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A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia
A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia
- 中国结合医学杂志（英文版） 2013年19卷第1期 页码：22-28
- Affiliations：
1. Chinese PLA Postgraduate Medical School,Beijing,China
2. Department of Chinese Medicine, the First Hospital Affiliated to Chinese PLA General Hospital,Beijing,China
3. Japan Friendship Hospital,, China,Beijing,China
4. Chinese PLA Troop,Beijing,China,61660
- Author bio：
- Funds：The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2013 Supported by the Development Fund of the First Hospital Affilicated to Chinese PLA General Hospital Research (No. ZZ2004020)
DOI：10.1007/s11655-013-1321-6
中图分类号：纸质出版日期：2013，
网络出版日期：2012-12-29，
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Li, Sn., Qian, Lq., Ma, Jl. et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia., Chin. J. Integr. Med. 19, 22–28 (2013). https://doi.org/10.1007/s11655-013-1321-6
Su-na Li, Li-qi Qian, Jian-li Ma, et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia[J]. Chinese Journal of Integrative Medicine, 2013,19(1):22-28.
Li, Sn., Qian, Lq., Ma, Jl. et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia., Chin. J. Integr. Med. 19, 22–28 (2013). https://doi.org/10.1007/s11655-013-1321-6 DOI：
Su-na Li, Li-qi Qian, Jian-li Ma, et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia[J]. Chinese Journal of Integrative Medicine, 2013,19(1):22-28. DOI： 10.1007/s11655-013-1321-6.
摘要
To observe the influence of therapy with Chinese medicine Lirukang Granule (利乳康颗粒
LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia. A total of 470 subjects were randomly assigned to three groups by the net-central randomization system
the treatment group (161 patients
treated with LRKG and psychological intervention)
the Chinese medicine group (157 patients
treated with LRKG)
and the psychological intervention group (152 patients
treated with psychological intervention). The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations
cognitive intervention and psychological persuasion
30–40 min per session
once a week. The therapy duration for all groups was three months. The efficacy was compared and anxiety state/State-Trait Anxiety Invertory (STAI) scoring was measured before and after treatment. The serum estradiol (E2)
progesterone (P)
prolactin (PRL) and follicle stimulating hormone (FSH) levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment
and a group of 20 healthy women were evaluated for comparison. A follow-up was arranged for one year after treatment. Thirty subjects were lost to follow-up. (1) Comparison of efficacy: the markedly effective rate and the total effective rate of the treatment group were 86.67% (131/150) and 98.00% (147/150)
respectively; of the Chinese medicine group
64.58% (93/144) and 90.27% (130/144)
respectively; and of the psychological intervention group
0% (0/146) and 3.42% (5/146)
respectively. The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups (P<0.05). (2) Comparison of STAI scoring: STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group (P<0.01)
but there was no significant difference compared with the psychological intervention group. (3) Comparison of levels of sex hormones: E2
P
PRL and FSH of the three patient groups were disordered before treatment
and significantly different from healthy women (P<0.01). After treatment
the levels of P and FSH of the treatment group were significantly increased (P<0.01)
E and PRL were significantly reduced
which were also significantly decreased compared with the psychological intervention groups (P<0.01). (4) Follow-up: the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment (P<0.05). (5) Adverse reactions: no obvious adverse reactions were found among the three groups. Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia. The mechanism might be related to the regulation of sex hormones.
Abstract
To observe the influence of therapy with Chinese medicine Lirukang Granule (利乳康颗粒
LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia. A total of 470 subjects were randomly assigned to three groups by the net-central randomization system
the treatment group (161 patients
treated with LRKG and psychological intervention)
the Chinese medicine group (157 patients
treated with LRKG)
and the psychological intervention group (152 patients
treated with psychological intervention). The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations
cognitive intervention and psychological persuasion
30–40 min per session
once a week. The therapy duration for all groups was three months. The efficacy was compared and anxiety state/State-Trait Anxiety Invertory (STAI) scoring was measured before and after treatment. The serum estradiol (E2)
progesterone (P)
prolactin (PRL) and follicle stimulating hormone (FSH) levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment
and a group of 20 healthy women were evaluated for comparison. A follow-up was arranged for one year after treatment. Thirty subjects were lost to follow-up. (1) Comparison of efficacy: the markedly effective rate and the total effective rate of the treatment group were 86.67% (131/150) and 98.00% (147/150)
respectively; of the Chinese medicine group
64.58% (93/144) and 90.27% (130/144)
respectively; and of the psychological intervention group
0% (0/146) and 3.42% (5/146)
respectively. The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups (P<0.05). (2) Comparison of STAI scoring: STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group (P<0.01)
but there was no significant difference compared with the psychological intervention group. (3) Comparison of levels of sex hormones: E2
P
PRL and FSH of the three patient groups were disordered before treatment
and significantly different from healthy women (P<0.01). After treatment
the levels of P and FSH of the treatment group were significantly increased (P<0.01)
E and PRL were significantly reduced
which were also significantly decreased compared with the psychological intervention groups (P<0.01). (4) Follow-up: the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment (P<0.05). (5) Adverse reactions: no obvious adverse reactions were found among the three groups. Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia. The mechanism might be related to the regulation of sex hormones.
关键词
Lirukang Granulepsychological interventioncyclomastopathymenoxeniasex hormone
Keywords
Lirukang Granulepsychological interventioncyclomastopathymenoxeniasex hormone
references
Peng CH, Liu GW. Current treatment of mammary gland proliferation. Pro Mod Biomed (Chin) 2011;11:1594–1597.
Chen ZB, Meng JP, Han YB, Zhang XY, Ai JF, Liu QM. Integrated Chinese and Western medicine treatment for 360 cases of hyperplasia of mammary gland. Chin J Surg Integr Tradit West Med (Chin) 2003:9:402–403.
Lou LH, Lou HB, Zhao H, Tang LH, Li Y, Wo XD. Study on correlativity of traditional Chinese medicine syndrome types with sexual hormones in patients of hyperplasia of mammary glands. J Tradit Chin Med (Chin) 2005:46:848–850.
Jia Y, Li L. Review on effect of traditional Chinese medicine on levels of relevant hormones in patients with hyperplasia of mammary gland. Guangming Tradit Chin Med (Chin) 2010:25:537–539.
Lu L, Li JP, Xue YZ, Zhao HW, Liang ZQ. Emotion, personality in students with menstrual disorders. Chin Ment Health J (Chin) 2005:19:156–158.
Zhang JY, Wang XY. Traditional Chinese medicine therapy for hyperplasia of mammary glands. Qingdao Med J (Chin) 2006:38:425.
Meng JF, Wang Y, Cao Y. Study on the relation of mastopathy with negative psychological factors. J Pract Med Pharm (Chin) 2006;23:1103–1105.
Freeman EW, Sammel MD, Lin H, Nelson DB. Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiatry 2006;6:375–382.
Miao AN. Analysis of changes in sex hormone levels in patients with depressive disorder before and after treatment. Jilin Med J (Chin) 2011;32:2985–2986.
Qian LQ, Pei XH, Chen RM, Xu ZY. Effect of Lirukang on the level of serum sex hormones in the model of hyperplasia of mammary glands. Chin J Inf Tradit Chin Med (Chin) 2004;11:684–686.
Qian LQ, Pei XH, Xu ZY. Experipsychological study on effect of Lirukang Liquid in rat model with hyperplasia of mammary gland. Chin J Clin Pharmacol (Chin) 2007;23:450–452.
Qian LQ, Pei XH, Xu ZY. Etiological study on hyperplasia of mammary gland—clinical analysis of 363 patients. Chin J Clin Oncol Rehabil (Chin) 1999;6:23–24.
Wang LH, ed. Diagnosis and treatment criteria for traditional Chinese medicine diseases and symptoms. Jinan: Yellow River Press;1990:195.
Ministry of Health of the People’s Republic of China. Guiding principles of clinical research on new drugs of traditional Chinese medicine. Volume 1. Beijing: China Medical Science and Techonology Press; 1993;250–255.
National standard of the People’s Republic of China—trade standards for traditional Chinese medicine. Diagnostic and efficacy criteria for traditional Chinese medicine diseases and syndromes. Nanjing: Nanjing University Press;1994;7:45–46, 60–61.
Society of Surgery, Association of Traditional Chinese Medicine. Diagnostic standard and efficacy evaluation of hyperplasia of mammary gland (revised version). China J Tradit Chin Med Pharm (Chin) 1988;3(6):66.
Wang XD, Wang XL, Ma H. Psychological heal th assessment scale manual (updated version). Beijing: Chinese Psychological Health Journal Ppress;1999:30.
Huang XJ, Xu XJ, Yu ZY, Lin JT, Liang SM, Xue P. The study of the psychological status of the patients with hyperplasia of mammary glands. Heath Psychol J (Chin) 2003;11:443–444.
Wang RX, Lian F, Sun ZG. Discuss the traditional Chinese medicine theory of the Kidney stores the essence and decides the reproduction with modern reproductive medicine. Liaoning J Tradit Chin Med (Chin) 2010;37:1672–1674.
Li R. Investigation and analysis of the risk factors relative to mammary gland hyperplasia.Chin J Modern Drug Appl (Chin) 2010;4:203.
Li J. Investigation and analysis of the risk factors of the female mammary gland hyperplasia. J Med Forum (Chin) 2010;31(6):66–67.
Luo Y, Cheng TY, Jiang JC. Detection of serum sex hormones and thyroid-stimulating hormone in menstrual disorders patients. J Clin Exp Med (Chin) 2008;7:121.
Liao RR. Influence of psychological nursing intervention on psychological state and therapeutic effectiveness of patients with cyclomastopathy. Pract Prevent Med (Chin) 2009;26:395–395.
Qian LQ, Pei XH, Xu ZY. Influence of Lirukang Liquid on general state in rat model with hyperplasia of mammary gland. J Nangjing Univ Tradit Chin Med (Nat Sci, Chin) 2002;18:167–168.
Qian LQ, Pei XH, Xu ZY. Clinical observation on treatment of hyperplasia of mammary gland by Lirukang Granule. Chin J Integr Med 2007;13:120–124.
Xu GB, Wang ZT. Therapeutic effect of Cornu Cervi for breast hyperplasia in rats. J China Pharm Univ (Chin) 2006;37:349–352.
Wang ZB, Qiu FP, Li ZM, Zhao LD. Effects of active coronet composition on macrophage phagocytosis of mice and hormone level of mastoplasia in rats. Food Sci Tech (Chin) 2007;31:225–226.
Huang XO, Qin HZ, Li B, Tan WH, Wei NQ, Deng JG, et al. Influence of Guangxi turmeric on serological markers in hepatic fibrosis in rats. Guangxi J Tradit Chin Med (Chin) 2009;32:59–61.
Feng L, Zhao WJ, Chang WZ. Research advances in pharmacological action and clinical application of Oyster. Inf Tradit Chin Med (Chin) 2011;28:114–116.
Ma HG, Guo GH, Pan RQ. Combined treatment of hyperplastic disease of the breast. J China-Japan Friendship Hosp (Chin) 2005;19:262–264.
Dong HL, Guo SX, Wang CL, Yang JS, Xiao PG. Advances in studies on chemical constituents in plants of Pseudobulbus Cremastrae seu Pleiones and their pharmacological activities. Chin Tradit Herb Drug (Chin) 2007;38:1734–1737.
Qian LQ, Pei XH, Xu ZY. Thinking and method for the treatment of hyperplasia of mammary glands with traditional Chinese medicine. J Tradit Chin Med (Chin) 2008;49:73.
Deng GX, Zhao LF, Li CX, Hao L, Liu SK, Wang WZ. Exploration on relation between psychological stress, emotion and treatment from the Liver in cyclomastopathy. Chin J Basic Med Tradit Chin Med (Chin) 2008;14:934–935.
Wu LM. Etiology and interventions of hyperplasia of mammary glands. Chin Nat Med Forn (Chin) 2011;6:48–49
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