The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells

Joon-Ho Keum; Ok-Hwa Kang; Sung-Bae Kim; Su-Hyun Mun; Yun-Soo Seo; Ma-Ryong Kim; Jung-Rae Rho; Young-Seob Lee; Chung-Berm Park; Young-Guk Kim; Yong-Il Kim; sin-Hee Han; Dong-Yeul Kwon

doi:10.1007/s11655-013-1448-0

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The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells

OriginalPaper | Updated：2021-08-27

- The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells
- The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells
- 中国结合医学杂志（英文版） 2013年19卷第5期页码：380-386
- Affiliations：
  
  1. College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Jeonbuk, Republic of Korea
  2. Department of Oceanography, Kunsan National University, Kunsan, Republic of Korea
  3. National Institute of Horticultural & Herbal Science, RDA, Eumsung, Republic of Korea
- Author bio：
- Funds：
  
  Supported by the National Research Foundation of Korea Grant (No. NRF-2010-013-E00034) and the Grant of the Traditional Korean Medicine R&D project, Ministry of Health & Welfare, Republic of Korea (No. B120069)
- DOI：10.1007/s11655-013-1448-0
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-3-15，
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Keum, JH., Kang, OH., Kim, SB. et al. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells., Chin. J. Integr. Med. 19, 380–386 (2013). https://doi.org/10.1007/s11655-013-1448-0

Joon-Ho Keum, Ok-Hwa Kang, Sung-Bae Kim, et al. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells[J]. Chinese Journal of Integrative Medicine, 2013,19(5):380-386.
Keum, JH., Kang, OH., Kim, SB. et al. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells., Chin. J. Integr. Med. 19, 380–386 (2013). https://doi.org/10.1007/s11655-013-1448-0 DOI：

Joon-Ho Keum, Ok-Hwa Kang, Sung-Bae Kim, et al. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells[J]. Chinese Journal of Integrative Medicine, 2013,19(5):380-386. DOI： 10.1007/s11655-013-1448-0.

摘要

Cheongseoikki-tang (CIT

Korean)

also called Qingshu Yiqi decoction (清暑益气汤) and Seisho-ekki-to (Japanese)

is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms. In this study

the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated

focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6)

prostaglandin D2 (PGD2)

leukotriene C4 (LTC4)

and β-hexosaminidase (β-hex). Our data revealed that CITE inhibited the production of IL-6

PGD2

LTC4

and β-hex induced by PMA plus A23187 (P<0.05). These findings indicate that CITE has the potential for use in the treatment of allergy.

Abstract

Cheongseoikki-tang (CIT

Korean)

also called Qingshu Yiqi decoction (清暑益气汤) and Seisho-ekki-to (Japanese)

the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated

prostaglandin D2 (PGD2)

leukotriene C4 (LTC4)

and β-hexosaminidase (β-hex). Our data revealed that CITE inhibited the production of IL-6

PGD2

LTC4

and β-hex induced by PMA plus A23187 (P<0.05). These findings indicate that CITE has the potential for use in the treatment of allergy.

关键词

Cheongseoikki-tang ethanol extractbone marrow-derived mast cellallergyinterleukin-6prostaglandin D2leukotriene C4

Keywords

Cheongseoikki-tang ethanol extractbone marrow-derived mast cellallergyinterleukin-6prostaglandin D2leukotriene C4

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