Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits

Qing-ping Huo; Fang Liang; Jin-pu Li; Yu-xin Wang; Han-yan Liu

doi:10.1007/s11655-013-1531-6

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Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits

OriginalPaper | Updated：2021-08-27

- Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits
- Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits
- 中国结合医学杂志（英文版） 2014年20卷第6期页码：445-449
- Affiliations：
  
  Department of Traditional Chinese Medicine, Shanghai No. 6 People’s Hospital, Affiliated to Shanghai Jiaotong University,Shanghai,China
- Author bio：
- Funds：
  
  Supported by a Research Grant from Health Bureau of Shanghai (No. 2008J003A)
- DOI：10.1007/s11655-013-1531-6
  中图分类号：
- 纸质出版日期：2014，
  
  网络出版日期：2013-11-16，
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Huo, Qp., Liang, F., Li, Jp. et al. Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits., Chin. J. Integr. Med. 20, 445–449 (2014). https://doi.org/10.1007/s11655-013-1531-6

Qing-ping Huo, Fang Liang, Jin-pu Li, et al. Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits[J]. Chinese Journal of Integrative Medicine, 2014,20(6):445-449.
Huo, Qp., Liang, F., Li, Jp. et al. Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits., Chin. J. Integr. Med. 20, 445–449 (2014). https://doi.org/10.1007/s11655-013-1531-6 DOI：

Qing-ping Huo, Fang Liang, Jin-pu Li, et al. Effects of Wenxiao Decoction (稳消方) on the expression of interleukin-6, intercellular adhesion molecular-1 and monocyte chemoattractant protein-1 in experimental atherosclerotic rabbits[J]. Chinese Journal of Integrative Medicine, 2014,20(6):445-449. DOI： 10.1007/s11655-013-1531-6.

摘要

To observe the effects of different doses of Wenxiao Decoction (稳消方) on the expression of interleukin-6 (IL-6)

intercellular adhesion molecule-1 (ICAM-1)

and monocyte chemoattractant protein-1 (MCP-1) in experimental atherosclerotic rabbits and to explore the mechanism by which it alleviates atherosclerosis. Sixty New Zealand rabbits were randomly divided into six groups: a blank group

a model group

a Simvastatin group

and high-

medium-

and low-dosage Wenxiao Decoction groups. Except for those in the blank group

all rabbits were fed with a high-cholesterol diet. Carotid atherosclerosis was established by balloon-induced carotid artery endothelium injury in conjunction with the high-cholesterol diet. After 8 weeks

all animals were euthanized to evaluate levels of IL-6 and ICAM-1 expressions (by enzyme linked immunosorbent assay) and of MCP-1 (by immunohistochemistry staining). The expressions of IL-6

ICAM-1

and MCP-1 were significantly increased in all groups except the blank group (P<0.05). However

the rabbits in the Wenxiao Decoction groups and the Simvastatin group showed significantly lower levels of IL-6

ICAM-1

and MCP-1 expression than those in the model group (P<0.05). The expressions of IL-6

ICAM-1

and MCP-1 in the highdosage Wenxiao Decoction group and the Simvastatin group were lower than those in the low-dosage Wenxiao Decoction group (P<0.05). The expression of MCP-1 in medium-dosage Wenxiao Decoction group was lower than that in the low-dosage group (P<0.05). High

medium

and low doses of Wenxiao Decoction can inhibit the expressions of IL-6

ICAM-1

and MCP-1

which may prevent and stabilize atherosclerotic plaques. There may be a direct relationship between dosage and therapeutic efficacy of Wenxiao Decoction.

Abstract

To observe the effects of different doses of Wenxiao Decoction (稳消方) on the expression of interleukin-6 (IL-6)

intercellular adhesion molecule-1 (ICAM-1)

a model group

a Simvastatin group

and high-

medium-

and low-dosage Wenxiao Decoction groups. Except for those in the blank group

all animals were euthanized to evaluate levels of IL-6 and ICAM-1 expressions (by enzyme linked immunosorbent assay) and of MCP-1 (by immunohistochemistry staining). The expressions of IL-6

ICAM-1

and MCP-1 were significantly increased in all groups except the blank group (P<0.05). However

the rabbits in the Wenxiao Decoction groups and the Simvastatin group showed significantly lower levels of IL-6

ICAM-1

and MCP-1 expression than those in the model group (P<0.05). The expressions of IL-6

ICAM-1

medium

and low doses of Wenxiao Decoction can inhibit the expressions of IL-6

ICAM-1

and MCP-1

which may prevent and stabilize atherosclerotic plaques. There may be a direct relationship between dosage and therapeutic efficacy of Wenxiao Decoction.

关键词

Wenxiao Decoctionatherosclerosisinterleukin-6intercellular adhesion molecular-1monocyte chemoattractant protein-1Chinese Medicine

Keywords

Wenxiao Decoctionatherosclerosisinterleukin-6intercellular adhesion molecular-1monocyte chemoattractant protein-1Chinese Medicine

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