL, Zheng TZ, Qu SY, Li W, et al. Effect of rhubarb on contractile activity of isolated bladder detrusor muscle strips in guinea pigs. Pharmacol Clin Chin Mater Med (Chin) 2005;21:27–29.

Bao ZM. Prostate urine reflux and chronic prostatitis. Chin J Urol 1995;16:380.

Shen BH, Jin XD, Cai SL, Chen J, Chen GM, Zhao WP, et al. Effect and mechanism of α 1-adrenoceptor blocker combined with antibiotics for chronic prostatitis. J Clin Urol 2004;10:518–520.

Hegde SS, Choppin A, Bonhaus D, Briaud S, Loeb M, Moy TM, et al. Functional role of M2 and M3 muscarinic receptor in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 1997;120:1409–1418.

Eglen RM, Watson N. Selective muscarinic receptor agonists and antagonists. Pharmacol Toxicol 1996;78(2):59–68.

FULL TEXT LINK

More>

浏览量

830

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Effect of Aike Mixture (艾可合剂) on the inflammatory infiltration in patients with chronic prostatitis type III A

Effects of Chinese Kidney-Tonifying herbal medicine on M-cholinergic receptor and acetylcholinesterase activity in dementia mimetic mice