The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

Yu Feng; Yue-yong Xiao; Shao-dan Li; Ming-xiong Lin; Yin Zhang; Hai-ming Wang; Min Li; Xiao Zhang; Ke Cao; Yu-fei Ye; Li Zhao

doi:10.1007/s11655-012-1203-y

Your Location：

Home >

Browse articles >

The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

OriginalPaper | Updated：2021-08-27

- The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine
- The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine
- 中国结合医学杂志（英文版） 2012年18卷第9期页码：663-669
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Chinese People’s Liberation Army General Hospital,Beijing,China
  2. Department of Radiology, Chinese People’s Liberation Army General Hospital,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1203-y
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-8-31，
Scan for full text
Feng, Y., Xiao, Yy., Li, Sd. et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine., Chin. J. Integr. Med. 18, 663–669 (2012). https://doi.org/10.1007/s11655-012-1203-y

Yu Feng, Yue-yong Xiao, Shao-dan Li, et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine[J]. Chinese Journal of Integrative Medicine, 2012,18(9):663-669.
Feng, Y., Xiao, Yy., Li, Sd. et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine., Chin. J. Integr. Med. 18, 663–669 (2012). https://doi.org/10.1007/s11655-012-1203-y DOI：

Yu Feng, Yue-yong Xiao, Shao-dan Li, et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine[J]. Chinese Journal of Integrative Medicine, 2012,18(9):663-669. DOI： 10.1007/s11655-012-1203-y.

摘要

To investigate the effects of brachytherapy with computed tomography-guided percutaneous radioactive I-125 seeds interstitial implantation (ISI) synchronized chemotherapy and Chinese medicine (CM) for the treatment of advanced stage of non-small cell lung cancer (NSCLC). Ninety patients diagnosed with NSCLC by biopsy were randomly assigned to three groups: the synchronized therapy group (A)

the chemotherapy plus CM-treated group (B)

and the chemotherapy-treated group (C); a 2-month course of treatment was administered to them all. The effectiveness of treatment was evaluated based on tumor size

tumor markers (carcinoembryonic

squamous cell carcinoma-associated antigen

and cytokeratin 19 fragment)

clinical symptoms

and quality of life (QOL) in patients. The total effective rates of Groups A to C were 83.33%

46.67%

and 43.33%

respectively. The tumor markers were reduced obviously in Group A

showing signifificant difference compared with those in the other two groups. Additionally

QOL was elevated and cancer-related symptoms were alleviated more signifificant in Group A than those in Group C (all P<0.05). The synchronized therapy of I-125 implantation with chemotherapy and CM was a safe therapeutic method and can be regarded as a new mode for treatment of advanced-stage NSCLC.

Abstract

the chemotherapy plus CM-treated group (B)

and the chemotherapy-treated group (C); a 2-month course of treatment was administered to them all. The effectiveness of treatment was evaluated based on tumor size

tumor markers (carcinoembryonic

squamous cell carcinoma-associated antigen

and cytokeratin 19 fragment)

clinical symptoms

and quality of life (QOL) in patients. The total effective rates of Groups A to C were 83.33%

46.67%

and 43.33%

respectively. The tumor markers were reduced obviously in Group A

showing signifificant difference compared with those in the other two groups. Additionally

关键词

advanced non-small cell lung cancerradioactive particlebrachytherapychemotherapyChinese Medicine

Keywords

advanced non-small cell lung cancerradioactive particlebrachytherapychemotherapyChinese Medicine

references

Zou XN. Epidemiology of lung cancer in China. Chin Cancer Prevent Treat 2007;14:881–883.

Modern oncology. 2nd ed. Shanghai: Shanghai Medical University Press; 2000:877.

Berhoune M, Banu E, Scotte F, Prognon P, Oudard S, Bonan B. Therapeutic strategy for treatment of metastatic non-small cell lung cancer. Ann Pharmacother 2008;42:1640–1652.

Zheng XY. Guiding principle for clinical research on new drugs of traditional Chinese medicine. Beijing: China medicine science Press; 2002:217–218.

China Association of Chinese Medicine. Chinese guideline for the diagnosis and treatment of tumor. Beijing: China Press of Traditional Chinese Medicine; 2008:9–12.

Sun Y, Shi YK, eds. Manual of clinical oncology. Beijing: People’s Medical Publishing House; 2010:147–157.

Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European organization for research and treatment of cancer QLQ-C30: a quality of life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85:365–376.

Luo KY. The utility of interstitial implantation brachytherapy in treatment of malignant cancer. Beijing: People’s Medical Publishing House; 2008:49–77.

Cui YL, Yang G, Wang Y. The clinic value of CT-guided interstitial 125I seeds implantation for lung cancer. J Harbin Med Univ (Chin) 2008;42:400–402.

Zhang ZH. The clinic value of CT-guided interstitial 125I seeds implantation for 20 lung cancer patinets. Chin J Coal Industry Med (Chin) 2010;2:249.

Tian GY, Zhang L. CT-guided interstitial implantation of 125I seeds for non-small cell lung cancer. J Interventional Radiol (Chin) 2009;18:704–707.

Mo SX. The clinic value of CT-guided interstitial 125I seeds implantation with hyperthermia and chemotherapy for the phase III of lung cancer. Guangdong Med J (Chin) 2010;31:781–783.

Dan G, Li W, Zhao TJ, Xue P, Zhang HF, LU R. The observation of tumor markers after 125I seed implantation in the treatment of non small cell lung cancer. Med J National Defending Forces Southwest China (Chin) 2009;19:220–222.

Wang C, Wang L, Shu Q. Clinical observation of Matrine Injection combined with TP project in treatment of non small cell lung cancer. Lab Med Clin (Chin) 2010;7:1681–1682.

Wu J, Xu ZY, Wang ZQ, Zhou WD, Deng HB, Zhao XZ, et al. Clinical study on treatment of advanced non-small cell lung cancer with Kangliu Zengxiao Decoction. Chin J Integr Tradit West Med (Chin) 2010;30:137–140.

Zhang PT, Yu MW, Yang ZY, Li DR, Liu YH, Lin HS. Comparative study on the methods of Chinese medicine and Western medicine therapeutic evaluation for advanced non-small cell lung cancer. Chin J Integr Tradit West Med (Chin) 2010;30:702–705.

Shi F, Jia XB, Jia DS, Chen Y, Huang Y, Xu QM. Research of material base of Hedyotis diffusa Willd. in preventing lung cancer. China J Tradit Chin Med Pharm (Chin) 2010;25:403–408.

Wang H, Xu SF, Zhao FJ. The research progress of Scutellaria barbate D. Don on anti-cancer effect and its mechanism. J Minzu Univ China (Natural Sci, Chin) 2010;19(4):77–80.

Huang CH, Lu Y, Sun ZG, Chen L, Zhang L. Advances in studies on anti-cancer mechanism of Curcumae Rhizoma. Chin Tradit Herbal Drugs (Chin) 2010;41:1745–1747.

Chen HT, Zhu HX, Liu ZQ, Wang HB, Li Z, Yu BQ, et al. Effect of clinical observation of Danggui Buxue Decoction on tumor patients after chemotherapy. J Hebei Med Coll Continuing Education (Chin) 2008, 25(5):54–55.

Wang JH, Ren HY, Yu Y. Clinical observation of Xiaoleiwan with Erchen prescription on the sublingual gland cyst. China Modern Med (Chin) 2010;170(7):83–84.

Liu TZ, Zhang L, Wang QF, Feng FF, Nie GJ, Wu WC, et al. Diagnostic value of combined determination of serum CEA, NSE, SCC-Ag and CYFRA21-1 for lung cancer. J Zhengzhou Univ (Med Sci, Chin) 2010;45:809–811.

Wang CH, Chen MX, Zhang CZ, Tang XL, Meng Q, Zhang XQ, et al. Cancer patients quality of life scale for evaluation of Chinese version of EORTC QLQ-C30. J Practical Oncol (Chin) 2005;20:353–355.

Aronson NK, Cull A, Keasa S. The European Organization for Research and Treatment of Cancer (EORTC) modular approach to quality of life assessment in oncology. Int J Ment Health 1994;23:75–96.

Anonymous. The Elderly Lung Cancer Vinorelbine Italian Study Group. Effects of vinorelbine on quality of life and survival of elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 1999;91:66–72.

Xue D, Li PP. Clinical benefits as endpoints in advanced non-small cell lung cancer treated with integrative medicine. Chin J Integr Med 2011;17:228–231.

FULL TEXT LINK

More>

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Yiqi Zhuyu Decoction (益气逐瘀汤) Combined with FOLFOX-4 as first-line therapy in metastatic colorectal cancer

In Vitro and In Vivo inhibitory effect of the combination of Wenxia Changfu Formula (温下肠腑方) with cisplatin in non-small cell lung cancer

Effects of combined Chinese drugs and chemotherapy in treating advanced non-small cell lung cancer

Clinical observation of Shuanghuang Shengbai Granule (双黄升白颗粒) on prevention and treatment of myelosuppression caused by chemotherapy in cancer patients

Comprehensive treatment with Chinese medicine in patients with advanced non-small cell lung cancer: A multicenter, prospective, cohort study