Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits

Xiao-xi Tian; Bo-liang Wang; Yi-zhan Cao; Yue-xia Zhong; Yan-yang Tu; Jian-bo Xiao; Qian-feng He; Li-na Zhai

doi:10.1007/s11655-013-1513-8

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Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits

OriginalPaper | Updated：2021-08-27

- Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits
- Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits
- 中国结合医学杂志（英文版） 2015年21卷第3期页码：229-233
- Affiliations：
  
  Emergency Department, Tangdu Hospital, Fourth Military Medical University,Xi’an,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-013-1513-8
  中图分类号：
- 纸质出版日期：2015，
  
  网络出版日期：2013-10-19，
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Tian, Xx., Wang, Bl., Cao, Yz. et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits., Chin. J. Integr. Med. 21, 229–233 (2015). https://doi.org/10.1007/s11655-013-1513-8

Xiao-xi Tian, Bo-liang Wang, Yi-zhan Cao, et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits[J]. Chinese Journal of Integrative Medicine, 2015,21(3):229-233.
Tian, Xx., Wang, Bl., Cao, Yz. et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits., Chin. J. Integr. Med. 21, 229–233 (2015). https://doi.org/10.1007/s11655-013-1513-8 DOI：

Xiao-xi Tian, Bo-liang Wang, Yi-zhan Cao, et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits[J]. Chinese Journal of Integrative Medicine, 2015,21(3):229-233. DOI： 10.1007/s11655-013-1513-8.

摘要

To observe the protective effects of safflor Injection (SI) and extract of Ginkgo biloba (EGB) on lung ischemia-reperfusion injury (LIRI) and investigate its mechanism. In vivo rabbit model of LIRI was reconstructed. Forty rabbits were randomly and equally divided into four groups: sham-operation group (sham group)

ischemia-reperfusion group (model group)

ischemia-reperfusion plus SI group (safflor group) and ischemia-reperfusion plus EGB injection group (EGB group). Malondialdehyde (MDA) content

superoxide dismutase (SOD) and xanthine oxidase (XO) activity in serum were measured. The wet/dry weight ratio (W/D) of the lung tissue and activity of myeloperoxidase (MPO) were also tested. Ultrastructure change of the lung tissue was observed by the electron microscope. The expression of intercellular adhesion molecule-1 (ICAM-1) was measured by immunohistochemistry (IHC). In the model group

MDA and XO increased and SOD decreased in serum compared with the sham group (P<0.01). The values of W/D

MPO and ICAM-1 of the model group were higher than those of the sham group (P<0.01)

but those of the safflor group and EGB group were significantly lower than those of the model group (P<0.01). The IHC demonstrated that ICAM-1 expression in lung tissue of the model group was significantly higher than those of the safflor group (P<0.01). Compared with safflor group

in the EGB group MDA

MPO decreased

SOD and ICAM-1 expression increased (P<0.05)

but the change of W/D was not statistically significant (P>0.05). SI and EGB may attenuate LIRI through antioxidation

inhibition of neutrophil aggregation and down-regulation of ICAM-1 expression. But EGB had more effect on the antioxidation

while SI did better on regulating ICAM-1 expression.

Abstract

ischemia-reperfusion group (model group)

ischemia-reperfusion plus SI group (safflor group) and ischemia-reperfusion plus EGB injection group (EGB group). Malondialdehyde (MDA) content

MDA and XO increased and SOD decreased in serum compared with the sham group (P<0.01). The values of W/D

MPO and ICAM-1 of the model group were higher than those of the sham group (P<0.01)

in the EGB group MDA

MPO decreased

SOD and ICAM-1 expression increased (P<0.05)

but the change of W/D was not statistically significant (P>0.05). SI and EGB may attenuate LIRI through antioxidation

inhibition of neutrophil aggregation and down-regulation of ICAM-1 expression. But EGB had more effect on the antioxidation

while SI did better on regulating ICAM-1 expression.

关键词

Safflor InjectionGinkgo biloba extractionlungischemia-reperfusion injuryintercellular adhesion molecule-1

Keywords

Safflor InjectionGinkgo biloba extractionlungischemia-reperfusion injuryintercellular adhesion molecule-1

references

Piao YZ, Ji M. Progress of studies on myocardial ischemia inhibition effect of Carthamus tinctorius. Chin Tradit Herb Drugs (Chin) 2001;32:473–475.

Jin M, Li JR, Cai YX, Liu J, Qin LP. Antioxidative effect of aqueous components of Flower Carthamus Tinctorius L. J Card Pulmy Dis (Chin) 1998;17:277.

Liu JG, Hui G, Geng Q, Zhang BG, Wu D, Xie YC. Protective effects of Ginkgo leaf extract against extracorporeal lung ischemia-reperfusion injury. Chin J Surg Integr Tradit West Med (Chin) 2006;12:257–259.

Sekido N, Mukaida N, Harada A, Nakanishi I, Watanabe Y, Matsushima K. Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8. Nature 1993;365:654–657.

Mukaida N, Matsumoto T, Yokoi K, Harada A, Matsushima K. Inhibition of neutrophil-mediated acute inflammation injury by an antibody against interleukin-8 (IL-8). Inflamm Res 1998;47Suppl 3:S151–S157.

Han DE, Zhang XC, Tian SL, Ma LY, Yang CE, Liu CZ. Experimental study on the preventive effects of Ginkgo leaf extract agent against warm ischemic liver injury in the hepatic grafts from non heartbeating donors in pigs. Chin J Organ Trans (Chin) 2001;22:482–511.

Haines DD, Bak I, Ferdinandy P, Mahmoud FF, Al-Harbi SA, Blasig IE, et al. Cardioprotective effect of thecalcinurin inhibitor FKS06 and that PAF receptor antagonist and freeradical scavenge, Egb761, in isolate ischemic rat hearts. J Cardiovasc Pharmacol 2000;35:37–44.

Defeudis FV, Drieu K. Ginkgo biloba extract (Egb761) and CNS function: basic studies and clinical applications. Curr Drug Targets 2000;1:25–58.

Chu HY, Wang H, Wang JF, Zhang L, Ji J, Zhu XY, et al. Protective and treatment effects of Ginkgo biloba extract on ethanol-induced injury of skeletal muscles in rat. Prog Anat Sci (Chin) 2010;1:66–70.

He M, Zhang XM, Yuan HQ, Zhong X, Liu W, Hao SY, et al. Clinical study on treatment of pulmonary interstitial fibrosis with Ginkgo extract. Chin J Integ Trad West Med (Chin) 2005;3:222–224

Zhang M, Huang XY. Changes and significance of ICAM-1 and TNF-α in viral myocarditis in mice. J Tongji Univ (Med Sci, Chin) 2006;27:21–23.

Sawaya DE Jr, Zibari GB, Minardi A, Bilton B, Burney D, Granger DN, et al. P-selectin contributes to the initial recruitment of rolling and adherent leukocytes in hepatic venules after ischemia/reperfusion. Shock 1999;12:227–232.

Johns DG, Ao Z, Willette RN, Macphee CH, Douglas SA. Role of p38 MAP kinase in postcapillary venule leukocyte adhesion induced by ischemia/reperfusion injury. Pharmacol Res 2005;51:463–471.

Nakamura H, Yamamura T, Fukuta S, Matsumori A, Matsuzaki M. A pathogenic mechanism of chronic ongoing myocarditis. Jpn Circ J 1996;60:609–617.

Zhang P, Cox CJ, Alvarez KM, Cunningham MW. Cutting edge: cardiac myosin activates innate immune responses through TLRs. J Immunol 2009;183:27–31.

Altunkaya A, Oz E, Sivrikoz MC, Halit V, Yener N, Erdogan D, et al. Role of the nitric oxide pathway in ischemiareperfusion injury in isolated perfused guinea pig lungs. Mol Cell Biochem 2006;290:9–16.

Xu HY, Chen SP, Jin T, Wen XH, An XX, Xu M. Protective effects of ginaton against ischemia-reperfusion injury on the autograft after lung autotransplantation: experiment with rabbits. Natl Med J China (Chin) 2006;45:3211–3214.

Steer ML. Relationship between pancreatitis and lung diseases. Respir Physiol 2001;128:13–16.

Kan SH, Huang F, Tang J, Gao Y, Yu CL. Role of intrapulmonary expression of inducible nitric oxide synthase gene and nuclear factor kappaB activation in severe pancreatitis-associated lung injury. Inflammation 2010;33:287–294.

Weinbroum AA. Mannitol prevents acute lung injury after pancreas ischemia-reperfusion: a dose-response, ex vivo study. Lung 2009;187:215–24.

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