A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

Ding-quan Yang; Li-ping You; Pei-hua Song; Li-xin Zhang; Yan-ping Bai

doi:10.1007/s11655-012-1173-0

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A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

OriginalPaper | Updated：2021-08-27

- A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata
- A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata
- 中国结合医学杂志（英文版） 2012年18卷第8期页码：621-625
- Affiliations：
  
  Department of Dermatology, China-Japan Friendship Hospital,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1173-0
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-8-2，
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Yang, Dq., You, Lp., Song, Ph. et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata., Chin. J. Integr. Med. 18, 621–625 (2012). https://doi.org/10.1007/s11655-012-1173-0

Ding-quan Yang, Li-ping You, Pei-hua Song, et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata[J]. Chinese Journal of Integrative Medicine, 2012,18(8):621-625.
Yang, Dq., You, Lp., Song, Ph. et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata., Chin. J. Integr. Med. 18, 621–625 (2012). https://doi.org/10.1007/s11655-012-1173-0 DOI：

Ding-quan Yang, Li-ping You, Pei-hua Song, et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata[J]. Chinese Journal of Integrative Medicine, 2012,18(8):621-625. DOI： 10.1007/s11655-012-1173-0.

摘要

To observe the efficacy and safety of total glucosides of paeony capsule (TGPC) in patients with mild and moderate alopecia areata. A total of 86 outpatients were randomly allocated into two groups of TGPC (treatment

44 cases) and compound glycyrrhizin tablet (control

42 cases). The treatment group was given oral TGPC

three times daily and 600 mg per time; the control group was given oral compound glycyrrhizin tablets

three times daily and 50 mg per time. In addition

both groups were given 10 mg of vitamin B2 and tapped the bold patches with massage. The treatment course was three months for both groups. Peripheral blood T-cell subsets (CD3+CD4+

CD3+CD8+

Th/Ts) of 10 patients randomly selected from each group respectively were tested before and after three months of treatment. The effectiveness and adverse reaction of all cases were observed each month. The safety was evaluated according to the incidence rate of adverse reaction. In the treatment group

the cured and markedly effective rate was 36.36% (16/44)

50.00% (22/44) and 68.18% (30/44) at the end of first

second and third month of treatment

respectively

and the incidence rate of adverse reaction was 13.64% (6/44). In the control group

the cured and markedly effective rate was 38.10% (16/42)

57.14% (24/42) and 71.43% (30/42)

respectively

and the incidence rate of adverse reaction was 16.67% (7/42). The cured and markedly effective rate and the incidence rate of adverse reaction were similar in both groups (P>0.05). TGPC and compound glycyrrhizin tablet can inhibit CD3+CD4+ and CD3+CD8+

and decrease the ratio of Th/Ts (P<0.05). TGPC is effective and safe in the treatment of alopecia areata.

Abstract

44 cases) and compound glycyrrhizin tablet (control

42 cases). The treatment group was given oral TGPC

three times daily and 600 mg per time; the control group was given oral compound glycyrrhizin tablets

three times daily and 50 mg per time. In addition

both groups were given 10 mg of vitamin B2 and tapped the bold patches with massage. The treatment course was three months for both groups. Peripheral blood T-cell subsets (CD3+CD4+

CD3+CD8+

the cured and markedly effective rate was 36.36% (16/44)

50.00% (22/44) and 68.18% (30/44) at the end of first

second and third month of treatment

respectively

and the incidence rate of adverse reaction was 13.64% (6/44). In the control group

the cured and markedly effective rate was 38.10% (16/42)

57.14% (24/42) and 71.43% (30/42)

respectively

and decrease the ratio of Th/Ts (P<0.05). TGPC is effective and safe in the treatment of alopecia areata.

关键词

total glucosides of paeony capsulecompound glycyrrhizin tabletsT-cell subsetsalopecia areata

Keywords

total glucosides of paeony capsulecompound glycyrrhizin tabletsT-cell subsetsalopecia areata

references

Gilhar A, Shalaginov R, Assy B, Serafimovich S, Kalish RS. Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. J Investig Dermatol Symp Proc 1999;4:207–210.

Zhou J, Yang QP, Xu F, Lou W, Sheng YY. Observation on compound glycyrrhizin in the treatment of 107 patients with alopecia areata. Chin J Dermatovenereol (Chin) 2008;2:446–447.

Zhang JX. Pharmacological action, clinical application and adverse reaction of compound glycyrrhizin tablet for alopecia areata. Guide China Med (Chin) 2011;9:198–199.

Zheng H. Pharmacological anti-rheumatic action of total glucosides of paeony. Zhejiang J Integr Tradit Chin West Med (Chin) 2008;18:520.

Ye X. Effect of total glucosides of paeony capsule combined with plum-blossom needle for alopecia areata in 50 cases. Chin J Pract Med (Chin) 2011;38:119–120.

Zhao B, ed. Clinical dermatology. 3rd ed. Nanjing: Jiangsu Science and Technology Press;2006:947–948.

Olsen EA, Hordinsky MK, Price VH, Roberts JL, Shapiro J, Canfield D, et al. Alopecia areata investigational assessment guidelines-part II. National Alopecia Areata Foundation. J Am Acad Dermatol 2004;51:440–447.

Special Committee of Dermatovenereology, Chinese Association of Integrated Traditional and Western Medicine. Standards for diagnosis and treatment of five skin diseases (Draft). Chin J Integr Tradit West Med (Chin) 1992;12:56.

McElwee KJ, Freyschmidt-Paul P, Hoffmann R, Kissling S, Hummel S, Vitacolonna M, et al. Transfer of CD8+ cells induces localized hair loss whereas CD4+/CD25− cells promote systemic alopecia areata and CD4+/CD25+ cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol 2005;124:947–957.

Gilhar A, Landau M, Assy B, Shalaginov R, Serafimovich S, Kalish RS. Mediation of alopecia areata by cooperation between CD4+ and CD8+ T lymphocytes: transfer to human scalp explants on Prkdc(scid) mice. Arch Dermatol 2002;138:916–922.

Huang WN, Hou XZ, Lu HQ, Lu HM, Xu X. Studies on the relationship between T lymphocyte subtypes and alopecia areata. Soutern China J Dermato-venereol (Chin) 2007;14:208–210.

Song FW, Bai YM, Chen YX, Cao Y, Li XJ, et al. The molecular configuration and clinical effectiveness of compound glycyrrhizin tablets (β-compound glycyrrhizin preparation). China Pharm (Chin) 2003;14:304.

Zhang ZHM. Clinical observation of compound glycyrrhizin tablets combined with cystinuria for alopecia areata. China J Leprosy Skin Dis (Chin) 2007;23:349.

Zhang MQ, Ma M. Clinical application and improvement of the total glucosides of peony. J Pediatr Pharm (Chin) 2008;12:48–50.

Wang YY, Xiong XL, Long JW. Influence of total glucosides of paeony on TNF-α and IL-8 in patients with psoriasis vulgaris stationary phase. Modern J Integr Chin Tradit West Med (Chin) 2009;18:2011–2012.

Guan XH, Wang NL. Effect of TGP on peripheral blood T cell subsets of plaque psoriasis vulgaris. Henan Tradit Chin Med (Chin) 2010;30:455–456.

Wang YW, Wang YJ. Pharmacological study and clinical application of total glucosides of peony in autoimmune diseases. J Zhejiang Univ Tradit Chin Med (Chin) 2007;31:240–241.

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