Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial

Chien-Ying Lee; Min-Chien Yu; Chun-Che Lin; Ming-Yung Lee; James Cheng-Chung Wei; Hung-Che Shih

doi:10.1007/s11655-012-1219-3

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Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial

OriginalPaper | Updated：2021-08-27

- Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial
- Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial
- 中国结合医学杂志（英文版） 2015年21卷第8期页码：587-593
- Affiliations：
  
  1. Institute of Medicine, Chung Shan Medical University, Taichung,Taiwan,China
  2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  3. Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  4. Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  5. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  6. Department of Statistics and Informatics Science, Providence University, Taichung,Taiwan,China
  7. Graduate Institute of Integrated Medicine, China Medical University, Taichung,Taiwan,China
  8. Department of Pharmacology, Chung Shan Medical University, Taichung,Taiwan,China
- Author bio：
- Funds：
  
  James Cheng-Chung Wei and Hung-Che Shih contributed equally to this study
- DOI：10.1007/s11655-012-1219-3
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2013-2-28，
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Lee, CY., Yu, MC., Lin, CC. et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 21, 587–593 (2015). https://doi.org/10.1007/s11655-012-1219-3

Chien-Ying Lee, Min-Chien Yu, Chun-Che Lin, et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial[J]. Chinese Journal of Integrative Medicine, 2015,21(8):587-593.
Lee, CY., Yu, MC., Lin, CC. et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 21, 587–593 (2015). https://doi.org/10.1007/s11655-012-1219-3 DOI：

Chien-Ying Lee, Min-Chien Yu, Chun-Che Lin, et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial[J]. Chinese Journal of Integrative Medicine, 2015,21(8):587-593. DOI： 10.1007/s11655-012-1219-3.

摘要

Animal studies have demonstrated a lipid-modulating effect of yun-cai tea. However

little is known about the lipid-lowering effect in humans.The aim of this study was to evaluate the lipid lowering effects and safety of yun-cai tea in patients with elevated lipid levels in a human clinical trial. This was a 12-week

randomly assigned

parallel-group

double-blind

and placebo-controlled pilot clinical study. Sixty primary hyperlipidemia patients were included and randomly assigned to the yun-cai tea group (30 patients) and the placebo group (30 patients)

for 8 weeks of treatment and 4 weeks of follow-up. The primary endpoint was changes in plasma low-density lipoprotein-cholesterol (LDL-C) at 8 weeks. The secondary endpoints included total cholesterol (TC) and triglycerides (TG). Our results revealed no statistically signifificant differences in LDL-C and TC between the two groups. Despite the lack of a statistically signifificant difference in the level of TG between the two groups

a declining trend was noted. A signifificant reduction of TG was observed in the yun-cai tea group at week 8

compared to baseline (P=0.048). The incidence of stomach discomfort

gastroesophageal reflfl ux

diarrhea

and constipation was slightly higher in the yun-cai tea group. No other signifificant adverse events were found. It is unlikely that yun-cai tea used had a blood lipid reduction effect. Further larger scale clinical trials with a longer duration and larger dose are necessary.

Abstract

Animal studies have demonstrated a lipid-modulating effect of yun-cai tea. However

randomly assigned

parallel-group

double-blind

and placebo-controlled pilot clinical study. Sixty primary hyperlipidemia patients were included and randomly assigned to the yun-cai tea group (30 patients) and the placebo group (30 patients)

a declining trend was noted. A signifificant reduction of TG was observed in the yun-cai tea group at week 8

compared to baseline (P=0.048). The incidence of stomach discomfort

gastroesophageal reflfl ux

diarrhea

关键词

yun-cai tealow-density lipoprotein-cholesterolTotal Cholesteroltriglycerides

Keywords

yun-cai tealow-density lipoprotein-cholesterolTotal Cholesteroltriglycerides

references

Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, et al. Atherosclerosis: basic mechanisms, oxidation, inflammation, and genetics. Circulation 1995;91:2488–2496.

Gould AL, Davies GM, Alemao E, Yin DD, Cook JR. Cholesterol reduction yields clinical benefits: meta-analysis including recent trials. Clin Ther 2007;29:778–794.

Huang GQ, Lee CH, Lai CW, Yu MC, Hsu CH. The cholesterol-lowering effect of traditional Chinese medicine “yun-cai-tea” in hypercholesterolemia animal model. J Chin Med 2004;15:31–38.

Longvah T, Deosthale Y. Chemical and nutritional studies on Hanshi (Perilla frutescens), a traditional oilseed from Northeast India. J Am Oil Chemists’ Society 1991;68:781–784.

Simopoulos A. Omega-3 fatty acids in health and disease and in growth and development. Am J Clin Nutr 1991;54:438.

Feng LJ, Yu CH, Ying KJ, Hua J, Dai XY. Hypolipidemic and antioxidant effects of total flavonoids of Perilla Frutescens leaves in hyperlipidemia rats induced by highfat diet. Food Res Int 2011;44:404–409.

Chen J, Wu Y, Tao Z, Chen Z, Liu X. Hawthorn (shan zha) drink and its lowering effect on blood lipid levels in humans and rats. World Rev Nutr Diet 1995;77:147–154.

Zhang Z, Ho W, Huang Y, James A, Lam L, Chen Z. Hawthorn fruit is hypolipidemic in rabbits fed a high cholesterol diet. J Nutr 2002;132:5.

Choi S, Hur N, Ahn S, Kim D, Lee J, Kim D, et al. Isolation and structural determination of squalene synthase inhibitor from Prunus mume fruit. J Microbiol Biotechnol 2007;17:1970–1975.

Chen CC, Hsu JD, Wang SF, Chiang HC, Yang MY, Kao ES, et al. Hibiscus sabdariffa extract inhibits the development of atherosclerosis in cholesterol-fed rabbits. J Agric Food Chem 2003;51:5472–5477.

Lin T, Lin H, Chen C, Lin M, Chou M, Wang C. Hibiscus sabdariffa extract reduces serum cholesterol in men and women. Nutri Res 2007;27(3):140–145.

Kuriyan R, Kumar DR, Rajendran R, Kurpad AV. An evalluation of the hypolipidemic effect of an extract of Hibiscus Sabdariffa leaves in hyperlipidemic Indians: a double blind, placebo controlled trial. BMC Complement Altern Med 2010;10(27):1–8.

Xiao X, Yan D, Jin C, Zhao Y. Increasing dosage: a momentous proposition to improve therapeutic efficacy of traditional Chinese medicine. China J Chin Mater Med 2008;33:229.

Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2008;22:659–661.

Lippi G, Montagnana M, Luca Salvagno G, Targher G, Cesare Guidi G. Epidemiological association between uric acid concentration in plasma, lipoprotein(a), and the traditional lipid profile. Clin Cardiol 2010;33(2):E76–E80.

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