Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia

Rui-lan Gao; Beng Hock Chong

doi:10.1007/s11655-012-1292-4

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Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia

OriginalPaper | Updated：2021-08-27

- Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia
- Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia
- 中国结合医学杂志（英文版） 2012年18卷第12期页码：897-902
- Affiliations：
  
  1. Institution of Hematology Research, The First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China
  2. Department of Hematology, St George Hospital and St George Clinical School, University of New South Wales, Kogarah,Australia
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30271597), Australia-China Institutional Links Research Program by International Development Program of Education Australia (No. IDP 2-8), Science and Technology Foundation of Zhjiang Province, China (No. 2004C23002), and Natural Science Foundation of Zhjiang Province, China (No. ZD0007)
- DOI：10.1007/s11655-012-1292-4
  中图分类号：
- 纸质出版日期：2012，
  
  网络出版日期：2012-12-13，
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Gao, Rl., Chong, B.H. Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia., Chin. J. Integr. Med. 18, 897–902 (2012). https://doi.org/10.1007/s11655-012-1292-4

Rui-lan Gao, Beng Hock Chong. Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia[J]. Chinese Journal of Integrative Medicine, 2012,18(12):897-902.
Gao, Rl., Chong, B.H. Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia., Chin. J. Integr. Med. 18, 897–902 (2012). https://doi.org/10.1007/s11655-012-1292-4 DOI：

Rui-lan Gao, Beng Hock Chong. Research and development of the effective components of panaxdiol saponin as new chinese patent medicine for treating hemocytopenia[J]. Chinese Journal of Integrative Medicine, 2012,18(12):897-902. DOI： 10.1007/s11655-012-1292-4.

摘要

Pancytopenia (hemocytopenia) such as pr imary immune primary thrombocytopenia (ITP)

aplastic anemia and chronic neutropenia (agnogenic leukocytopenia) were of ten t reated by glucocor t icoids

androgen and often treated glucocorticoids

immunosuppressive agents at present

but the response to these treatments has not been always satisfactory

and may cause serious adverse events. Our research has identified a biological active component in ginseng extract and the active component

panaxadiol saponins component (PDS-C)

was isolated from total saponins of ginsenosides

and formulated into capsules named as Painengda (派能达). We successfully obtained approval from State Food and Drug Administration (SFDA) of China in 2010 to conduct clinical trials of PDS-C as class-five new Chinese patent medicine. Phase I and phase II clinical trials of PDS-C and Painengda Capsule were carried out in the treatment of ITP and agnogenic leukocytopenia. The composition and content of PDS-C have been analyzed and defined by high-performance liquid chromatography-chromatographymass spectrometry (HPLC-MS) and HPLC using specific monomers of ginsenosides as the reference standards. mass PDS-C is very efficacious for treating mice and rats with ITP and aplastic anemia

and myelosuppression caused by chemotherapy or radiation. Our animal model studies and cell biology and molecular biology experiments demonstrated that PDS-C possessed dual activities

namely that of promoting proliferation and differentiation of hematopoietic progenitor cells

and that of regulating the immune function. PDS-C and Painengda Capsule as a new Chinese patent medicine have been successfully transferred to industry. We believe that PDS-C is effective and safe in the treatment of refractory hemocytopenia. The advantages are that it is effective in small doses

it is convenient to use because of its oral administration

its lack of adverse events

it could be used alone or in combination with pharmacological agents

which improve the efficacy and decrease adverse events.

Abstract

Pancytopenia (hemocytopenia) such as pr imary immune primary thrombocytopenia (ITP)

aplastic anemia and chronic neutropenia (agnogenic leukocytopenia) were of ten t reated by glucocor t icoids

androgen and often treated glucocorticoids

immunosuppressive agents at present

but the response to these treatments has not been always satisfactory

and may cause serious adverse events. Our research has identified a biological active component in ginseng extract and the active component

panaxadiol saponins component (PDS-C)

was isolated from total saponins of ginsenosides

and myelosuppression caused by chemotherapy or radiation. Our animal model studies and cell biology and molecular biology experiments demonstrated that PDS-C possessed dual activities

namely that of promoting proliferation and differentiation of hematopoietic progenitor cells

it is convenient to use because of its oral administration

its lack of adverse events

it could be used alone or in combination with pharmacological agents

which improve the efficacy and decrease adverse events.

关键词

panaxadiol saponinsPainengdapreclinical trialhemocytopeniaprimary immune thrombocytopeniaagnogenic leukocytopenia

Keywords

panaxadiol saponinsPainengdapreclinical trialhemocytopeniaprimary immune thrombocytopeniaagnogenic leukocytopenia

references

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Effects of panaxadiol saponins component as a new Chinese patent medicine on proliferation, differentiation and corresponding gene expression profile of megakaryocytes