Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin

Wei Tian; Si-yu Chen

doi:10.1007/s11655-013-1437-3

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Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin

ReviewPaper | Updated：2021-08-27

- Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin
- Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin
- 中国结合医学杂志（英文版） 2013年19卷第4期页码：315-320
- Affiliations：
  
  Department of Oncology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medcine,Shanghai,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No. 81274142, No. 30300139), Natural Science Foundation of Science and Technology Commission of Shanghai Municipality (No. 11ZR1423400), Key Project of Shanghai Municipal Education Commission (No. 07zz43)
- DOI：10.1007/s11655-013-1437-3
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-4-2，
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Tian, W., Chen, Sy. Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin., Chin. J. Integr. Med. 19, 315–320 (2013). https://doi.org/10.1007/s11655-013-1437-3

Wei Tian, Si-yu Chen. Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin[J]. Chinese Journal of Integrative Medicine, 2013,19(4):315-320.
Tian, W., Chen, Sy. Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin., Chin. J. Integr. Med. 19, 315–320 (2013). https://doi.org/10.1007/s11655-013-1437-3 DOI：

Wei Tian, Si-yu Chen. Recent advances in the molecular basis of anti-neoplastic mechanisms of oridonin[J]. Chinese Journal of Integrative Medicine, 2013,19(4):315-320. DOI： 10.1007/s11655-013-1437-3.

摘要

Oridonin

a diterpenoid isolated from Rabdosia rubescens

has been proven to possess various pharmacological and physiological effects such as anti-inflammation

anti-bacterial

and anti-neoplastic

although in recent years

more attention has been paid to its anti-neoplastic effects. For example

oridonin can trigger cell cycle arrest

apoptosis

and autophagy in different neoplastic cell lines. This review summarizes the considerable knowledge about the action mechanisms of oridonin that has been studied in recent years. The present observations reveal the novel anti-neoplastic effects of oridonin

suggesting that it may be effective as a potent alternative or adjunct drug to conventional chemotherapy.

Abstract

Oridonin

a diterpenoid isolated from Rabdosia rubescens

has been proven to possess various pharmacological and physiological effects such as anti-inflammation

anti-bacterial

and anti-neoplastic

although in recent years

more attention has been paid to its anti-neoplastic effects. For example

oridonin can trigger cell cycle arrest

apoptosis

suggesting that it may be effective as a potent alternative or adjunct drug to conventional chemotherapy.

关键词

oridoninanti-neoplasmcell cycle arrestapoptosisautophagy

Keywords

oridoninanti-neoplasmcell cycle arrestapoptosisautophagy

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