Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract

Li-li Lu; Ping Wan; Li-zhen Li; Mei-jun Zhao; Jia-yao Hu; Yong-fang Zhao

doi:10.1007/s11655-012-1177-9

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Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract

OriginalPaper | Updated：2021-08-27

- Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract
- Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract
- 中国结合医学杂志（英文版） 2013年19卷第6期页码：464-467
- Affiliations：
  
  1. Department of Biology, College of Life and Environmental Sciences, Shanghai Normal University,Shanghai,China
  2. Laboratory of Bone and Joint Pathology, State Administration of Traditional Chinese Medicine, Shanghai Shuguang Hospital,Shanghai,China
- Author bio：
- Funds：
  
  Supported by the Project of Shanghai Natural Science Foundation (No. 08JC1417000), and Research and Innovation Key Project of Shanghai Municipal Education Commission (No. 11ZZ120)
- DOI：10.1007/s11655-012-1177-9
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-3-25，
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Lu, Ll., Wan, P., Li, Lz. et al. Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract., Chin. J. Integr. Med. 19, 464–467 (2013). https://doi.org/10.1007/s11655-012-1177-9

Li-li Lu, Ping Wan, Li-zhen Li, et al. Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract[J]. Chinese Journal of Integrative Medicine, 2013,19(6):464-467.
Lu, Ll., Wan, P., Li, Lz. et al. Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract., Chin. J. Integr. Med. 19, 464–467 (2013). https://doi.org/10.1007/s11655-012-1177-9 DOI：

Li-li Lu, Ping Wan, Li-zhen Li, et al. Experimental study on topical treatment of diabetic skin ulcers with Yi Medicine “Yi Bu A Jie (以布阿节)” extract[J]. Chinese Journal of Integrative Medicine, 2013,19(6):464-467. DOI： 10.1007/s11655-012-1177-9.

摘要

To study the role and mechanism of the Yi medicine

Yi Bu A Jie (以布阿节) extract

in topical treatment of diabetic skin ulcers

with a view to finding a breakthrough natural drug for the prevention and treatment of diabetic skin ulcers. A model of diabetic skin ulcers in Kunming mice was developed. Yi Bu A Jie was extracted in a Soxhlet extractor. Two different concentrations of the extract (0.005 mg/mL and 0.01 mg/mL) were applied to the wound of diabetic skin ulcers once every 3 days

and local skin appearance and histopathological changes were observed. The shortest healing time was 25.25±2.06 day with a low concentration (P=0.0037 compared with the high concentration group

33.14±2.21 day; P=0.0082 compared with control group

28.21±2.14 days). The longest healing time was in the high concentration group (P=0.0025 compared with the control group). In both groups

a large number of inflammatory neutrophil cells were exuded during the experimental period. In the low concentration group

capillary-rich granulation tissue and actively growing fibroblasts appeared in the wound

while there was much necrotic tissue in the high concentration group. Yi Bu A Jie extract has an inhibitory effect on diabetic skin ulcers in mice

and the low concentration is more suitable.

Abstract

To study the role and mechanism of the Yi medicine

Yi Bu A Jie (以布阿节) extract

in topical treatment of diabetic skin ulcers

and local skin appearance and histopathological changes were observed. The shortest healing time was 25.25±2.06 day with a low concentration (P=0.0037 compared with the high concentration group

33.14±2.21 day; P=0.0082 compared with control group

28.21±2.14 days). The longest healing time was in the high concentration group (P=0.0025 compared with the control group). In both groups

a large number of inflammatory neutrophil cells were exuded during the experimental period. In the low concentration group

capillary-rich granulation tissue and actively growing fibroblasts appeared in the wound

while there was much necrotic tissue in the high concentration group. Yi Bu A Jie extract has an inhibitory effect on diabetic skin ulcers in mice

and the low concentration is more suitable.

关键词

Yi Bu A Jietopical therapydiabetesskin ulcers

Keywords

Yi Bu A Jietopical therapydiabetesskin ulcers

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