Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice

Ping Xu; Jun-qing Jia; En-jin Jiang; Li-ping Kang; Ke-lei Wu

doi:10.1007/s11655-012-1097-8

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Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice

OriginalPaper | Updated：2021-08-27

- Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice
- Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice
- 中国结合医学杂志（英文版） 2012年18卷第7期页码：490-495
- Affiliations：
  
  1. Department of Pharmacy, Xinxiang Medical University,Henan Province,Xinxiang,China
  2. Institute of Radiation Medicine,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1097-8
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2013-3-27，
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Xu, P., Jia, Jq., Jiang, Ej. et al. Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice., Chin. J. Integr. Med. 18, 490–495 (2012). https://doi.org/10.1007/s11655-012-1097-8

Ping Xu, Jun-qing Jia, En-jin Jiang, et al. Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice[J]. Chinese Journal of Integrative Medicine, 2012,18(7):490-495.
Xu, P., Jia, Jq., Jiang, Ej. et al. Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice., Chin. J. Integr. Med. 18, 490–495 (2012). https://doi.org/10.1007/s11655-012-1097-8 DOI：

Ping Xu, Jun-qing Jia, En-jin Jiang, et al. Protective effect of an extract of Guipi Pill (归脾丸) against radiation-induced damage in mice[J]. Chinese Journal of Integrative Medicine, 2012,18(7):490-495. DOI： 10.1007/s11655-012-1097-8.

摘要

To study the protective effect of an extract of Guipi Pill (归脾丸) against radiationinduced damage. A total of 100 Kunming mice were randomly divided into normal group

model group

positive drug group (treated with radioprotective agent “523”

5 mg/kg at 24 h before irradiation) and two treatment groups

with 20 mice in each group. The extract of water extraction-alcohol precipitation (WAP) from Guipi Pill were administered orally to the mice in the two treatment groups at the dose of 500 and 1

000 mg/kg

respectively

for 6 days prior to whole body radiation (8 Gy). Fifty mice with 10 in each group were used to observe the survival rate 30 days after radiation. The other 50 mice with 10 in each group were sacrificed on day 10 after radiation (6 Gy) in order to take blood

liver and unilateral femur. Pretreatment prior to irradiation with WAP resulted in a significantly higher 30-day survival rate of mice after exposure to a potentially lethal dose of 8-Gy radiation. WAP could significantly increase the total white blood cell count and DNA content of bone marrow

and it also increased the activity of various antioxidant enzymes

such as superoxide dismutase

catalase

total antioxidant capacity and glutathione peroxidase in liver tissue of mice

which were reduced by radiation treatment. Maleic dialdehyde level and bone marrow micronucleus rate were significantly reduced by WAP

which were increased after 6-Gy radiation. WAP of Guipi Pill could increase the 30-day survival rate and the antioxidant capacity as well as protect bone marrow in mice. WAP of Guipi Pill is an effective radioprotective agent.

Abstract

To study the protective effect of an extract of Guipi Pill (归脾丸) against radiationinduced damage. A total of 100 Kunming mice were randomly divided into normal group

model group

positive drug group (treated with radioprotective agent “523”

5 mg/kg at 24 h before irradiation) and two treatment groups

with 20 mice in each group. The extract of water extraction-alcohol precipitation (WAP) from Guipi Pill were administered orally to the mice in the two treatment groups at the dose of 500 and 1

000 mg/kg

respectively

and it also increased the activity of various antioxidant enzymes

such as superoxide dismutase

catalase

total antioxidant capacity and glutathione peroxidase in liver tissue of mice

which were reduced by radiation treatment. Maleic dialdehyde level and bone marrow micronucleus rate were significantly reduced by WAP

关键词

Chinese MedicineGuipi Pillradioprotectionbone marrowantioxidant enzymesSurvival Rate

Keywords

Chinese MedicineGuipi Pillradioprotectionbone marrowantioxidant enzymesSurvival Rate

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