Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine

Chun-xiao Wu; Yue Liu; Jing-chun Zhang

doi:10.1007/s11655-013-1459-x

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Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine

ReviewPaper | Updated：2021-08-27

- Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine
- Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine
- 中国结合医学杂志（英文版） 2013年19卷第5期页码：394-400
- Affiliations：
  
  Department of Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Special Research Foundation of National Clinical Research Facility of Traditional Chinese Medicine (No. JDZX2012108);China Postdoctoral Foundation (No. 200902187);Famous Doctor Inheritance Research Foundation of China Academy of Chinese Medical Sciences (CM20121018);“3+3” Famous Doctor Inheritance Program of Beijing Administration of Traditional Chinese Medicine
- DOI：10.1007/s11655-013-1459-x
  中图分类号：
- 纸质出版日期：2013，
  
  网络出版日期：2013-5-15，
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Wu, Cx., Liu, Y. & Zhang, Jc. Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine., Chin. J. Integr. Med. 19, 394–400 (2013). https://doi.org/10.1007/s11655-013-1459-x

Chun-xiao Wu, Yue Liu, Jing-chun Zhang. Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2013,19(5):394-400.
Wu, Cx., Liu, Y. & Zhang, Jc. Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine., Chin. J. Integr. Med. 19, 394–400 (2013). https://doi.org/10.1007/s11655-013-1459-x DOI：

Chun-xiao Wu, Yue Liu, Jing-chun Zhang. Chronic intermittent hypoxia and hypertension: A review of systemic inflammation and Chinese Medicine[J]. Chinese Journal of Integrative Medicine, 2013,19(5):394-400. DOI： 10.1007/s11655-013-1459-x.

摘要

Obstructive sleep apnea syndrome (OSAS) and hypertension commonly coexist. Clinical studies indicate that OSAS plays a key role in increasing the risk of prevalent hypertension. Chronic intermittent hypoxia (CIH) is the core pathological mechanism of OSAS

and has a close relationship with systemic inflammation. Growing evidence shows that CIH and hypertension are strongly related

involving markers or pathways indicative of systemic inflammation

such as high-sensitivity C-reactive protein (hs-CRP)

interleukin-6

nuclear factor-kappa B

tumor necrosis factor-α

interleukin-8 and p38 mitogen-activated protein kinase (MAPK)-dependent pathways. Oxidative stress also plays an important role in this process

including in the activation of polymorphonuclear neutrophils. However

the pathophysiological and clinical significance of systemic inflammation in CIH and hypertension is not proven. This review article highlights the relationship between CIH and hypertension through systemic inflammation and the current interventions available in Chinese medicine

to offer a background for the future treatment of OSAS-related hypertension with integrative medicine.

Abstract

and has a close relationship with systemic inflammation. Growing evidence shows that CIH and hypertension are strongly related

involving markers or pathways indicative of systemic inflammation

such as high-sensitivity C-reactive protein (hs-CRP)

interleukin-6

nuclear factor-kappa B

tumor necrosis factor-α

interleukin-8 and p38 mitogen-activated protein kinase (MAPK)-dependent pathways. Oxidative stress also plays an important role in this process

including in the activation of polymorphonuclear neutrophils. However

to offer a background for the future treatment of OSAS-related hypertension with integrative medicine.

关键词

chronic intermittent hypoxiaobstructive sleep apnea syndromehypertensionsystemic inflammationChinese Medicine

Keywords

chronic intermittent hypoxiaobstructive sleep apnea syndromehypertensionsystemic inflammationChinese Medicine

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