Understanding propagated sensation along meridians by volume transmission in peripheral tissue

Wei-bo Zhang; Yan Zhao; Fuxe Kjell

doi:10.1007/s11655-013-1456-0

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Understanding propagated sensation along meridians by volume transmission in peripheral tissue

OriginalPaper | Updated：2021-08-27

- Understanding propagated sensation along meridians by volume transmission in peripheral tissue
- Understanding propagated sensation along meridians by volume transmission in peripheral tissue
- 中国结合医学杂志（英文版） 2013年19卷第5期页码：330-339
- Affiliations：
  
  1. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Science,Beijing,China
  2. School of Medicine, Xi’an Jiaotong University, Xi’an, Chian
  3. Department of Neuroscience, Karolinska Institutet, Stockholm,Sweden
- Author bio：
- Funds：
  
  Supported by National Key Basic Research Program(973 No. 2010CB530507), and National Nature Science Foundation (No. 81173206)
- DOI：10.1007/s11655-013-1456-0
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-5-15，
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Zhang, Wb., Zhao, Y. & Kjell, F. Understanding propagated sensation along meridians by volume transmission in peripheral tissue., Chin. J. Integr. Med. 19, 330–339 (2013). https://doi.org/10.1007/s11655-013-1456-0

Wei-bo Zhang, Yan Zhao, Fuxe Kjell. Understanding propagated sensation along meridians by volume transmission in peripheral tissue[J]. Chinese Journal of Integrative Medicine, 2013,19(5):330-339.
Zhang, Wb., Zhao, Y. & Kjell, F. Understanding propagated sensation along meridians by volume transmission in peripheral tissue., Chin. J. Integr. Med. 19, 330–339 (2013). https://doi.org/10.1007/s11655-013-1456-0 DOI：

Wei-bo Zhang, Yan Zhao, Fuxe Kjell. Understanding propagated sensation along meridians by volume transmission in peripheral tissue[J]. Chinese Journal of Integrative Medicine, 2013,19(5):330-339. DOI： 10.1007/s11655-013-1456-0.

摘要

Propagated sensation along meridians (PSM) is a phenomenon that a sensation moves along meridians during stimulation of an acupoint. PSM has an appearance rate of 1.3% among people and have characteristics of low speed

going toward afflicted sites and being blocked by physical pressure which is difficult to be explained by known neural and blood transmission. Volume transmission (VT) is a widespread mode of intercellular communication in the central nervous system that occurs in the extracellular fluid and in the cerebrospinal fluid. VT signals moves from source to target cells via energy gradients leading to diffusion and convection (flow) which is slow

long distance and much less space filling. VT channel diffuse forming a plexus in the extracellular space with two parameters of volume fraction and tortuosity. Some experiments showed an information transmission between adjacent and distant acupoints along meridians cross spinal segments. This process is a cross-excitation between peripheral nerve terminals which is related to nonsynaptic transmission. Some neurotransmitters or neuropeptides such as glutamate

adenosine triphosphate (ATP) and neuropeptide such as substance P

neurokinin A and calcitonin gene-related peptide relate with the cross-excitation which can be regards as VT signals. Comparing the characteristics of PSM and VT

many similar aspects can be found leading to an assumption that PSM is a process of VT in peripheral tissue along meridians. The reason why VT signals transmit along meridians is that the meridian is rich in interstitial fluid under the condition of low hydraulic resistance which has been proven experimentally. According to Darcy’s law which descript the flow of interstitial fluid and conservation equation

interstitial fluid will move toward meridians and flow along meridians that restrict the VT signals within the channel and accelerate the flow according to Fick’s diffusion law. During the process

a degranulation of histamine from mast cells happens on the route which can expand capillary and increase the blood perfusion and interstitial fluid which had already been observed. The mechanism of PSM is featured by alternative axon reflex (wired transmission

WT) and VT in peripheral tissue along meridians

sending simultaneously a continuous sensate signal to control nerve system which can be felt like a PSM.

Abstract

adenosine triphosphate (ATP) and neuropeptide such as substance P

neurokinin A and calcitonin gene-related peptide relate with the cross-excitation which can be regards as VT signals. Comparing the characteristics of PSM and VT

interstitial fluid will move toward meridians and flow along meridians that restrict the VT signals within the channel and accelerate the flow according to Fick’s diffusion law. During the process

WT) and VT in peripheral tissue along meridians

sending simultaneously a continuous sensate signal to control nerve system which can be felt like a PSM.

关键词

propagated sensation along meridiansvolume transmissionneurotransmitters and receptorsinterstitial fluid channellow hydraulic resistance

Keywords

propagated sensation along meridiansvolume transmissionneurotransmitters and receptorsinterstitial fluid channellow hydraulic resistance

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