Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches

Jie Wang; Gui Yu

doi:10.1007/s11655-013-1461-3

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Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches

OriginalPaper | Updated：2021-08-27

- Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches
- Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches
- 中国结合医学杂志（英文版） 2014年20卷第3期页码：163-169
- Affiliations：
  
  1. Department of Cardiology, Guang’anmen Hospital,Beijing,China
  2. Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81173116)
- DOI：10.1007/s11655-013-1461-3
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2013-8-5，
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Wang, J., Yu, G. Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches., Chin. J. Integr. Med. 20, 163–169 (2014). https://doi.org/10.1007/s11655-013-1461-3

Jie Wang, Gui Yu. Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches[J]. Chinese Journal of Integrative Medicine, 2014,20(3):163-169.
Wang, J., Yu, G. Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches., Chin. J. Integr. Med. 20, 163–169 (2014). https://doi.org/10.1007/s11655-013-1461-3 DOI：

Jie Wang, Gui Yu. Biomedical mechanisms of blood stasis syndrome of coronary heart disease by systems biology approaches[J]. Chinese Journal of Integrative Medicine, 2014,20(3):163-169. DOI： 10.1007/s11655-013-1461-3.

摘要

The prevalence of coronary heart disease (CHD) is increasing

and has been a severe burden on society and family worldwide. New ideas need to be achieved for developing more efficacious and safe therapies to treat CHD. Chinese medicine (CM) uses multicomponent drugs to prevent disease and ameliorate symptoms based on patients’ different syndromes. The benefit of CM in CHD has recently been proven by increasing clinical evidence. More importantly

linking CM syndrome differentiation and biomedical diagnosis might provide innovative thinking for treating CHD. According to epidemiological investigations

blood stasis syndrome (BSS) is the major type of syndrome in CHD. Investigating the biomedical mechanisms of BSS of CHD is a topic of CM research. Because the holistic perspective of systems biology is well matched with CM

the application of omics techniques and other integrative approaches appears inherently appropriate. A wide range of omics techniques

including transcriptomics and proteomics

have been used in studies of BSS of CHD to search for a common ground of understanding. These approaches could be useful for understanding BSS of CHD from clinical and biological viewpoints. Nevertheless

current studies mainly contain results from a single approach

and they have not achieved the holistic

systematic and integrative concept of system biology. Therefore

we discuss the progress and challenges in exploring the biomedical mechanisms of BSS of CHD by systems biology approaches. With further development of systems biology

a better platform to study BSS of CHD may be provided

and biomarkers for BSS of CHD and therapeutic targets may be found. The study of BSS of CHD by systems biology approaches will also be beneficial for developing personalized treatment for BSS of CHD patients.

Abstract

The prevalence of coronary heart disease (CHD) is increasing

linking CM syndrome differentiation and biomedical diagnosis might provide innovative thinking for treating CHD. According to epidemiological investigations

the application of omics techniques and other integrative approaches appears inherently appropriate. A wide range of omics techniques

including transcriptomics and proteomics

current studies mainly contain results from a single approach

and they have not achieved the holistic

systematic and integrative concept of system biology. Therefore

we discuss the progress and challenges in exploring the biomedical mechanisms of BSS of CHD by systems biology approaches. With further development of systems biology

a better platform to study BSS of CHD may be provided

关键词

Blood Stasis Syndromecoronary heart diseasesystems biology

Keywords

Blood Stasis Syndromecoronary heart diseasesystems biology

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