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Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.
Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.
- 中国结合医学杂志（英文版） 2013年19卷第10期 页码：761-770
- Affiliations：
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing,China
2. Department of Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
3. Institute of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
- Author bio：
- Funds：Supported by the International Science and Technology Cooperation Program of the People’s Republic of China (No. 2011DFA30870), and by the bilateral grant from the Ministry of Education, Youth and Sports of the Czech Republic (No. ME10116).
DOI：10.1007/s11655-013-1460-4
中图分类号：纸质出版日期：2013，
网络出版日期：2013-8-5，
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Zhu, Xx., Li, Yj., Yang, L. et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.., Chin. J. Integr. Med. 19, 761–770 (2013). https://doi.org/10.1007/s11655-013-1460-4
Xiao-xin Zhu, Yu-jie Li, Lan Yang, et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.[J]. Chinese Journal of Integrative Medicine, 2013,19(10):761-770.
Zhu, Xx., Li, Yj., Yang, L. et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.., Chin. J. Integr. Med. 19, 761–770 (2013). https://doi.org/10.1007/s11655-013-1460-4 DOI：
Xiao-xin Zhu, Yu-jie Li, Lan Yang, et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.[J]. Chinese Journal of Integrative Medicine, 2013,19(10):761-770. DOI： 10.1007/s11655-013-1460-4.
摘要
To study possible immunobiological potential of Osmunda japonica Thunb. Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×106/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent
production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. The extracts activated dose dependently
with the onset at 2.5–5 μmol/L concentrations
the high output NO production
and secretion of interferon-γ (IFN-γ)
tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3
4-hydroxybenzaldehyde. In contrasts
the acetone-type phenolics 4-hydroxybenzalacetone and 3
4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α
IL-1β
IL-6)
NO
and PGE2. The 3
4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5–10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds. Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity.
Abstract
To study possible immunobiological potential of Osmunda japonica Thunb. Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×106/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent
production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. The extracts activated dose dependently
with the onset at 2.5–5 μmol/L concentrations
the high output NO production
and secretion of interferon-γ (IFN-γ)
tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3
4-hydroxybenzaldehyde. In contrasts
the acetone-type phenolics 4-hydroxybenzalacetone and 3
4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α
IL-1β
IL-6)
NO
and PGE2. The 3
4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5–10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds. Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity.
关键词
Osmunda japonica L.extractsphenolic compoundscytokinesNitric Oxideprostaglandin E2
Keywords
Osmunda japonica L.extractsphenolic compoundscytokinesNitric Oxideprostaglandin E2
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