Syndrome pattern and its application in parallel randomized controlled trials

Byung-Cheul Shin; Sina Kim; Young-Hun Cho

doi:10.1007/s11655-012-1256-y

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Syndrome pattern and its application in parallel randomized controlled trials

OriginalPaper | Updated：2021-08-27

- Syndrome pattern and its application in parallel randomized controlled trials
- Syndrome pattern and its application in parallel randomized controlled trials
- 中国结合医学杂志（英文版） 2013年19卷第3期页码：163-171
- Affiliations：
  
  1. Division of Clinical Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea
  2. Department of Korean Medicine, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea
  3. Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan, Republic of Korea
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1256-y
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2012-12-3，
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Shin, BC., Kim, S. & Cho, YH. Syndrome pattern and its application in parallel randomized controlled trials., Chin. J. Integr. Med. 19, 163–171 (2013). https://doi.org/10.1007/s11655-012-1256-y

Byung-Cheul Shin, Sina Kim, Young-Hun Cho. Syndrome pattern and its application in parallel randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2013,19(3):163-171.
Shin, BC., Kim, S. & Cho, YH. Syndrome pattern and its application in parallel randomized controlled trials., Chin. J. Integr. Med. 19, 163–171 (2013). https://doi.org/10.1007/s11655-012-1256-y DOI：

Byung-Cheul Shin, Sina Kim, Young-Hun Cho. Syndrome pattern and its application in parallel randomized controlled trials[J]. Chinese Journal of Integrative Medicine, 2013,19(3):163-171. DOI： 10.1007/s11655-012-1256-y.

摘要

Syndrome pattern (SP) is a core concept of Chinese medicine (CM) and is used to diagnose and treat patients based on an overall analysis of symptoms and signs. This study aimed to systematically review randomized controlled trials (RCTs) using the SP concept and to demonstrate how the SP concept could be applied to the study design of parallel RCTs

considering a gold standard of clinical research. After conducting a brief systematic review by way of a PubMed search

we analyzed how the SP concept was applied to the design of RCT in a CM herbal medicine trial. We then formulated possible research questions

applied the SP concept to answer the research questions

and suggested possible RCT designs to be used for conducting future trials. Fourteen RCTs were included in our systematic review

and three key points of the SP concept were formulated for the design of parallel RCTs: the time point of SP diagnosis between before and after randomization; the relationship between the international classification of diseases (ICD) and SP for the inclusion of target population; and the proper diagnostic method of SP. In this study

we formulated three possible research questions and then suggested perspectives for five possible RCT models arrived at using SP concepts. Future trials applying SP concept to RCTs should overcome the shortcomings of past SP trials

moving CM forward from experience-based to evidence-based medicine.

Abstract

considering a gold standard of clinical research. After conducting a brief systematic review by way of a PubMed search

we analyzed how the SP concept was applied to the design of RCT in a CM herbal medicine trial. We then formulated possible research questions

applied the SP concept to answer the research questions

and suggested possible RCT designs to be used for conducting future trials. Fourteen RCTs were included in our systematic review

moving CM forward from experience-based to evidence-based medicine.

关键词

syndrome patternrandomized controlled trialTraditional Chinese Medicineevidence-based medicineIntegrative Medicine

Keywords

syndrome patternrandomized controlled trialTraditional Chinese Medicineevidence-based medicineIntegrative Medicine

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